The Oncosearch | Oncotarget

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

Laurence Booth, Michael R. Booth, Jane L. Roberts, Yang Yue, Emily Kinsey, Andrew Poklepovic, David Boone, L. Ashley Cowhart, Allen Baharaff, Paul Dent

Published Aug 14, 2025 · Vol. 16, No. 1 · pp. 662-678

Keywords: macroautophagy, flux, ER stress, aramchol, regorafenib

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Yan Luo, Lei Liu, Yang Wu, Karnika Singh, Bing Su, Nan Zhang, Xiaowei Liu, Yangmei Shen, Shile Huang

Published Jun 10, 2025 · Vol. 16, No. 1 · pp. 425-426

Signaling pathway dysregulation in breast cancer Review

Dinara Ryspayeva, Attila A. Seyhan, William J. MacDonald, Connor Purcell, Tyler J. Roady, Maryam Ghandali, Nataliia Verovkina, Wafik S. El-Deiry, Martin S. Taylor, Stephanie L. Graff

Published Mar 7, 2025 · Vol. 16, No. 1 · pp. 168-201

Keywords: breast cancer, oncogenic pathways, signal dysregulation in cancer, therapeutic approaches, clinical trials

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

Laurence Booth, Jane L. Roberts, Ivan Spasojevic, Kaitlyn C. Baker, Andrew Poklepovic, Cameron West, John M. Kirkwood, Paul Dent

Published May 9, 2024 · Vol. 15, No. 1 · pp. 328-344

Keywords: autophagy, ER stress, GZ17-6.02, doxorubicin, afatinib, neratinib

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 159-174

Keywords: autophagy, ER stress, GZ17-6.02, bortezomib, proteasome inhibitor

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

Michael R. Booth, Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 124-133

Keywords: autophagy, ER stress, GZ17-6.02, bexarotene, vorinostat

G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis Research Paper

Monalisa Parija, Amit K. Adhya, Sandip K. Mishra

Published May 11, 2023 · Vol. 14, No. 1 · pp. 466-480

Keywords: G-protein-coupled receptor 141, cell migration, metastasis, p-mTOR, p53

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

Md Maksudul Alam, Janmaris Marin Fermin, Mark Knackstedt, Mackenzie J. Noonan, Taylor Powell, Landon Goodreau, Emily K. Daniel, Xiaohua Rong, Tara Moore-Medlin, Alok R. Khandelwal, Cherie-Ann O. Nathan

Published Jan 27, 2023 · Vol. 14, No. 1 · pp. 85-95

Keywords: TP53 mutant, HNSCC, angiogenesis, everolimus, mTOR

GZ17-6.02 and axitinib interact to kill renal carcinoma cells Research Paper

Laurence Booth, Cameron West, Robert P. Moore, Daniel Von Hoff, Paul Dent

Published Jan 28, 2022 · Vol. 13, No. 1 · pp. 281-290

Keywords: GZ17-6.02, axitinib, renal cell carcinoma, autophagy, HDAC

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Sukhmani K. Padda, Yesim Gökmen-Polar, Jessica A. Hellyer, Sunil S. Badve, Neeraj K. Singh, Sumanth M. Vasista, Kabya Basu, Ansu Kumar, Heather A. Wakelee

Published May 21, 2021 · Vol. 12, No. 12 · pp. 1178-1186

Keywords: thymic epithelial tumor, thymoma, genomics, clustering, computational analysis

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

Sateja Paradkar, James Herrington, Adam Hendricson, Piyasena Hewawasam, Mark Plummer, Denton Hoyer, Ranjini K. Sundaram, Yulia V. Surovtseva, Ranjit S. Bindra

Published Mar 27, 2021 · Vol. 12, No. 9 · pp. 891-906

Keywords: glioblastoma, radiosensitizers, mibefradil, DNA repair, alternative non-homologous end joining

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Elodie Montaudon, Rania El Botty, Sophie Vacher, Olivier Déas, Adnan Naguez, Sophie Chateau-Joubert, Damien Treguer, Ludmilla de Plater, Leïla Zemoura, Fariba Némati, André Nicolas, Alain Chapelier, Alain Livartowski, Stefano Cairo, Catherine Daniel, Marie Brevet, Elisabetta Marangoni, Didier Meseure, Sergio Roman-Roman, Ivan Bieche, Nicolas Girard, Didier Decaudin

Published Mar 26, 2021 · Vol. 12, No. 8 · pp. 859-872

Keywords: NSCLC, Pi3K signalling pathway, mTORC1, RAD001 (everolimus), PLK1

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Christelle Morris, Sébastien Durand, Pierre Jalinot

Published Mar 13, 2021 · Vol. 12, No. 7 · pp. 649-664

Keywords: breast cancer, senescence-associated secretory phenotype, eIF3, PARP1, mTORC1

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1 Research Paper

Erik L. Brincks, James Adams, Lifu Wang, Benjamin Turner, Agnieszka Marcinowicz, Jiyuan Ke, Michael Essmann, Lucía M. Mautino, Clarissa Van Allen, Sanjeev Kumar, Nicholas Vahanian, Charles Link, Mario R. Mautino

Published Jun 9, 2020 · Vol. 11, No. 25 · pp. 2438-2461

Keywords: indoximod, IDO, TDO, AhR, mTORC1

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Boxiao Ding, Alexander Haidurov, Ayesha Chawla, Anita Parmigiani, Gerarda van de Kamp, Alexandra Dalina, Fang Yuan, Jun Hee Lee, Peter M. Chumakov, Steven R. Grossman, Andrei V. Budanov

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6997-7009

Keywords: SESTRINs, lung cancer, mouse model, mTORC1/2, tumor suppression

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers Research Paper

Michelle M. Williams, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez, Rebecca S. Cook

Published Sep 10, 2019 · Vol. 10, No. 52 · pp. 5389-5402

Keywords: Mcl-1, ABT-263 resistance, mTORC1 signaling, luminal breast cancers

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Nicci Owusu-Brackett, Kurt W. Evans, Argun Akcakanat, Erkan Yuca, Coya Tapia, Yasmeen Qamar Rizvi, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5011-5019

Keywords: breast cancer, TAK228, PI3K, PTEN, TNBC

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss Research Paper

Amro H. Mohammad, Sarah Assadian, Frédéric Couture, Karen J. Lefebvre, Wissal El-Assaad, Veronique Barrès, Veronique Ouellet, Pierre-Luc Boulay, Jieyi Yang, Mathieu Latour, Luc Furic, William Muller, Nahum Sonenberg, Anne-Marie Mes-Masson, Fred Saad, Robert Day, Jose G. Teodoro

Published Aug 13, 2019 · Vol. 10, No. 48 · pp. 4923-4936

Keywords: prostate cancer, PTEN, prorenin receptor, soluble prorenin receptor, V-ATPase complex

EGFR and mTOR as therapeutic targets in glioblastoma Editorial

Michael W. Ronellenfitsch, Anna-Luisa Luger, Joachim P. Steinbach

Published Jul 10, 2019 · Vol. 10, No. 46 · pp. 4721-4723

Keywords: glioblastoma, EGFR, mTOR, DDIT4, tumor microenvironment

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

Osamu Ichiyanagi, Hiromi Ito, Sei Naito, Takanobu Kabasawa, Hidenori Kanno, Takafumi Narisawa, Masaki Ushijima, Yuta Kurota, Michinobu Ozawa, Toshihiko Sakurai, Hayato Nishida, Tomoyuki Kato, Mitsunori Yamakawa, Norihiko Tsuchiya

Published Jun 18, 2019 · Vol. 10, No. 40 · pp. 4053-4068

Keywords: renal cell carcinoma, phospho-eIF4E (p-eIF4E), MNK (MAPK-interacting kinase), recurrence-free, epithelial−mesenchymal transition

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The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Signaling pathway dysregulation in breast cancer Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis Research Paper

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

GZ17-6.02 and axitinib interact to kill renal carcinoma cells Research Paper

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1 Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss Research Paper

EGFR and mTOR as therapeutic targets in glioblastoma Editorial

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Signaling pathway dysregulation in breast cancer Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis Research Paper

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

GZ17-6.02 and axitinib interact to kill renal carcinoma cells Research Paper

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1 Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss Research Paper

EGFR and mTOR as therapeutic targets in glioblastoma Editorial

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper