Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

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Rapamycin Press LLC dba Impact Journals is the publisher of Oncotarget: www.impactjournals.com.

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Correction: S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting MicroRNA 34a/b-methionine adenosyltransferase 2A/2B axis Correction

Maria Lauda Tomasi, Carla Cossu, Ylenia Spissu, Andrea Floris, Minjung Ryoo, Ainhoa Iglesias-Ara, Qiang Wang, Stephen J. Pandol, Neil A. Bhowmick, Ekihiro Seki, Edwin M. Posadas, Shelly C. Lu

Published Apr 24, 2026 · Vol. 17, No. 1 · pp. 207-208

Essential amino acids as diagnostic biomarkers of hepatocellular carcinoma based on metabolic analysis Research Paper

Yuji Morine, Tohru Utsunomiya, Hisami Yamanaka-Okumura, Yu Saito, Shinichiro Yamada, Tetsuya Ikemoto, Satoru Imura, Shohei Kinoshita, Akiyoshi Hirayama, Yasuhito Tanaka, Mitsuo Shimada

Published Oct 27, 2022 · Vol. 13, No. 1 · pp. 1286-1298

Keywords: metabolomics, essential amino acid, hepatocellular carcinoma, diagnostic biomarker

Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer Research Paper

Kanako Sendo, Manabu Seino, Tsuyoshi Ohta, Satoru Nagase

Published Jan 24, 2022 · Vol. 13, No. 1 · pp. 224-236

Keywords: endometrial cancer, glutathione, sulfasalazine, xCT, cystathionine gamma-lyase

Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors Research Paper

Karamat Mohammad, Vladimir I. Titorenko

Published Mar 19, 2021 · Vol. 12, No. 7 · pp. 608-625

Keywords: cellular aging, geroprotectors, caloric restriction, metabolism, methionine

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

Francesca R. Dejure, Joachim Butzer, Ralph K. Lindemann, Balca R. Mardin

Published Sep 18, 2020 · Vol. 11, No. 48 · pp. 4490-4503

Keywords: SLC6A14, metabolic stress, transcriptional regulation, methionine, AMPK

Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study Research Paper

Jéssica Reis Santos, Dan Linetzky Waitzberg, Ismael Dale Cotrim Guerreiro da Silva, Tharcisio Citrangulo Tortelli Junior, Luciana Rodrigues Carvalho Barros, Gisele André Baptista Canuto, Andréa Tedesco Faccio, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Marina Franco Maggi Tavares, Ana Cristina Martinez, Ângela Flavia Logullo, Raquel Suzana M.M. Torrinhas, Graziela Ravacci

Published Apr 18, 2020 · Vol. 11, No. 18 · pp. 1637-1652

Keywords: invasive ductal carcinoma, targeted metabolomics, untargeted metabolomics, tumor metabolism, one-carbon metabolism

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Apr 19, 2019 · Vol. 10, No. 29 · pp. 2835-2854

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Mar 29, 2019

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Mar 29, 2019

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Mar 29, 2019

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Mar 29, 2019

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Mar 29, 2019

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Mar 28, 2019

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes Research Paper

Maria M. Simile, Graziella Peitta, Maria L. Tomasi, Stefania Brozzetti, Claudio F. Feo, Alberto Porcu, Antonio Cigliano, Diego F. Calvisi, Francesco Feo, Rosa M. Pascale

Published Mar 28, 2019

Keywords: methionine metabolism, methyladenosyltransferases, S-adenosylmethionine, HCC prognosis, HCC therapy

Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes Research Paper

Tina Huang, Roxanna Garcia, Jin Qi, Rishi Lulla, Craig Horbinski, Amir Behdad, Nitin Wadhwani, Ali Shilatifard, Charles James, Amanda M. Saratsis

Published Dec 14, 2018 · Vol. 9, No. 98 · pp. 37112-37124

Biochemical and cellular consequences of the antithrombin p.Met1? mutation identified in a severe thrombophilic family Research Paper

JosÃ© Navarro-FernÃ¡ndez, MarÃa Eugenia de la Morena-Barrio, Emma MartÃnez-Alonso, Ingunn Dybedal, Mara Toderici, Nataliya Bohdan, Antonia MiÃ±ano, Ketil Heimdal, Ulrich Abildgaard, JosÃ© Ãngel MartÃnez-MenÃ¡rguez, Javier Corral, Vicente Vicente

Published Sep 4, 2018 · Vol. 9, No. 69 · pp. 33202-33214

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs Research Paper

Ewelina WÄ™glarz-Tomczak, MichaÅ‚ Talma, MirosÅ‚aw Giurg, Hans V. Westerhoff, Robert Janowski, Artur Mucha

Published Jun 29, 2018 · Vol. 9, No. 50 · pp. 29365-29378

Meta-analysis of homocysteine-related factors on the risk of colorectal cancer Meta-Analysis

S. Pamela K. Shiao, Amanda Lie, Chong Ho Yu

Published May 22, 2018 · Vol. 9, No. 39 · pp. 25681-25697

Computational modeling of methionine cycle-based metabolism and DNA methylation and the implications for anti-cancer drug response prediction Research Paper

Mengying Zhang, Christian Saad, Lien Le, Kathrin Halfter, Bernhard Bauer, Ulrich R. Mansmann, Jian Li

Published Apr 27, 2018 · Vol. 9, No. 32 · pp. 22546-22558

Improvement of non-alcoholic steatohepatitis by hepatocyte-like cells generated from iPSCs with Oct4/Sox2/Klf4/Parp1 Research Paper

Yueh Chien, Chi-Shuan Huang, Hsin-Chi Lin, Kai-Hsi Lu, Ping-Hsing Tsai, Ying-Hsiu Lai, Kuan-Hsuan Chen, Shou-Dong Lee, Yi-Hsiang Huang, Chien-Ying Wang

Published Apr 6, 2018 · Vol. 9, No. 26 · pp. 18594-18606