The Oncosearch | Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, Susan E. Waltz

Published Jun 16, 2025 · Vol. 16, No. 1 · pp. 508-530

Keywords: EGFR, RTKs, breast cancer, head and neck cancer, resistance mechanisms

Could Panitumumab with very low dose Capecitabine be an option as a maintenance regimen Research Paper

Doaa A. Gamal, Aiat Morsy, Mervat Omar

Published Jan 29, 2025 · Vol. 16, No. 1 · pp. 67-78

Keywords: Panitumumab, maintenance, colorectal cancer, Capecitabine

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Whitney L. Hensing, Emily L. Podany, James J. Sears, Shaili Tapiavala, Andrew A. Davis

Published Jan 9, 2025 · Vol. 16, No. 1 · pp. 11-27

Keywords: breast cancer, HER2-low, genomics

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Thomas M. Cardillo, Maria B. Zalath, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Chien-Hsing Chang, David M. Goldenberg

Published Jan 30, 2024 · Vol. 15, No. 1 · pp. 144-158

Keywords: sacituzumab govitecan, Trop-2, SN-38, carboplatin, cisplatin

Effectiveness and toxicity of cetuximab with concurrent RT in locally advanced cutaneous squamous cell skin cancer: a case series Research Paper

Mark Chang, Wolfram Samlowski, Raul Meoz

Published Jun 22, 2023 · Vol. 14, No. 1 · pp. 709-718

Keywords: keratinocyte carcinoma, squamous cell skin cancer, cetuximab, epidermal growth factor receptor, radiation therapy

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer Research Paper

Romana Moench, Martin Gasser, Karol Nawalaniec, Tanja Grimmig, Amrendra K. Ajay, Larissa Camila Ribeiro de Souza, Minghua Cao, Yueming Luo, Petra Hoegger, Carmen M. Ribas, Jurandir M. Ribas-Filho, Osvaldo Malafaia, Reinhard Lissner, Li-Li Hsiao, Ana Maria Waaga-Gasser

Published Oct 6, 2022 · Vol. 13, No. 1 · pp. 1140-1152

Keywords: PDGF, VEGFR, EGFR, bypassed signaling, colorectal cancer

Targeted elastin-like polypeptide fusion protein for near-infrared imaging of human and canine urothelial carcinoma Research Paper

Aayush Aayush, Saloni Darji, Deepika Dhawan, Alexander Enstrom, Meaghan M. Broman, Muhammad T. Idrees, Hristos Kaimakliotis, Timothy Ratliff, Deborah Knapp, David Thompson

Published Aug 27, 2022 · Vol. 13, No. 1 · pp. 1004-1016

Keywords: bladder cancer, elastin-like polypeptide, NIR imaging, epidermal growth factor receptor (EGFR), translational studies

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Raquel Torres-Guzmán, Maria Patricia Ganado, Cecilia Mur, Carlos Marugan, Carmen Baquero, Yanzhu Yang, Yi Zeng, Huimin Bian, Jian Du, Alfonso de Dios, Oscar Puig, María José Lallena

Published Jun 22, 2022 · Vol. 13, No. 1 · pp. 864-875

Keywords: abemaciclib, breast cancer, cell lines, CDK4/6, continuous dosing

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

Mark B. Ulanja, Alastair E. Moody, Bryce D. Beutler, Daniel Antwi-Amoabeng, Ganiyu A. Rahman, Olatunji B. Alese

Published Jun 4, 2022 · Vol. 13, No. 1 · pp. 828-841

Keywords: pancreatic cancer, gastrointestinal malignancy, epidemiology, pancreatic adenocarcinoma

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Karen Cravero, Morgan V. Pantone, Dong Ho Shin, Riley Bergman, Rory Cochran, David Chu, Daniel J. Zabransky, Swathi Karthikeyan, Ian G. Waters, Natasha Hunter, D. Marc Rosen, Kelly Kyker-Snowman, W. Brian Dalton, Berry Button, Dan Shinn, Hong Yuen Wong, Joshua Donaldson, Paula J. Hurley, Sarah Croessmann, Ben Ho Park

Published Feb 11, 2022 · Vol. 13, No. 1 · pp. 373-386

Keywords: NOTCH1, TNBC, breast cancer, PEST

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

Elham Khosrowabadi, Tomasz Wenta, Salla Keskitalo, Aki Manninen, Sakari Kellokumpu

Published Dec 22, 2021 · Vol. 13, No. 1 · pp. 73-89

Keywords: cancer, invasion, glycosylation, glycocode, terminal GalNAc, Helix Pomatia agglutinin (HPA)

The clinician’s perspective on the 21-gene assay in early breast cancer Review

Francesco Cognetti, Giuseppe Naso

Published Dec 1, 2021 · Vol. 12, No. 26 · pp. 2514-2530

Keywords: Oncotype DX test, recurrence score results, multigene assays, genomic tests, personalized medicine

Comparison of MET gene amplification analysis by next-generation sequencing and fluorescence in situ hybridization Research Paper

Christina Schmitt, Anna-Alice Schulz, Ria Winkelmann, Kevin Smith, Peter J. Wild, Melanie Demes

Published Oct 5, 2021 · Vol. 12, No. 22 · pp. 2273-2282

Keywords: next-generation sequencing (NGS), non-small cell lung cancer (NSCLC), fluorescence in situ hybridization (FISH), MET amplification, routine diagnostics

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer Editorial

Sasagu Kurozumi, Ayaka Katayama, Ken Shirabe, Jun Horiguchi, Emad A. Rakha

Published Jun 19, 2021 · Vol. 12, No. 22 · pp. 2302-2304

Keywords: breast cancer, HER2 low, triple negative, heterogeneity

Association between miRNA signatures in serum samples from epidermal growth factor inhibitor treated patients and skin toxicity Research Paper

Sarah Kemski, Vivien Molitor, Michael Steffens, Tim J. Nümm, Nadine Herrmann, Thorsten Hornung, Thomas Bieber, Christian Schumann, Volker Kächele, Thomas Seufferlein, Volker Heinemann, Catharina Scholl, Julia Carolin Stingl

Published Apr 24, 2021 · Vol. 12, No. 10 · pp. 982-995

Keywords: miRNA, EGFR, EGFRI, cancer, skin toxicity

Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer Research Paper

Radhika R. Gudi, Harinarayanan Janakiraman, Philip H. Howe, Viswanathan Palanisamy, Chenthamarakshan Vasu

Published Mar 27, 2021 · Vol. 12, No. 8 · pp. 807-822

Keywords: tumorigenesis, epithelial-mesenchymal transition, oral squamous cell carcinoma, EGFR, CPAP

Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center Case Report

Marie-Luise Hilbers, Regula Brändli, Beda Mühleisen, Sandra N. Freiberger, Joanna Mangana, Reinhard Dummer

Published Dec 18, 2020 · Vol. 12, No. 2 · pp. 125-130

Keywords: spitzoid nevi, melanocytic lesion, dermatopathology, pediatric dermatology, diagnostic algorithm

Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I–III breast cancer: Multicenter study Research Paper

Kazuhiro Kitajima, Yasuo Miyoshi, Tetsuro Sekine, Hiroyuki Takei, Kimiteru Ito, Akihiko Suto, Hayato Kaida, Kazunari Ishii, Hiromitsu Daisaki, Koichiro Yamakado

Published Dec 16, 2020 · Vol. 12, No. 2 · pp. 95-105

Keywords: breast cancer, survival, fluorodeoxyglucose (FDG), positron emission tomography-computed tomography (PET-CT), harmonization

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

Fleury Augustin Nsole Biteghe, Neelakshi Mungra, Nyangone Ekome Toung Chalomie, Jean De La Croix Ndong, Jean Engohang-Ndong, Guillaume Vignaux, Eden Padayachee, Krupa Naran, Stefan Barth

Published Aug 26, 2020 · Vol. 11, No. 38 · pp. 3531-3557

Keywords: epidermal growth factor receptor (EGFR), recombinant immunotoxins (ITs), targeted human cytolytic fusion proteins (hCFPs), recombinant antibody-drug conjugates (rADCs), recombinant antibody photoimmunoconjugates (rAPCs)

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Justyna Magdalena Hermanowicz, Iwona Kwiatkowska, Dariusz Pawlak

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3078-3101

Keywords: modulators of carcinogenesis, acetylcholine, peroxisome proliferator-activated receptors, aquaporins

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Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Could Panitumumab with very low dose Capecitabine be an option as a maintenance regimen Research Paper

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Effectiveness and toxicity of cetuximab with concurrent RT in locally advanced cutaneous squamous cell skin cancer: a case series Research Paper

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer Research Paper

Targeted elastin-like polypeptide fusion protein for near-infrared imaging of human and canine urothelial carcinoma Research Paper

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

The clinician’s perspective on the 21-gene assay in early breast cancer Review

Comparison of MET gene amplification analysis by next-generation sequencing and fluorescence in situ hybridization Research Paper

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer Editorial

Association between miRNA signatures in serum samples from epidermal growth factor inhibitor treated patients and skin toxicity Research Paper

Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer Research Paper

Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center Case Report

Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I–III breast cancer: Multicenter study Research Paper

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Could Panitumumab with very low dose Capecitabine be an option as a maintenance regimen Research Paper

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Effectiveness and toxicity of cetuximab with concurrent RT in locally advanced cutaneous squamous cell skin cancer: a case series Research Paper

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer Research Paper

Targeted elastin-like polypeptide fusion protein for near-infrared imaging of human and canine urothelial carcinoma Research Paper

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

The clinician’s perspective on the 21-gene assay in early breast cancer Review

Comparison of MET gene amplification analysis by next-generation sequencing and fluorescence in situ hybridization Research Paper

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer Editorial

Association between miRNA signatures in serum samples from epidermal growth factor inhibitor treated patients and skin toxicity Research Paper

Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer Research Paper

Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center Case Report

Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I–III breast cancer: Multicenter study Research Paper

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

Important players in carcinogenesis as potential targets in cancer therapy: an update Review