The Oncosearch | Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Tayo A. Adeyika, Anju Datturgi, Yehnara Ettinoffe, Somiranjan Ghosh, Christopher Albanese, Bernard Kwabi-Addo

Published Apr 1, 2026 · Vol. 17, No. 1 · pp. 157-172

Keywords: PDX1, DNA methylation prostate cancer, shRNA knockdown, over-expression, glucose

Correction: Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Correction

Devalingam Mahalingam, Salih Hanni, Anthony V. Serritella, Christos Fountzilas, Joel Michalek, Brian Hernandez, John Sarantopoulos, Paromitta Datta, Ofelia Romero, Sureshkumar Mulampurath Achutan Pillai, John Kuhn, Michael Pollak, Ian M. Thompson

Published Oct 13, 2023 · Vol. 14, No. 1 · pp. 890-892

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

Devalingam Mahalingam, Salih Hanni, Anthony V. Serritella, Christos Fountzilas, Joel Michalek, Brian Hernandez, John Sarantopoulos, Paromitta Datta, Ofelia Romero, Sureshkumar Mulampurath Achutan Pillai, John Kuhn, Michael Pollak, Ian M. Thompson

Published Jun 8, 2023 · Vol. 14, No. 1 · pp. 622-636

Keywords: prostate cancer, metformin, metastatic, androgen deprivation therapy, clinical trial

Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more Review

Masahiko Shibata, Kotaro Nanno, Daigo Yoshimori, Takahiro Nakajima, Makoto Takada, Takashi Yazawa, Kousaku Mimura, Norio Inoue, Takafumi Watanabe, Kazunoshin Tachibana, Satoshi Muto, Tomoyuki Momma, Yoshiyuki Suzuki, Koji Kono, Shungo Endo, Seiichi Takenoshita

Published Oct 25, 2022 · Vol. 13, No. 1 · pp. 1273-1285

Keywords: MDSC, immunosuppression, Treg, TAM, cancer

In vitro chemotherapy-associated muscle toxicity is attenuated with nutritional support, while treatment efficacy is retained Research Paper

Liza A. Wijler, Francina J. Dijk, Hanil Quirindongo, Danielle A.E. Raats, Bram Dorresteijn, Matthew J.W. Furber, Anne M. May, Onno Kranenburg, Miriam van Dijk

Published Sep 27, 2022 · Vol. 13, No. 1 · pp. 1094-1108

Keywords: C2C12 myotubes, chemotherapy, chemotherapy-associated toxicity, colorectal cancer, nutrients, tumor (organoid) cells

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

Mark B. Ulanja, Alastair E. Moody, Bryce D. Beutler, Daniel Antwi-Amoabeng, Ganiyu A. Rahman, Olatunji B. Alese

Published Jun 4, 2022 · Vol. 13, No. 1 · pp. 828-841

Keywords: pancreatic cancer, gastrointestinal malignancy, epidemiology, pancreatic adenocarcinoma

Patient-derived tumor models are attractive tools to repurpose drugs for ovarian cancer treatment: pre-clinical updates Review

Magdalena Cybula, Magdalena Bieniasz

Published Mar 11, 2022 · Vol. 13, No. 1 · pp. 553-575

Keywords: PDX, ovarian cancer, repurposed drugs, tumor models

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

Alexander W. Pohlman, Hita Moudgalya, Lia Jordano, Gabriela C. Lobato, David Gerard, Michael J. Liptay, Christopher W. Seder, Jeffrey A. Borgia

Published Feb 15, 2022 · Vol. 13, No. 1 · pp. 393-407

Keywords: IGF, lung cancer, biomarkers, screening, prognostication

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Alice Augenlicht, Manuel Saiselet, Myriam Decaussin-Petrucci, Guy Andry, Jacques E. Dumont, Carine Maenhaut

Published Jul 17, 2021 · Vol. 12, No. 16 · pp. 1587-1599

Keywords: miRNA, papillary thyroid carcinoma, IRS2, MAPK, PI3K

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

Yehia I. Mohamed, Sunyoung Lee, Lianchun Xiao, Manal M. Hassan, Aliya Qayyum, Rikita Hiatia, Roberto Carmagnani Pestana, Abedul Haque, Bhawana George, Asif Rashid, Dan G. Duda, Hesham Elghazaly, Robert A. Wolff, Jeffrey S. Morris, James Yao, Hesham M. Amin, Ahmed O. Kaseb

Published Mar 13, 2021 · Vol. 12, No. 8 · pp. 756-766

Keywords: IGF-1, Child-Pugh, sorafenib, liver reserve, hepatocellular carcinoma

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Jackie Bader, Meredith Carson, Reilly Enos, Kandy Velazquez, Alexander Sougiannis, Udai Singh, William Becker, Mitzi Nagarkatti, Daping Fan, Angela Murphy

Published Nov 24, 2020 · Vol. 11, No. 49 · pp. 4554-4569

Keywords: colorectal cancer, obesity, metabolism, macrophage, inflammation

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Justyna Magdalena Hermanowicz, Iwona Kwiatkowska, Dariusz Pawlak

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3078-3101

Keywords: modulators of carcinogenesis, acetylcholine, peroxisome proliferator-activated receptors, aquaporins

Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma Research Paper

Rina Fujiwara-Tani, Takamitsu Sasaki, Kiyomu Fujii, Yi Luo, Takuya Mori, Shingo Kishi, Shiori Mori, Sayako Matsushima-Otsuka, Yukiko Nishiguchi, Kei Goto, Isao Kawahara, Masuo Kondoh, Masayuki Sho, Hiroki Kuniyasu

Published Jun 30, 2020 · Vol. 11, No. 31 · pp. 2982-2994

Keywords: diabetes, liver metastasis, colorectal cancer, biglycan, mesenchymal stem cell

Rapid onset type 1 diabetes with anti-PD-1 directed therapy Research Paper

Karen Yun, Gregory Daniels, Kathryn Gold, Karen Mccowen, Sandip Pravin Patel

Published Jun 23, 2020 · Vol. 11, No. 28 · pp. 2740-2746

Keywords: type 1 diabetes, diabetic ketoacidosis (DKA), immune-related adverse event (irAE), immunotherapy, PD-1 inhibitors

Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice Research Paper

Eugenia Y. Xu, Evan Vosburgh, Chung Wong, Laura H. Tang, Daniel A. Notterman

Published Jun 20, 2020 · Vol. 11, No. 28 · pp. 2718-2739

Keywords: neuroendocrine tumors, RB1, Trp53, PTEN, Men1

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Rive Sarfstein, Haim Werner

Published Jun 9, 2020 · Vol. 11, No. 25 · pp. 2424-2437

Keywords: insulin, insulin-like growth factor-1 (IGF1), insulin receptor, IGF1 receptor, p53

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Mai Ahmed Shafei, Thomas Forshaw, Jasmine Davis, Arwa Flemban, David Qualtrough, Sarah Dean, Claire Perks, Ming Dong, Robert Newman, Myra Elizabeth Conway

Published May 8, 2020 · Vol. 11, No. 21 · pp. 1971-1987

Keywords: BCAT, PI3K-AKT, ERK, breast cancer

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Wen Luo, Changxin Xu, Sarah Phillips, Aliza Gardenswartz, Jeremy M. Rosenblum, Janet Ayello, Stephen L. Lessnick, Huai-Xiang Hao, Mitchell S. Cairo

Published Apr 16, 2020 · Vol. 11, No. 19 · pp. 1691-1704

Keywords: PPP1R1A, cell cycle control, IGF-1R, metastasis, Ewing sarcoma

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

Tali Sinai-Livne, Metsada Pasmanik-Chor, Zoya Cohen, Ilan Tsarfaty, Haim Werner, Raanan Berger

Published Apr 13, 2020 · Vol. 11, No. 17 · pp. 1515-1530

Keywords: insulin-like growth factor-1 (IGF1), IGF1 receptor (IGF1R), targeted therapy, breast cancer, proteomic analysis

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper

Rizwanul Haque, Shamsuzzama, Lalit Kumar, Tanuj Sharma, Soobiya Fatima, Pooja Jadiya, Mohammad I. Siddiqi, Aamir Nazir

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 634-649

Keywords: Parkinson’s, human insulin, aggregation, Daf-2, Caenorhabditis elegans (C. elegans)

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Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Correction: Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Correction

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more Review

In vitro chemotherapy-associated muscle toxicity is attenuated with nutritional support, while treatment efficacy is retained Research Paper

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

Patient-derived tumor models are attractive tools to repurpose drugs for ovarian cancer treatment: pre-clinical updates Review

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma Research Paper

Rapid onset type 1 diabetes with anti-PD-1 directed therapy Research Paper

Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Correction: Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Correction

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more Review

In vitro chemotherapy-associated muscle toxicity is attenuated with nutritional support, while treatment efficacy is retained Research Paper

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

Patient-derived tumor models are attractive tools to repurpose drugs for ovarian cancer treatment: pre-clinical updates Review

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma Research Paper

Rapid onset type 1 diabetes with anti-PD-1 directed therapy Research Paper

Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper