The Oncosearch | Oncotarget

The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells Research Paper

Michael R. Booth, Laurence Booth, Jane L. Roberts, John M. Kirkwood, Paul Dent

Published Mar 30, 2026 · Vol. 17, No. 1 · pp. 78-89

Keywords: macroautophagy, ER stress, aramchol, regorafenib, BID

Correction: Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells Correction

Steven A. Greenberg

Published Mar 20, 2026 · Vol. 17, No. 1 · pp. 57-58

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Kyle R. Cron, Ping Fang, Oanh Pham, Julie Janes, John Brandenburg, William Lu, Jonathan Zhu, Bret Peterson, Sara Tribble, Haixing Kehoe, Anastasia Makarova, Alex Iannello, Jean Chan, Justin Skoble, Hailey He, Chris Rae, Christopher D. Thanos, Akshata R. Udyavar

Published Oct 2, 2025 · Vol. 16, No. 1 · pp. 721-740

Keywords: tumor microenvironment, bacterial vector, myeloid cells, STING, IL-15

Correction: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer Correction

Valentina Belli, Vincenzo Sforza, Claudia Cardone, Erika Martinelli, Giusi Barra, Nunzia Matrone, Stefania Napolitano, Floriana Morgillo, Concetta Tuccillo, Alessandro Federico, Marcello Dallio, Carmelina Loguercio, Antonietta Gerarda Gravina, Raffaele De Palma, Fortunato Ciardiello, Teresa Troiani

Published Aug 28, 2025 · Vol. 16, No. 1 · pp. 679-679

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Kristen Kwong, Yue Pan, Jacqueline Morales, Matthew Watson, David V. Allegakoen, Alex G. Lee, Trever G. Bivona, Peter Wipf, Christopher J. Guerriero, Jeffrey L. Brodsky, Amit J. Sabnis

Published Aug 23, 2025 · Vol. 16, No. 1 · pp. 681-696

Keywords: protein homeostasis, rhabdomyosarcoma, unfolded protein response, preclinical therapeutics, p97

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

Laurence Booth, Michael R. Booth, Jane L. Roberts, Yang Yue, Emily Kinsey, Andrew Poklepovic, David Boone, L. Ashley Cowhart, Allen Baharaff, Paul Dent

Published Aug 14, 2025 · Vol. 16, No. 1 · pp. 662-678

Keywords: macroautophagy, flux, ER stress, aramchol, regorafenib

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Valeriy Domenyuk, Kasey Benson, Peggy Carter, Daniel Magee, Jian Zhang, Nitin Bhardwaj, Hongseok Tae, James Wacker, Foram Rathi, Siobhan Miick, Aastha Kohli, Joshua Carroll, Lori Cuyugan, Evelyn Perez, Wayeesha Zhang, John Collins, Patrick Kennedy, Jeremy Ellis, Adam Stark, Andrey Loskutov, Brittany Cuttone, Blake Taylor, Rebecca Feldman, Jeff Swenson, David Bryant, Robert Hahn-Lowry, Raunaq Kaushal, Jennifer R. Ribeiro, Jim Abraham, Milan Radovich, George W. Sledge, Matthew Oberley, David Spetzler

Published Aug 6, 2025 · Vol. 16, No. 1 · pp. 642-659

Keywords: companion diagnostic, molecular profiling, solid tumors, precision oncology, next-generation sequencing

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Aiden Deacon, Ava Gustafson, Allison Makovec, Ella Boytim, Gabriella von Dohlen, David Moline, Elin Kairies, Sam Kellen, Khalid Ishani, Megan L. Ludwig, Emily John, Alexis Anike, Hai Dang Nguyen, Scott M. Dehm, Justin M. Drake, Emmanuel S. Antonarakis, Justin Hwang

Published Jul 19, 2025 · Vol. 16, No. 1 · pp. 606-620

Keywords: RSPO2, prostate cancer, Wnt signaling, genomics, therapeutics

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience Research Paper

Fei Fei, Milhan Telatar, Vanina Tomasian, Lisa Chang, Olga Danilova, Javier Arias-Stella, Raju Pillai, Lorinda Soma, Parastou Tizro, Pamela S. Becker, Anthony S. Stein, Guido Marcucci, Michelle Afkhami

Published Jun 7, 2025 · Vol. 16, No. 1 · pp. 495-507

Keywords: Blastic plasmacytoid dendritic cell neoplasm (BPDCN), Next-generation sequencing (NGS), CCDC50

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights Research Paper

Cleto Dantas Nogueira, Samuel Frota, Huylmer Lucena Chaves, Juliana Cordeiro de Sousa, Guilherme de Sousa Veloso, Francisco Jonathan dos Santos Araujo, Gabriel Barbosa Silva, Samuel Silva Ferreira, Marclesson Santos Alves, Fabio Nasser, Ezequiel Rangel, Francisco Martins Neto, Iusta Caminha, Ellen Nascimento, Fabio Tavora

Published May 31, 2025 · Vol. 16, No. 1 · pp. 467-479

Keywords: HER2 mutation, NSCLC, lung cancer, targeted therapy, genomic profiling

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Reem Ali, Mashael Algethami, Amera Sheha, Shatha Alqahtani, Ahmad Altayyar, Ayat Lashen, Emad Rakha, Abdallah Alhaj Sulaiman, Srinivasan Madhusudan, Dindial Ramotar

Published May 3, 2025 · Vol. 16, No. 1 · pp. 362-378

Keywords: redox signaling, homologous recombination, protein interaction, cell cycle, protein modification

Analytical validation of a circulating tumor DNA assay using PhasED-Seq technology for detecting residual disease in B-cell malignancies Research Paper

Nina Klimova, Sandra Close, David M. Kurtz, Richard D. Hockett, Laura Hyland

Published May 2, 2025 · Vol. 16, No. 1 · pp. 329-336

Keywords: MRD, ctDNA, PhasED-Seq, CLARITY, residual disease

Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon Research Paper

Brock J. Sheehan, Bryson Edwards, Ivanna Soto Medrano, Mohammed A. El-Saidi, Wissam R. Zaidan, Asmahan A. El-Ezzi, Ruhul H. Kuddus

Published Mar 31, 2025 · Vol. 16, No. 1 · pp. 262-272

Keywords: PTGS1 and PTGS2 genes, COX-1 and COX-2 isozymes, single nucleotide polymorphism association study, prostate cancer, benign prostate hyperplasia (BPH)

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Lanlan Zhou, Leiqing Zhang, Jun Zhang, Laura Jinxuan Wu, Shengliang Zhang, Andrew George, Marina Hahn, Howard P. Safran, Clark C. Chen, Attila A. Seyhan, Eric T. Wong, Wafik S. El-Deiry

Published Mar 20, 2025 · Vol. 16, No. 1 · pp. 230-248

Keywords: glioblastoma multiforme, IDH, ONC201, ONC206, MGMT, temozolomide, radiotherapy

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, Fred Bunz

Published Feb 6, 2025 · Vol. 16, No. 1 · pp. 79-100

Keywords: p53, ionizing radiation, immortalized cells, ALDH3A1, NECTIN4

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Whitney L. Hensing, Emily L. Podany, James J. Sears, Shaili Tapiavala, Andrew A. Davis

Published Jan 9, 2025 · Vol. 16, No. 1 · pp. 11-27

Keywords: breast cancer, HER2-low, genomics

Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells Research Paper

Steven A. Greenberg

Published Jan 7, 2025 · Vol. 16, No. 1 · pp. 1-8

Keywords: immunotherapy, KLRG1

A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy Case Report

Murtaza Ahmed, Brent K. Larson, Arsen Osipov, Nilofer Azad, Andrew Hendifar

Published Oct 3, 2024 · Vol. 15, No. 1 · pp. 741-747

Keywords: pancreatic cancer, immunotherapy, metastasis

Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma Research Paper

Alexandra Jackovich, Barbara J. Gitlitz, Justin Wayne Wong Tiu-lim, Vinay Duddalwar, Kevin George King, Anthony B. El-Khoueiry, Jacob Stephen Thomas, Denice Tsao-Wei, David I. Quinn, Parkash S. Gill, Jorge J. Nieva

Published Jun 29, 2024 · Vol. 15, No. 1 · pp. 444-458

Keywords: EphrinB2, EphB4, HNSCC, pembrolizumab, HPV-negative

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

Jun Zhang, Lanlan Zhou, Shuai Zhao, Wafik S. El-Deiry

Published Jun 24, 2024 · Vol. 15, No. 1 · pp. 424-438

Keywords: TAS102, regorafenib, ERK1/2, angiogenesis, microvessel density

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The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells Research Paper

Correction: Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells Correction

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Correction: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer Correction

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience Research Paper

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights Research Paper

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Analytical validation of a circulating tumor DNA assay using PhasED-Seq technology for detecting residual disease in B-cell malignancies Research Paper

Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon Research Paper

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells Research Paper

A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy Case Report

Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma Research Paper

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells Research Paper

Correction: Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells Correction

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Correction: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer Correction

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience Research Paper

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights Research Paper

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Analytical validation of a circulating tumor DNA assay using PhasED-Seq technology for detecting residual disease in B-cell malignancies Research Paper

Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon Research Paper

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells Research Paper

A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy Case Report

Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma Research Paper

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper