The Oncosearch | Oncotarget

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Kristen Kwong, Yue Pan, Jacqueline Morales, Matthew Watson, David V. Allegakoen, Alex G. Lee, Trever G. Bivona, Peter Wipf, Christopher J. Guerriero, Jeffrey L. Brodsky, Amit J. Sabnis

Published Aug 23, 2025 · Vol. 16, No. 1 · pp. 681-696

Keywords: protein homeostasis, rhabdomyosarcoma, unfolded protein response, preclinical therapeutics, p97

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Lanlan Zhou, Leiqing Zhang, Jun Zhang, Laura Jinxuan Wu, Shengliang Zhang, Andrew George, Marina Hahn, Howard P. Safran, Clark C. Chen, Attila A. Seyhan, Eric T. Wong, Wafik S. El-Deiry

Published Mar 20, 2025 · Vol. 16, No. 1 · pp. 230-248

Keywords: glioblastoma multiforme, IDH, ONC201, ONC206, MGMT, temozolomide, radiotherapy

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death Research Paper

Chantal L. Duurland, Thijs de Gunst, Harm C. den Boer, Marion T.J. van den Bosch, Bryony J. Telford, Rogier M. Vos, Xiaolei Xie, Mingfa Zang, Fang Wang, Yingying Shao, Xiaoyu An, Jingjing Wang, Jie Cai, Ludovic Bourré, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot, Sanaz Yahyanejad

Published Jul 4, 2024 · Vol. 15, No. 1 · pp. 470-485

Keywords: miR-193a-3p, microRNA mimic, T cell mediated immunity, immunogenic cell death, cancer

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Thomas M. Cardillo, Maria B. Zalath, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Chien-Hsing Chang, David M. Goldenberg

Published Jan 30, 2024 · Vol. 15, No. 1 · pp. 144-158

Keywords: sacituzumab govitecan, Trop-2, SN-38, carboplatin, cisplatin

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 159-174

Keywords: autophagy, ER stress, GZ17-6.02, bortezomib, proteasome inhibitor

Correction: Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models Correction

An-Qi Zeng, Yan Yu, Yu-Qin Yao, Fang-Fang Yang, Mengya Liao, Lin-Jiang Song, Ya-Li Li, Yang Yu, Yu-Jue Li, Yuan-Le Deng, Shu-Ping Yang, Chen-Juan Zeng, Ping Liu, Yong-Mei Xie, Jin-Liang Yang, Yi-Wen Zhang, Ting-Hong Ye, Yu-Quan Wei

Published Oct 12, 2021 · pp. 2434-2438

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

Balraj Singh, Vanessa N. Sarli, Anthony Lucci

Published Mar 12, 2021 · Vol. 12, No. 7 · pp. 626-637

Keywords: resistant TNBC, minimal residual disease, intratumor heterogeneity, breast cancer relapse, metastasis prevention

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper

Lennox Chitsike, Chung-Hsiang Yuan, Anuradha Roy, Kristopher Boyle, Penelope J. Duerksen-Hughes

Published Feb 22, 2021 · Vol. 12, No. 6 · pp. 549-561

Keywords: HNSCC, HPV, E6, AlphaScreen™, 30-hydroxygambogic acid

miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells Research Paper

Nicholas J. Monteleone, Carol S. Lutz

Published Dec 1, 2020 · Vol. 11, No. 51 · pp. 4699-4721

Keywords: miR-708-5p, miR-708, erlotinib, paclitaxel, chemoresistance

Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer Research Paper

Thomas R. Holmes, Jenan Al-Matouq, Matti Holmes, Lauren Nicola, Justin C. Rudd, Sándor Lovas, Laura A. Hansen

Published Jul 30, 2020 · Vol. 11, No. 35 · pp. 3267-3278

Keywords: skin cancer, squamous cell carcinoma, CDC25A, 14-3-3ε, apoptosis

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Abhay Kumar Singh, Vaishali Kapoor, Dinesh Thotala, Dennis E. Hallahan

Published Jun 22, 2020 · Vol. 11, No. 27 · pp. 2647-2659

Keywords: TAF15, radiation inducible, lung cancer, antibody

Exploring the role of survivin in neuroendocrine neoplasms Research Paper

Ahmad Hanif, Sunyoung Lee, Medhavi Gupta, Ankush Chander, Eric D. Kannisto, Achamaporn Punnanitinont, Robert Fenstermaker, Michael Ciesielski, Kristopher Attwood, Jingxin Qiu, Sai Yendamuri, Renuka Iyer

Published May 26, 2020 · Vol. 11, No. 23 · pp. 2246-2258

Keywords: neuroendocrine tumors, survivin, immunohistochemistry, biomarkers, radiosensitivity

Sirolimus-eluting stents: opposite in vitro effects on the clonogenic cell potential on a long-term exposure Research Paper

Francesco Vasuri, Alessio Degiovanni, Mauro Gargiulo, William G. Thilly, Elena V. Gostjeva, Gianandrea Pasquinelli, Silvia Fittipaldi

Published Mar 30, 2020 · Vol. 11, No. 31 · pp. 2973-2981

Keywords: atherosclerosis, cell proliferation, sirolimus, stents

Randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared with etoposide phosphate, in dogs with naturally occurring lymphoma Research Paper

Pierre Boyé, Franck Floch, François Serres, Zacharie Segaoula, Juliette Hordeaux, Quentin Pascal, Virginie Coste, Sandy Courapied, Emmanuel Bouchaert, Agata Rybicka, Claire Mazuy, Laurent Marescaux, Kévyn Geeraert, Corinne Fournel-Fleury, Alain Duhamel, François Machuron, Pierre Ferré, Aurélie Pétain, Nicolas Guilbaud, Dominique Tierny, Bruno Gomes

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 671-686

Keywords: etoposide phosphate, F14512, non-Hodgkin lymphoma, pet dog model, P-glycoprotein

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Manish Charan, Piyush Dravid, Maren Cam, Bhuvana Setty, Ryan D. Roberts, Peter J. Houghton, Hakan Cam

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 510-522

Keywords: pre-metastatic niche formation, osteosarcoma, ANGPTL2, tumor microenvironment, neutrophils

Efficacy of a third-generation oncolytic herpes simplex virus in neuroendocrine tumor xenograft models Research Paper

Hideyuki Matsushima, Masaki Kaibori, Masahiko Hatta, Morihiko Ishizaki, Richi Nakatake, Tadayoshi Okumura, Kengo Yoshii, Tomoki Todo

Published Dec 24, 2019 · Vol. 10, No. 67 · pp. 7132-7141

Keywords: oncolytic virus, herpes simplex virus, neuroendocrine tumor, mouse xenograft model

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

Ali C. Ravanpay, Juliane Gust, Adam J. Johnson, Lisa S. Rolczynski, Michelle Cecchini, Cindy A. Chang, Virginia J. Hoglund, Rithun Mukherjee, Nicholas A. Vitanza, Rimas J. Orentas, Michael C. Jensen

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7080-7095

Keywords: glioblastoma, CAR T cell, EGFR, immunotherapy, mAb806

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Brian W. Simons, Vishal Kothari, Benjamin Benzon, Kamyar Ghabili, Robert Hughes, Jelani C. Zarif, Ashley E. Ross, Paula J. Hurley, Edward M. Schaeffer

Published Dec 3, 2019 · Vol. 10, No. 64 · pp. 6845-6854

Keywords: prostate cancer, bone metastasis, murine model

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Tony Yeung, Oliver Fung, Mikhail Bashkurov, Arian Khandani, Omar Subedar, Alexandra Wudwud, Patricia Shaw, Blaise Clarke, John Bartlett, Robert Rottapel, Andras Kapus

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6691-6712

Keywords: hyperploid genome, apoptosis, platinum chemotherapy, cell cycle checkpoint, ovarian cancer

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Lasse Dührsen, Sophie Hartfuß, Daniela Hirsch, Sabine Geiger, Cecile L. Maire, Jan Sedlacik, Christine Guenther, Manfred Westphal, Katrin Lamszus, Felix G. Hermann, Nils Ole Schmidt

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6049-6061

Keywords: glioblastoma, brain tumor, stem cells, gene therapy, migration

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Correction: Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models Correction

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper

miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells Research Paper

Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer Research Paper

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Exploring the role of survivin in neuroendocrine neoplasms Research Paper

Sirolimus-eluting stents: opposite in vitro effects on the clonogenic cell potential on a long-term exposure Research Paper

Randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared with etoposide phosphate, in dogs with naturally occurring lymphoma Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Efficacy of a third-generation oncolytic herpes simplex virus in neuroendocrine tumor xenograft models Research Paper

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Correction: Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models Correction

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas Research Paper

miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells Research Paper

Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer Research Paper

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Exploring the role of survivin in neuroendocrine neoplasms Research Paper

Sirolimus-eluting stents: opposite in vitro effects on the clonogenic cell potential on a long-term exposure Research Paper

Randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared with etoposide phosphate, in dogs with naturally occurring lymphoma Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Efficacy of a third-generation oncolytic herpes simplex virus in neuroendocrine tumor xenograft models Research Paper

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper