The Oncosearch | Oncotarget

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Valeriy Domenyuk, Kasey Benson, Peggy Carter, Daniel Magee, Jian Zhang, Nitin Bhardwaj, Hongseok Tae, James Wacker, Foram Rathi, Siobhan Miick, Aastha Kohli, Joshua Carroll, Lori Cuyugan, Evelyn Perez, Wayeesha Zhang, John Collins, Patrick Kennedy, Jeremy Ellis, Adam Stark, Andrey Loskutov, Brittany Cuttone, Blake Taylor, Rebecca Feldman, Jeff Swenson, David Bryant, Robert Hahn-Lowry, Raunaq Kaushal, Jennifer R. Ribeiro, Jim Abraham, Milan Radovich, George W. Sledge, Matthew Oberley, David Spetzler

Published Aug 6, 2025 · Vol. 16, No. 1 · pp. 642-659

Keywords: companion diagnostic, molecular profiling, solid tumors, precision oncology, next-generation sequencing

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Helen Qian, Heba Ali, Vivekanudeep Karri, Justin T. Low, David M. Ashley, Amy B. Heimberger, Lucy A. Godley, Adam M. Sonabend, Crismita Dmello

Published Jun 5, 2025 · Vol. 16, No. 1 · pp. 445-453

Keywords: CHEK2, immune checkpoint inhibitors, immunomodulation

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Reem Ali, Mashael Algethami, Amera Sheha, Shatha Alqahtani, Ahmad Altayyar, Ayat Lashen, Emad Rakha, Abdallah Alhaj Sulaiman, Srinivasan Madhusudan, Dindial Ramotar

Published May 3, 2025 · Vol. 16, No. 1 · pp. 362-378

Keywords: redox signaling, homologous recombination, protein interaction, cell cycle, protein modification

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, Borje S. Andersson

Published May 25, 2024 · Vol. 15, No. 1 · pp. 361-373

Keywords: decitabine, HDAC inhibitors, pancreatic cancer, PARP inhibitors, synergistic cytotoxicity

Transformation-associated recombination (TAR) cloning and its applications for gene function; genome architecture and evolution; biotechnology and biomedicine Review

Natalay Kouprina, Vladimir Larionov

Published Dec 19, 2023 · Vol. 14, No. 1 · pp. 1009-1033

Keywords: transformation-associated recombination, TAR, microbes, biomedicine, biotechnology

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair Research Paper

Jianli Zhou, Drew Sturtevant, Cassie Love, Aditya Kulkarni, Neha Biyani, Umesh Kathad, Elizabeth Thacker, Sandeep Dave, Kishor Bhatia

Published Jun 5, 2023 · Vol. 14, No. 1 · pp. 597-611

Keywords: non-Hodgkin's lymphoma, DNA damage, homologous recombination repair, transcription-coupled nucleotide excision repair, ATM

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

Daiki Ueno, Juan C. Vasquez, Amrita Sule, Jiayu Liang, Jinny van Doorn, Ranjini Sundaram, Sam Friedman, Randy Caliliw, Shinji Ohtake, Xun Bao, Jing Li, Huihui Ye, Karla Boyd, Rong Rong Huang, Jack Dodson, Paul Boutros, Ranjit S. Bindra, Brian Shuch

Published Sep 3, 2022 · Vol. 13, No. 1 · pp. 1054-1067

Keywords: FH, SDHB, renal cell carcinoma, PARP inhibitor, temozolomide

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Karen Cravero, Morgan V. Pantone, Dong Ho Shin, Riley Bergman, Rory Cochran, David Chu, Daniel J. Zabransky, Swathi Karthikeyan, Ian G. Waters, Natasha Hunter, D. Marc Rosen, Kelly Kyker-Snowman, W. Brian Dalton, Berry Button, Dan Shinn, Hong Yuen Wong, Joshua Donaldson, Paula J. Hurley, Sarah Croessmann, Ben Ho Park

Published Feb 11, 2022 · Vol. 13, No. 1 · pp. 373-386

Keywords: NOTCH1, TNBC, breast cancer, PEST

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Subhamoy Datta, Manthan Patel, Sukesh Kashyap, Divyesh Patel, Umashankar Singh

Published Dec 24, 2021 · Vol. 13, No. 1 · pp. 136-155

Keywords: CGGBP1, non-homologous chromosomal chimeras, methylation, heat stress, repeats

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Subhamoy Datta, Manthan Patel, Sukesh Kashyap, Divyesh Patel, Umashankar Singh

Published Dec 24, 2021

Keywords: CGGBP1, non-homologous chromosomal chimeras, methylation, heat stress, repeats

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Lara H. El Touny, Curtis Hose, John Connelly, Erik Harris, Anne Monks, Angie B. Dull, Deborah F. Wilsker, Melinda G. Hollingshead, Michelle Gottholm-Ahalt, Sergio Y. Alcoser, Michael E. Mullendore, Ralph E. Parchment, James H. Doroshow, Beverly A. Teicher, Annamaria Rapisarda

Published Sep 28, 2021 · Vol. 12, No. 21 · pp. 2114-2130

Keywords: TMZ, MMR, ATR, HR, REV3L

Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication Research Paper

Mario Scarpa, Shivani Kapoor, Eric S. Tvedte, Kshama A. Doshi, Ying S. Zou, Prerna Singh, Jonelle K. Lee, Aditi Chatterjee, Moaath K. Mustafa Ali, Robin E. Bromley, Julie C. Dunning Hotopp, Feyruz V. Rassool, Maria R. Baer

Published Aug 2, 2021 · Vol. 12, No. 18 · pp. 1763-1779

Keywords: FLT3 internal tandem duplication, Pim kinase, alternative non-homologous end-joining DNA repair, genomic instability, topoisomerase 2 inhibitors

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

Alexander Chota, Blassan P. George, Heidi Abrahamse

Published Jul 19, 2021 · Vol. 12, No. 16 · pp. 1615-1626

Keywords: apoptosis, caspases, cancer, Bcl-2 family proteins, p53

Genetic testing for homologous recombination repair (HRR) in metastatic castration-resistant prostate cancer (mCRPC): challenges and solutions Review

Rodney J. Scott, Anurag Mehta, Gabriel S. Macedo, Pavel S. Borisov, Ravindran Kanesvaran, Wafaa El Metnawy

Published Jun 22, 2021 · Vol. 12, No. 16 · pp. 1600-1614

Keywords: metastatic castration-resistant prostate cancer, homologous recombination repair, next generation sequencing, genetic testing

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

Rami Mäkelä, Ville Härmä, Nibal Badra Fajardo, Greg Wells, Zoi Lygerou, Olle Sangfelt, Juha Kononen, Juha K. Rantala

Published May 6, 2021 · Vol. 12, No. 11 · pp. 1100-1109

Keywords: cutaneous apocrine sweat gland carcinoma, ex vivo drug screening, DNA repair, PALB2, rare cancer

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

Sateja Paradkar, James Herrington, Adam Hendricson, Piyasena Hewawasam, Mark Plummer, Denton Hoyer, Ranjini K. Sundaram, Yulia V. Surovtseva, Ranjit S. Bindra

Published Mar 27, 2021 · Vol. 12, No. 9 · pp. 891-906

Keywords: glioblastoma, radiosensitizers, mibefradil, DNA repair, alternative non-homologous end joining

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Christelle Morris, Sébastien Durand, Pierre Jalinot

Published Mar 13, 2021 · Vol. 12, No. 7 · pp. 649-664

Keywords: breast cancer, senescence-associated secretory phenotype, eIF3, PARP1, mTORC1

Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer Research Paper

Thomas M. Cardillo, Diane L. Rossi, Maria B. Zalath, Donglin Liu, Roberto Arrojo, Robert M. Sharkey, Chien-Hsing Chang, David M. Goldenberg

Published Oct 1, 2020 · Vol. 11, No. 43 · pp. 3849-3862

Keywords: sacituzumab govitecan, Trop-2, biomarker, RAD51, triple-negative breast cancer

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line Research Paper

Masaki Kobayashi, Yuka Ishizaki, Mika Owaki, Yoko Matsumoto, Yuri Kakiyama, Shunsuke Hoshino, Ryoma Tagawa, Yuka Sudo, Naoyuki Okita, Kazunori Akimoto, Yoshikazu Higami

Published Apr 22, 2020 · Vol. 11, No. 18 · pp. 1653-1665

Keywords: nutlin-3a, PARP1, breast cancer, proteasomal degradation, autoPARylation

Correction: Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model Correction

Gerben R. Borst, Ramya Kumareswaran, Hatice Yücel, Seyda Telli, Trevor Do, Trevor McKee, Gaetano Zafarana, Jos Jonkers, Marcel Verheij, Mark J. O’Connor, Sven Rottenberg, Robert G. Bristow

Published Jan 28, 2020 · Vol. 11, No. 17 · pp. 1573-1574

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Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Transformation-associated recombination (TAR) cloning and its applications for gene function; genome architecture and evolution; biotechnology and biomedicine Review

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair Research Paper

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication Research Paper

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

Genetic testing for homologous recombination repair (HRR) in metastatic castration-resistant prostate cancer (mCRPC): challenges and solutions Review

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer Research Paper

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line Research Paper

Correction: Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model Correction

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Transformation-associated recombination (TAR) cloning and its applications for gene function; genome architecture and evolution; biotechnology and biomedicine Review

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair Research Paper

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMTlow/MMRproficient cancer cells to temozolomide Priority Research Paper

Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication Research Paper

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

Genetic testing for homologous recombination repair (HRR) in metastatic castration-resistant prostate cancer (mCRPC): challenges and solutions Review

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer Research Paper

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line Research Paper

Correction: Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model Correction

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper