The Oncosearch | Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Tayo A. Adeyika, Anju Datturgi, Yehnara Ettinoffe, Somiranjan Ghosh, Christopher Albanese, Bernard Kwabi-Addo

Published Apr 1, 2026 · Vol. 17, No. 1 · pp. 157-172

Keywords: PDX1, DNA methylation prostate cancer, shRNA knockdown, over-expression, glucose

Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma Research Paper

Jacob Haagsma, Yudith Ramos Valdes, Xuejin Ou, Rasheduzzaman Rashu, S.M. Mansour Haeryfar, Jim Petrik, Trevor G. Shepherd

Published Sep 16, 2025 · Vol. 16, No. 1 · pp. 697-718

Keywords: high-grade serous ovarian carcinoma, orthotopic models, inflammation, microenvironment

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Kristen Kwong, Yue Pan, Jacqueline Morales, Matthew Watson, David V. Allegakoen, Alex G. Lee, Trever G. Bivona, Peter Wipf, Christopher J. Guerriero, Jeffrey L. Brodsky, Amit J. Sabnis

Published Aug 23, 2025 · Vol. 16, No. 1 · pp. 681-696

Keywords: protein homeostasis, rhabdomyosarcoma, unfolded protein response, preclinical therapeutics, p97

Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer Research Paper

Shailender S. Chauhan, Andres D. Vizzerra, Hope Liou, Caitlyn E. Flores, Ashley J. Snider, Justin M. Snider, Noel A. Warfel

Published Jun 18, 2025 · Vol. 16, No. 1 · pp. 532-544

Keywords: hypoxia, lipid droplets, ferroptosis, resistance, prostate

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Jennifer A. Heritz, Sarah J. Backe,, Mehdi Mollapour

Published Sep 21, 2024 · Vol. 15, No. 1 · pp. 679-696

Keywords: molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, Peter M. Glazer

Published Sep 20, 2024 · Vol. 15, No. 1 · pp. 699-713

Keywords: 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

Jun Zhang, Lanlan Zhou, Shuai Zhao, Wafik S. El-Deiry

Published Jun 24, 2024 · Vol. 15, No. 1 · pp. 424-438

Keywords: TAS102, regorafenib, ERK1/2, angiogenesis, microvessel density

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 159-174

Keywords: autophagy, ER stress, GZ17-6.02, bortezomib, proteasome inhibitor

Role of the prorenin receptor in endometrial cancer cell growth Research Paper

Jacinta H. Martin, Riazuddin Mohammed, Sarah J. Delforce, David A. Skerrett-Byrne, Celine Corbisier de Meaultsart, Juhura G. Almazi, Andrew N. Stephens, Nicole M. Verrills, Evdokia Dimitriadis, Yu Wang, Eugenie R. Lumbers, Kirsty G. Pringle

Published Mar 23, 2022 · Vol. 13, No. 1 · pp. 587-599

Keywords: (P)RR, ATP6AP2, endometrial cancer, cellular viability, cellular proliferation

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Karen Cravero, Morgan V. Pantone, Dong Ho Shin, Riley Bergman, Rory Cochran, David Chu, Daniel J. Zabransky, Swathi Karthikeyan, Ian G. Waters, Natasha Hunter, D. Marc Rosen, Kelly Kyker-Snowman, W. Brian Dalton, Berry Button, Dan Shinn, Hong Yuen Wong, Joshua Donaldson, Paula J. Hurley, Sarah Croessmann, Ben Ho Park

Published Feb 11, 2022 · Vol. 13, No. 1 · pp. 373-386

Keywords: NOTCH1, TNBC, breast cancer, PEST

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Subhamoy Datta, Manthan Patel, Sukesh Kashyap, Divyesh Patel, Umashankar Singh

Published Dec 24, 2021 · Vol. 13, No. 1 · pp. 136-155

Keywords: CGGBP1, non-homologous chromosomal chimeras, methylation, heat stress, repeats

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Subhamoy Datta, Manthan Patel, Sukesh Kashyap, Divyesh Patel, Umashankar Singh

Published Dec 24, 2021

Keywords: CGGBP1, non-homologous chromosomal chimeras, methylation, heat stress, repeats

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

Elham Khosrowabadi, Tomasz Wenta, Salla Keskitalo, Aki Manninen, Sakari Kellokumpu

Published Dec 22, 2021 · Vol. 13, No. 1 · pp. 73-89

Keywords: cancer, invasion, glycosylation, glycocode, terminal GalNAc, Helix Pomatia agglutinin (HPA)

RASAL2 suppresses the proliferative and invasive ability of PC3 prostate cancer cells Research Paper

Krishma Tailor, Joseph Paul, Somiranjan Ghosh, Namita Kumari, Bernard Kwabi-Addo

Published Dec 15, 2021 · Vol. 12, No. 26 · pp. 2489-2499

Keywords: RASAL2, Ras-protooncogene, prostate cancer, TNFα signal, DNA methylation

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Lara H. El Touny, Curtis Hose, John Connelly, Erik Harris, Anne Monks, Angie B. Dull, Deborah F. Wilsker, Melinda G. Hollingshead, Michelle Gottholm-Ahalt, Sergio Y. Alcoser, Michael E. Mullendore, Ralph E. Parchment, James H. Doroshow, Beverly A. Teicher, Annamaria Rapisarda

Published Sep 28, 2021 · Vol. 12, No. 21 · pp. 2114-2130

Keywords: TMZ, MMR, ATR, HR, REV3L

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

Ilyas Sahin, Andrew George, Shengliang Zhang, Kelsey E. Huntington, Zehra Ordulu, Lanlan Zhou, Wafik S. El-Deiry

Published Sep 24, 2021 · Vol. 12, No. 21 · pp. 2131-2146

Keywords: cancer immunotherapy, immune checkpoint inhibitors, hyperprogressive disease (HPD), hyperprogression (HP), humanized mouse

A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs Research Paper

Kelsey E. Huntington, Anna Louie, Lanlan Zhou, Wafik S. El-Deiry

Published Sep 11, 2021 · Vol. 12, No. 20 · pp. 1980-1991

Keywords: cytokine profiling, inflammatory response, chemokine, growth factor, immune profiling

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer Research Paper

Brenna M. Zimmer, Michelle E. Howell, Linlin Ma, Jeffrey R. Enders, Danielle Lehman, Eva Corey, Joseph J. Barycki, Melanie A. Simpson

Published Aug 19, 2021 · Vol. 12, No. 19 · pp. 1886-1902

Keywords: prostate cancer, castration resistance, detoxification, UDP-glucose dehydrogenase, patient-derived xenografts

Abstract_headers_test_v1_The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

Marina Simón, Jesper Tranekjær Jørgensen, Karina Juhl, Andreas Kjaer

Published Aug 3, 2021

Keywords: photothermal therapy (PTT), indocyanine green (ICG), urokinase plasminogen activator receptor (uPAR), cancer, hyperthermia

JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA Research Paper

Subarna Ghosh, Priyanka Dey Talukdar, Abhinandan Bhattacharjee, Sarbani Giri, Nitai Pada Bhattacharyya, Urmi Chatterji

Published Jul 2, 2021 · Vol. 12, No. 15 · pp. 1520-1539

Keywords: arecoline, tight junction, head and neck cancer, lncRNA-NEAT1, JunD

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Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma Research Paper

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer Research Paper

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Role of the prorenin receptor in endometrial cancer cell growth Research Paper

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

RASAL2 suppresses the proliferative and invasive ability of PC3 prostate cancer cells Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs Research Paper

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer Research Paper

Abstract_headers_test_v1_The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma Research Paper

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer Research Paper

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Role of the prorenin receptor in endometrial cancer cell growth Research Paper

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 Research Paper

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

RASAL2 suppresses the proliferative and invasive ability of PC3 prostate cancer cells Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMTlow/MMRproficient cancer cells to temozolomide Priority Research Paper

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs Research Paper

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer Research Paper

Abstract_headers_test_v1_The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper