The Oncosearch | Oncotarget

A personal perspective of patient-centred clinical trials Research Perspective

Trevor Tyne, Elizabeth Ivimey, Leanne Duggan, Jia Liu

Published Nov 5, 2025 · Vol. 16, No. 1 · pp. 808-812

Keywords: precision oncology, patient-centric care, clinical trials, tumor agnostic, drug development

Anti-DNA virus agent cidofovir - loaded green synthesized cerium oxide nanoparticles (Nanoceria): Nucleic acids (DNA and RNA) binding affinity and cytotoxicity effects Research Paper

Nahid Shahabadi, Saba Zendehcheshm, Fatemeh Khademi, Mohammad Mahdavi

Published Oct 23, 2025 · Vol. 16, No. 1 · pp. 768-789

Keywords: CeO₂ NPs, green synthesis, DNA interaction, RNA interaction, cytotoxicity

Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine Research Paper

Ashley C. Dodd, Nitin R. Wadhwani, Alison Lehane, Rom Brown, Kyle L. MacQuarrie, Seth D. Goldstein, Timothy B. Lautz

Published Oct 13, 2025 · Vol. 16, No. 1 · pp. 759-767

Keywords: folate receptor, fluorescent-guided surgery, pediatric tumors, pafolacianine, RNA sequencing

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Kyle R. Cron, Ping Fang, Oanh Pham, Julie Janes, John Brandenburg, William Lu, Jonathan Zhu, Bret Peterson, Sara Tribble, Haixing Kehoe, Anastasia Makarova, Alex Iannello, Jean Chan, Justin Skoble, Hailey He, Chris Rae, Christopher D. Thanos, Akshata R. Udyavar

Published Oct 2, 2025 · Vol. 16, No. 1 · pp. 721-740

Keywords: tumor microenvironment, bacterial vector, myeloid cells, STING, IL-15

Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma Research Paper

Jacob Haagsma, Yudith Ramos Valdes, Xuejin Ou, Rasheduzzaman Rashu, S.M. Mansour Haeryfar, Jim Petrik, Trevor G. Shepherd

Published Sep 16, 2025 · Vol. 16, No. 1 · pp. 697-718

Keywords: high-grade serous ovarian carcinoma, orthotopic models, inflammation, microenvironment

Correction: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer Correction

Valentina Belli, Vincenzo Sforza, Claudia Cardone, Erika Martinelli, Giusi Barra, Nunzia Matrone, Stefania Napolitano, Floriana Morgillo, Concetta Tuccillo, Alessandro Federico, Marcello Dallio, Carmelina Loguercio, Antonietta Gerarda Gravina, Raffaele De Palma, Fortunato Ciardiello, Teresa Troiani

Published Aug 28, 2025 · Vol. 16, No. 1 · pp. 679-679

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Maja Buszko, Madalyn Jones, Sruthi Chempati, Lyra Morina, Kirstin Ward, Habtom Habte, Michael Dziegielewski, Ethan M. Shevach

Published Jun 30, 2025 · Vol. 16, No. 1 · pp. 545-558

Keywords: T_reg, CD25, TME, mAb, GVHD

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Helen Qian, Heba Ali, Vivekanudeep Karri, Justin T. Low, David M. Ashley, Amy B. Heimberger, Lucy A. Godley, Adam M. Sonabend, Crismita Dmello

Published Jun 5, 2025 · Vol. 16, No. 1 · pp. 445-453

Keywords: CHEK2, immune checkpoint inhibitors, immunomodulation

Targeting PCNA/AR interaction inhibits AR-mediated signaling in castration resistant prostate cancer cells Research Paper

Shan Lu, Zhongyun Dong

Published May 8, 2025 · Vol. 16, No. 1 · pp. 383-395

Keywords: PCNA, androgen receptor, PCNA inhibitors, AR splicing variants, CRPC

METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis Research Paper

Jayasree Peroth Jayaprakash, Pragati Karemore, Piyush Khandelia

Published Apr 28, 2025 · Vol. 16, No. 1 · pp. 291-309

Keywords: oral cancer, m6A RNA methylation, METTL3, miR-146a-5p, SMAD4

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

Noor Kazim, Wang Peng, Jianbo Yue, Andrew Yen

Published Mar 14, 2025 · Vol. 16, No. 1 · pp. 202-218

Keywords: cancer biology and cell cycle regulation, retinoic acid(RA), FGR Src-family-kinase, cancer differentiation-therapy, leukemia

Correction: Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass Correction

Chih-Cheng Yang, Ladan Fazli, Salvatore Loguercio, Irina Zharkikh, Pedro Aza-Blanc, Martin E. Gleave, Dieter A. Wolf

Published Feb 12, 2025 · Vol. 16, No. 1 · pp. 65-66

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells Research Paper

Elham Taheri, Maryam Raeeszadeh-Sarmazdeh

Published Feb 6, 2025 · Vol. 16, No. 1 · pp. 118-130

Keywords: TIMP minimal variants, glioblastoma multiforme (GBM), brain cancer, MMP inhibitors

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, Fred Bunz

Published Feb 6, 2025 · Vol. 16, No. 1 · pp. 79-100

Keywords: p53, ionizing radiation, immortalized cells, ALDH3A1, NECTIN4

Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 rearranged non-small cell lung cancer: A case report Case Report

Jenny L. Wu, Wade T. Iams

Published Jan 16, 2025 · Vol. 16, No. 1 · pp. 39-42

Keywords: ROS1 rearrangement, RET rearrangement, non-small cell lung cancer, targeted therapy, case report

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Whitney L. Hensing, Emily L. Podany, James J. Sears, Shaili Tapiavala, Andrew A. Davis

Published Jan 9, 2025 · Vol. 16, No. 1 · pp. 11-27

Keywords: breast cancer, HER2-low, genomics

Persistence barcodes: A novel approach to reducing bias in radiological analysis Editorial

Yashbir Singh, Colleen Farrelly, Quincy A. Hathaway, Gunnar Carlsson

Published Nov 4, 2024 · Vol. 15, No. 1 · pp. 784-786

Keywords: persistence barcodes, radiology, image features

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, Peter M. Glazer

Published Sep 20, 2024 · Vol. 15, No. 1 · pp. 699-713

Keywords: 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51

UBA1 dysfunction in VEXAS and cancer Research Perspective

Maki Sakuma, Torsten Haferlach, Wencke Walter

Published Aug 27, 2024 · Vol. 15, No. 1 · pp. 644-658

Keywords: VEXAS, MDS, clonal cytopenia, ubiquitin, inflammation

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Zhen Li, Mohammed A. Alshagawi, Rebecca A. Oot, Mariam K. Alamoudi, Kevin Su, Wenhui Li, Michael P. Collins, Stephan Wilkens, Michael Forgac

Published Aug 5, 2024 · Vol. 15, No. 1 · pp. 575-587

Keywords: vacuolar ATPase, breast cancer, invasion, tumor metastasis, tumor growth

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European Cancer and Oncology Congress

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Search Oncotarget

A personal perspective of patient-centred clinical trials Research Perspective

Anti-DNA virus agent cidofovir - loaded green synthesized cerium oxide nanoparticles (Nanoceria): Nucleic acids (DNA and RNA) binding affinity and cytotoxicity effects Research Paper

Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine Research Paper

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma Research Paper

Correction: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer Correction

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Targeting PCNA/AR interaction inhibits AR-mediated signaling in castration resistant prostate cancer cells Research Paper

METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis Research Paper

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

Correction: Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass Correction

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells Research Paper

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 rearranged non-small cell lung cancer: A case report Case Report

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Persistence barcodes: A novel approach to reducing bias in radiological analysis Editorial

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

UBA1 dysfunction in VEXAS and cancer Research Perspective

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A personal perspective of patient-centred clinical trials Research Perspective

Anti-DNA virus agent cidofovir - loaded green synthesized cerium oxide nanoparticles (Nanoceria): Nucleic acids (DNA and RNA) binding affinity and cytotoxicity effects Research Paper

Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine Research Paper

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma Research Paper

Correction: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer Correction

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Targeting PCNA/AR interaction inhibits AR-mediated signaling in castration resistant prostate cancer cells Research Paper

METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis Research Paper

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

Correction: Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass Correction

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells Research Paper

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 rearranged non-small cell lung cancer: A case report Case Report

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Persistence barcodes: A novel approach to reducing bias in radiological analysis Editorial

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

UBA1 dysfunction in VEXAS and cancer Research Perspective

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper