The Oncosearch | Oncotarget

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Kyle R. Cron, Ping Fang, Oanh Pham, Julie Janes, John Brandenburg, William Lu, Jonathan Zhu, Bret Peterson, Sara Tribble, Haixing Kehoe, Anastasia Makarova, Alex Iannello, Jean Chan, Justin Skoble, Hailey He, Chris Rae, Christopher D. Thanos, Akshata R. Udyavar

Published Oct 2, 2025 · Vol. 16, No. 1 · pp. 721-740

Keywords: tumor microenvironment, bacterial vector, myeloid cells, STING, IL-15

Neutrophil PAD4: how does it function in cancer beyond promoting NETosis? Editorial

Laura Garcia-Gerique, Yulia Nefedova

Published Feb 16, 2023 · Vol. 14, No. 1 · pp. 258-260

Keywords: PAD4, PMN-MDSC, neutrophils, neutrophil migration

The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies Research Paper

Jyothi Puvula, Narendra Maddu, Nagajothi Gutam, Asha Parimal, Pongali B. Raghavendra

Published Dec 1, 2022 · Vol. 13, No. 1 · pp. 1323-1340

Keywords: allethrin, prallethrin, autophagy, apoptosis, Ccl2

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Raquel Torres-Guzmán, Maria Patricia Ganado, Cecilia Mur, Carlos Marugan, Carmen Baquero, Yanzhu Yang, Yi Zeng, Huimin Bian, Jian Du, Alfonso de Dios, Oscar Puig, María José Lallena

Published Jun 22, 2022 · Vol. 13, No. 1 · pp. 864-875

Keywords: abemaciclib, breast cancer, cell lines, CDK4/6, continuous dosing

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses Research Paper

Diana P. Saraiva, Bruna F. Correia, Rute Salvador, Nídia de Sousa, António Jacinto, Sofia Braga, M. Guadalupe Cabral

Published Nov 15, 2021 · Vol. 12, No. 24 · pp. 2388-2403

Keywords: breast cancer, chemotherapy response, tumor-associated neutrophils, low density neutrophils, biomarker

Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas Research Paper

Robert Hsu, Yasmine Baca, Joanne Xiu, Rongfu Wang, J. Nicholas Bodor, Chul Kim, Hina Khan, Hirva Mamdani, Misako Nagasaka, Sonam Puri, Stephen V. Liu, W. Michael Korn, Jorge J. Nieva

Published Nov 13, 2021 · Vol. 12, No. 25 · pp. 2449-2458

Keywords: lung cancer, tumor microenvironment, diagnostic biomarkers, biomarkers for immunotherapy, cancer testis antigen

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy Review

Ana Chor, Maria Adriana Skeff, Christina Takiya, Raquel Gonçalves, Marcos Dias, Marcos Farina, Leonardo R. Andrade, Valeria de Mello Coelho

Published Oct 1, 2021 · Vol. 12, No. 22 · pp. 2283-2299

Keywords: oral mucositis, inflammation, regeneration, polymers, tissue engineering

A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection Research Paper

Shay Sharon, Jason R. Baird, Shelly Bambina, Gwen Kramer, Tiffany C. Blair, Shawn M. Jensen, Rom S. Leidner, R. Bryan Bell, Nardy Casap, Marka R. Crittenden, Michael J. Gough

Published May 29, 2021 · Vol. 12, No. 13 · pp. 1201-1213

Keywords: head and neck cancer, T-cell, immunotherapy, biomaterial, intratumoral

Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma Research Paper

Barbara Marengo, Elda Meta, Chiara Brullo, Chiara De Ciucis, Renata Colla, Andrea Speciale, Ombretta Garbarino, Olga Bruno, Cinzia Domenicotti

Published Aug 27, 2020 · Vol. 11, No. 37 · pp. 3459-3472

Keywords: tumor angiogenesis, neuroblastoma, vascular mimicry, pyrazolyl-urea derivatives, dihydro-imidazo-pyrazolyl-urea derivatives

Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy Research Paper

Wojciech Dawicki, Kevin J.H. Allen, Ravendra Garg, Eileen M. Geoghegan, Mark S. Berger, Dale L. Ludwig, Ekaterina Dadachova

Published Aug 26, 2020 · Vol. 11, No. 39 · pp. 3571-3581

Keywords: anti-CD45 targeted lymphodepletion, radioimmunotherapy, adoptive cell therapy, 131Iodine, 177Lutetium

Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats Research Paper

Giseli Mitsuy Kayahara, Vitor Bonetti Valente, Rosani Belzunces Pereira, Felipe Yudi Kabeya Lopes, Marcelo Macedo Crivelini, Glauco Issamu Miyahara, Éder Ricardo Biasoli, Sandra Helena Penha Oliveira, Daniel Galera Bernabé

Published Mar 28, 2020 · Vol. 11, No. 20 · pp. 1816-1831

Keywords: melatonin, cancer, oral cancer, carcinogenesis, pineal gland

Empty SV40 capsids increase survival of septic rats by eliciting numerous host signaling networks that participate in a number of systemic functions Research Paper

Orly Ben-Nun-Shaul, Rohit Srivastava, Sharona Elgavish, Shashi Gandhi, Yuval Nevo, Hadar Benyamini, Arieh Eden, Ariella Oppenheim

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 574-588

Keywords: sepsis, empty SV40 capsids, RNAseq, signaling, cellular functions

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Manish Charan, Piyush Dravid, Maren Cam, Bhuvana Setty, Ryan D. Roberts, Peter J. Houghton, Hakan Cam

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 510-522

Keywords: pre-metastatic niche formation, osteosarcoma, ANGPTL2, tumor microenvironment, neutrophils

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

Brandi L. Carofino, Kayla M. Dinshaw, Pui Yan Ho, Christophe Cataisson, Aleksandra M. Michalowski, Andrew Ryscavage, Addie Alkhas, Nathan W. Wong, Vishal Koparde, Stuart H. Yuspa

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7251-7275

Keywords: in situ hybridization, single-cell RNA-sequencing, stroma, miRNA, immune infiltration

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Sergey V. Novitskiy, Rinat Zaynagetdinov, Georgii Vasiukov, Sergey Gutor, Wei Han, Ana Serezani, Anton Matafonov, Linda A. Gleaves, Taylor P. Sherrill, Vasiliy V. Polosukhin, Timothy S. Blackwell

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7031-7042

Keywords: lung cancer, NF-κB, Mer-TK, macrophage, Kras

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers Research Paper

Yosuke Osawa, Ekumi Kojika, Koji Nishikawa, Masamichi Kimura, Shigenori Osakaya, Hiromi Miyauchi, Tatsuya Kanto, Yutaka Kawakami, Kiminori Kimura

Published Apr 30, 2019 · Vol. 10, No. 32 · pp. 3013-3026

Keywords: PD-L1, β-catenin, CBP, colon cancer, metastatic liver cancer

Neglected players: Tumor associated neutrophils involvement in chronic lymphocytic leukemia progression Editorial

Enrique Podaza, Denise Risnik

Published Feb 17, 2019 · Vol. 10, No. 20 · pp. 1862-1863

Neutrophil extracellular traps promote peritoneal metastasis of colon cancer cells Research Paper

Amr A. Al-Haidari, Nader Algethami, Mattias Lepsenyi, Milladur Rahman, Ingvar Syk, Henrik Thorlacius

Published Feb 8, 2019 · Vol. 10, No. 12 · pp. 1238-1249

Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma Research Paper

Nicholas M. Szigetvari, Deepika Dhawan, JosÃ© A. Ramos-Vara, Christopher P. Leamon, Patrick J. Klein, A. Audrey Ruple, Hock Gan Heng, Michael R. Pugh, Satish Rao, Iontcho R. Vlahov, Pierre L. Deshuillers, Philip S. Low, Lindsey M. Fourez, Ashleigh M. Cournoyer, Deborah W. Knapp

Published Dec 11, 2018 · Vol. 9, No. 97 · pp. 37042-37053

Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression Research Paper

Marie Simonneau, Eric Frouin, Vincent Huguier, Cynthia Jermidi, Jean FranÃ§ois JÃ©gou, Julie Godet, Anne Barra, Isabelle Paris, Pierre Levillain, Sevda Cordier-Dirikoc, Nathalie Pedretti, FranÃ§ois Xavier Bernard, Jean Claude Lecron, Franck Morel, Laure Favot

Published Nov 23, 2018 · Vol. 9, No. 92 · pp. 36457-36473

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ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Neutrophil PAD4: how does it function in cancer beyond promoting NETosis? Editorial

The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies Research Paper

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses Research Paper

Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas Research Paper

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy Review

A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection Research Paper

Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma Research Paper

Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy Research Paper

Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats Research Paper

Empty SV40 capsids increase survival of septic rats by eliciting numerous host signaling networks that participate in a number of systemic functions Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers Research Paper

Neglected players: Tumor associated neutrophils involvement in chronic lymphocytic leukemia progression Editorial

Neutrophil extracellular traps promote peritoneal metastasis of colon cancer cells Research Paper

Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma Research Paper

Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Neutrophil PAD4: how does it function in cancer beyond promoting NETosis? Editorial

The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies Research Paper

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses Research Paper

Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas Research Paper

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy Review

A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection Research Paper

Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma Research Paper

Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy Research Paper

Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats Research Paper

Empty SV40 capsids increase survival of septic rats by eliciting numerous host signaling networks that participate in a number of systemic functions Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers Research Paper

Neglected players: Tumor associated neutrophils involvement in chronic lymphocytic leukemia progression Editorial

Neutrophil extracellular traps promote peritoneal metastasis of colon cancer cells Research Paper

Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma Research Paper

Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression Research Paper