The Oncosearch | Oncotarget

Cancer prevention with rapamycin Research Perspective

Mikhail V. Blagosklonny

Published Apr 12, 2023 · Vol. 14, No. 1 · pp. 342-350

Keywords: chemoprevention, lung, rapamycin, aging, cancer

Anti-aging: senolytics or gerostatics (unconventional view) Review

Mikhail V. Blagosklonny

Published Aug 12, 2021 · Vol. 12, No. 18 · pp. 1821-1835

Keywords: geroscience, senolytics, hyperfunction theory, aging, sirolimus

Sirolimus-eluting stents: opposite in vitro effects on the clonogenic cell potential on a long-term exposure Research Paper

Francesco Vasuri, Alessio Degiovanni, Mauro Gargiulo, William G. Thilly, Elena V. Gostjeva, Gianandrea Pasquinelli, Silvia Fittipaldi

Published Mar 30, 2020 · Vol. 11, No. 31 · pp. 2973-2981

Keywords: atherosclerosis, cell proliferation, sirolimus, stents

Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells Research Paper

Sanford P.C. Hsu, John S. Kuo, Hsin-Chien Chiang, Hsin-Ell Wang, Yu-Shan Wang, Cheng-Chung Huang, Yi-Chun Huang, Mau-Shin Chi, . P. Mehta, Kwan-Hwa Chi

Published Jan 3, 2018 · Vol. 9, No. 6 · pp. 6883-6896

From rapalogs to anti-aging formula Research Perspective

Mikhail V. Blagosklonny

Published May 22, 2017 · Vol. 8, No. 22 · pp. 35492-35507

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts Research Paper

Olga V. Leontieva, Mikhail V. Blagosklonny

Published May 11, 2017 · Vol. 8, No. 65 · pp. 109848-109856

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells Research Paper

Min-Wu Chao, Han-Li Huang, Wei-Chun HuangFu, Kai-Cheng Hsu, Yi-Min Liu, Yi-Wen Wu, Chao-Feng Lin, Yi-Lin Chen, Mei-Jung Lai, Hsueh-Yun Lee, Jing-Ping Liou, Che-Ming Teng, Chia-Ron Yang

Published Feb 6, 2017 · Vol. 8, No. 17 · pp. 27772-27785

Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers Clinical Research Papers

Chi Yuen Cheung, Maggie Kam Man Ma, Wai Leung Chak, Ka Foon Chau, Sydney Chi Wai Tang

Published Jan 30, 2017 · Vol. 8, No. 27 · pp. 44833-44841

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors Clinical Research Papers

Kieuhoa T. Vo, Erin E. Karski, Nicole M. Nasholm, Shelly Allen, Fabienne Hollinger, W. Clay Gustafson, Janel R. Long-Boyle, Stephen Shiboski, Katherine K. Matthay, Steven G. DuBois

Published Oct 25, 2016 · Vol. 8, No. 14 · pp. 23851-23861

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy Clinical Research Papers

Haeseong Park, Ignacio Garrido-Laguna, Aung Naing, Siqing Fu, Gerald S. Falchook, Sarina A. Piha-Paul, Jennifer J. Wheler, David S. Hong, Apostolia M. Tsimberidou, Vivek Subbiah, Ralph G. Zinner, Ahmed O. Kaseb, Shreyaskumar Patel, Michelle A. Fanale, Vivianne M. Velez-Bravo, Funda Meric-Bernstam, Razelle Kurzrock, Filip Janku

Published Aug 31, 2016 · Vol. 7, No. 41 · pp. 67521-67531

Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantation Research Paper

Chuan Shen, Chenghong Peng, Baiyong Shen, Zhecheng Zhu, Ning Xu, Tao Li, Junjie Xie

Published Aug 25, 2016 · Vol. 7, No. 38 · pp. 62647-62656

Identification of drugs that restore primary cilium expression in cancer cells Research Paper

Niamat Ali Khan, Nicolas Willemarck, Ali Talebi, Arnaud Marchand, Maria Mercedes Binda, Jonas Dehairs, Natalia Rueda-Rincon, Veerle W. Daniels, Muralidhararao Bagadi, Deepak Balaji Thimiri Govinda Raj, Frank Vanderhoydonc, Sebastian Munck, Patrick Chaltin, Johannes V. Swinnen

Published Feb 4, 2016 · Vol. 7, No. 9 · pp. 9975-9992

The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma Research Paper

Claudia Pivonello, Mariarosaria Negri, Maria Cristina De Martino, Maria Napolitano, Cristina de Angelis, Donatella Paola Provvisiero, Gaia Cuomo, Renata Simona Auriemma, Chiara Simeoli, Francesco Izzo, Annamaria Colao, Leo J. Hofland, Rosario Pivonello

Published Jan 7, 2016 · Vol. 7, No. 9 · pp. 9718-9731

Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine Research Paper

Vivek Subbiah, Michael J. Wagner, Mary F. McGuire, Nawid M. Sarwari, Eswaran Devarajan, Valerae O. Lewis, Shanon Westin, Shumei Kato, Robert E. Brown, Pete Anderson

Published Oct 15, 2015 · Vol. 6, No. 38 · pp. 40642-40654

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression Research Paper

Mingsong Wu, Shuhui Si, Yan Li, Susan Schoen, Guang-Qian Xiao, Xueying Li, Bin Tean Teh, Guan Wu, Jindong Chen

Published Sep 21, 2015 · Vol. 6, No. 32 · pp. 32761-32773

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients Research Paper

Mau-Shin Chi, Cheng-Yen Lee, Su-Chen Huang, Kai-Lin Yang, Hui-Ling Ko, Yen-Kung Chen, Chen-Han Chung, Kuang-Wen Liao, Kwan-Hwa Chi

Published Sep 7, 2015 · Vol. 6, No. 30 · pp. 29808-29817

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Vivek Subbiah, Robert E. Brown, Mary F. McGuire, Jamie Buryanek, Filip Janku, Anas Younes, David Hong

Published Nov 19, 2013 · Vol. 5, No. 1 · pp. 95-102

Keywords: Hodgkin's lymphoma, mTOR, HDAC, Sirolimus, Vorinostat, Targeted therapy

Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD Anderson Cancer Center Phase I Population Research Paper

Jennifer Wheler, Gerald Falchook, Apostolia M. Tsimberidou, David Hong, Aung Naing, Sarina Piha-Paul, Su S. Chen, John Heymach, Siqing Fu, Su S. Chen, Bettzy Stephen, Jansina Y. Fok, Filip Janku, Razelle Kurzrock

Published Jun 4, 2013 · Vol. 4, No. 5 · pp. 772-784

Keywords: EGFR mutation, EGFR wild-type, non-small cell lung cancer, phase I trials, resistance, squamous cell

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Search Oncotarget

Cancer prevention with rapamycin Research Perspective

Anti-aging: senolytics or gerostatics (unconventional view) Review

Sirolimus-eluting stents: opposite in vitro effects on the clonogenic cell potential on a long-term exposure Research Paper

Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells Research Paper

From rapalogs to anti-aging formula Research Perspective

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts Research Paper

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells Research Paper

Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers Clinical Research Papers

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors Clinical Research Papers

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy Clinical Research Papers

Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantation Research Paper

Identification of drugs that restore primary cilium expression in cancer cells Research Paper

The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma Research Paper

Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine Research Paper

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression Research Paper

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD Anderson Cancer Center Phase I Population Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Cancer prevention with rapamycin Research Perspective

Anti-aging: senolytics or gerostatics (unconventional view) Review

Sirolimus-eluting stents: opposite in vitro effects on the clonogenic cell potential on a long-term exposure Research Paper

Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells Research Paper

From rapalogs to anti-aging formula Research Perspective

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts Research Paper

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells Research Paper

Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers Clinical Research Papers

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors Clinical Research Papers

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy Clinical Research Papers

Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantation Research Paper

Identification of drugs that restore primary cilium expression in cancer cells Research Paper

The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma Research Paper

Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine Research Paper

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression Research Paper

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD Anderson Cancer Center Phase I Population Research Paper