The Oncosearch | Oncotarget

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Jennifer A. Heritz, Sarah J. Backe,, Mehdi Mollapour

Published Sep 21, 2024 · Vol. 15, No. 1 · pp. 679-696

Keywords: molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Christelle Morris, Sébastien Durand, Pierre Jalinot

Published Mar 13, 2021 · Vol. 12, No. 7 · pp. 649-664

Keywords: breast cancer, senescence-associated secretory phenotype, eIF3, PARP1, mTORC1

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Lacey M. Litchfield, Karsten Boehnke, Manisha Brahmachary, Cecilia Mur, Chen Bi, Jennifer R. Stephens, J. Michael Sauder, Sonia M. Gutiérrez, Ann M. McNulty, Xiang S. Ye, Wenjuan Wu, María José Lallena, Xueqian Gong, Farhana F. Merzoug, Valerie M. Jansen, Sean G. Buchanan

Published Mar 23, 2020 · Vol. 11, No. 17 · pp. 1478-1492

Keywords: abemaciclib, CDK4/6, PIM, mTOR, S6

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

Mark R. Woodford, Michael Hughes, Rebecca A. Sager, Sarah J. Backe, Alexander J. Baker-Williams, Michael S. Bratslavsky, Joseph M. Jacob, Oleg Shapiro, Michael Wong, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5824-5834

Keywords: tuberous sclerosis complex (TSC), Tsc1 (Hamartin), Tsc2 (Tuberin), heat shock protein (Hsp90), bladder cancer

A new drug combination significantly reduces kidney tumor progression in kidney mouse model Priority Research Paper

Sitai Liang, Tiffanie Cuellar, Maciej Nowacki, Bijaya K. Nayak, Lily Dong, Boajie Li, Kumar Sharma, Samy L. Habib

Published Aug 31, 2018 · Vol. 9, No. 68 · pp. 32900-32916

Sporadic renal angiomyolipoma in a patient with Birt-Hogg-DubÃ©: chaperones in pathogenesis Case Report

Rebecca A. Sager, Mark R. Woodford, Oleg Shapiro, Mehdi Mollapour, Gennady Bratslavsky

Published Apr 24, 2018 · Vol. 9, No. 31 · pp. 22220-22229

Mouse genetic background influences whether Hras^G12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma Research Paper

Laura P. Brandt, Joachim Albers, Tomas Hejhal, Svende Pfundstein, Ana Filipa GonÃ§alves, Antonella Catalano, Peter J. Wild, Ian J. Frew

Published Apr 13, 2018 · Vol. 9, No. 28 · pp. 19753-19766

Osteopontinâ€“integrin engagement induces HIF-1Î±â€“TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer Research Paper

Chi-Shuan Fan, Wei-Shone Chen, Li-Li Chen, Chia-Chi Chen, Yu-Ting Hsu, Kee Voon Chua, Horng-Dar Wang, Tze-Sing Huang

Published Dec 22, 2017 · Vol. 9, No. 4 · pp. 4998-5015

1,25-Dihydroxyvitamin D₃ inhibits the proliferation of rat mesangial cells induced by high glucose via DDIT4 Research Paper

Da-Peng Chen, Ye-Ping Ma, Li Zhuo, Zheng Zhang, Gu-Ming Zou, Yue Yang, Hong-Mei Gao, Wen-Ge Li

Published Dec 9, 2017 · Vol. 9, No. 1 · pp. 418-427

Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations Research Paper

Anika Bongaarts, Krinio Giannikou, Roy J. Reinten, Jasper J. Anink, James D. Mills, Floor E. Jansen, Wim G.M. Spliet, Willfred F.A. den Dunnen, Roland Coras, Ingmar BlÃ¼mcke, Werner Paulus, Theresa Scholl, Martha Feucht, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Maria Buccoliero, Chiara Caporalini, Flavio Giordano, Lorenzo Genitori, Figen SÃ¶ylemezoÄŸlu, JosÃ© Pimentel, Mark Nellist, Antoinette Y.N. Schouten-van Meeteren, Anwesha Nag, Angelika MÃ¼hlebner, David J. Kwiatkowski, Eleonora Aronica

Published Sep 8, 2017 · Vol. 8, No. 56 · pp. 95516-95529

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells Priority Research Paper

Hilaire C. Lam, Heng-Jia Liu, Christian V. Baglini, Harilaos Filippakis, Nicola Alesi, Julie Nijmeh, Heng Du, Alicia Llorente Lope, Katherine A. Cottrill, Adam Handen, John M. Asara, David J. Kwiatkowski, Issam Ben-Sahra, William M. Oldham, Stephen Y. Chan, Elizabeth P. Henske

Published Aug 4, 2017 · Vol. 8, No. 39 · pp. 64714-64727

Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells Research Paper

Li-Min Chen, Tian-Jiao Song, Jian-Hong Xiao, Zheng-Hui Huang, Yong Li, Ting-Yan Lin

Published Jul 12, 2017 · Vol. 8, No. 38 · pp. 63911-63922

Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development Research Paper

Li Wang, Zhaofei Ni, Yujie Liu, Shuang Ji, Fuquan Jin, Keguo Jiang, Junfang Ma, Cuiping Ren, Hongbing Zhang, Zhongdong Hu, Xiaojun Zha

Published Jul 4, 2017 · Vol. 8, No. 33 · pp. 54858-54872

Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next-generation sequencing panel Research Paper

Ferga C. Gleeson, Jesse S. Voss, Benjamin R. Kipp, Sarah E. Kerr, John S. Van Arnam, John R. Mills, Cherisse A. Marcou, Amber R. Schneider, Zheng Jin Tu, Michael R. Henry, Michael J. Levy

Published Jun 28, 2017 · Vol. 8, No. 55 · pp. 93464-93475

BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity Research Paper

Hexige Saiyin, Ning Na, Xu Han, Yuan Fang, Yanhua Wu, Wenhui Lou, Xianmei Yang

Published May 18, 2017 · Vol. 8, No. 27 · pp. 44669-44681

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R Priority Research Paper

Harilaos Filippakis, Nicola Alesi, Barbara Ogorek, Julie Nijmeh, Damir Khabibullin, Catherine Gutierrez, Alexander J. Valvezan, James Cunningham, Carmen Priolo, Elizabeth P. Henske

Published Apr 27, 2017 · Vol. 8, No. 24 · pp. 38099-38112

NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinoma Research Paper

Vera Tiedje, Saskia Ting, Thomas Herold, Sarah Synoracki, Soeren Latteyer, Lars C. Moeller, Denise Zwanziger, Martin Stuschke, Dagmar Fuehrer, Kurt Werner Schmid

Published Apr 20, 2017 · Vol. 8, No. 26 · pp. 42613-42620

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2^+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper

Kalin Narov, Jian Yang, Paulina Samsel, Ashley Jones, Julian R. Sampson, Ming Hong Shen

Published Apr 19, 2017 · Vol. 8, No. 35 · pp. 58504-58512

Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer Research Paper

Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Ilaria Cangini, Francesca Pirini, Elisabetta Petracci, Andrea Rocca, Fabio Falcini, Dino Amadori, Daniele Calistri

Published Apr 3, 2017 · Vol. 8, No. 29 · pp. 47064-47075

Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis Research Paper

Xiangke Li, Xiaolei Liu, Linda Zhang, Chenggang Li, Erik Zhang, Wang Ma, Qingxia Fan, Jane J. Yu

Published Mar 30, 2017 · Vol. 8, No. 22 · pp. 36628-36638

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Molecular chaperones: Guardians of tumor suppressor stability and function Review

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

A new drug combination significantly reduces kidney tumor progression in kidney mouse model Priority Research Paper

Sporadic renal angiomyolipoma in a patient with Birt-Hogg-DubÃ©: chaperones in pathogenesis Case Report

Mouse genetic background influences whether Hras^G12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma Research Paper

Osteopontinâ€“integrin engagement induces HIF-1Î±â€“TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer Research Paper

1,25-Dihydroxyvitamin D₃ inhibits the proliferation of rat mesangial cells induced by high glucose via DDIT4 Research Paper

Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations Research Paper

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells Priority Research Paper

Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells Research Paper

Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development Research Paper

Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next-generation sequencing panel Research Paper

BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity Research Paper

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R Priority Research Paper

NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinoma Research Paper

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2^+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper

Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer Research Paper

Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

A new drug combination significantly reduces kidney tumor progression in kidney mouse model Priority Research Paper

Sporadic renal angiomyolipoma in a patient with Birt-Hogg-DubÃ©: chaperones in pathogenesis Case Report

Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma Research Paper

Osteopontinâ€“integrin engagement induces HIF-1Î±â€“TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer Research Paper

1,25-Dihydroxyvitamin D3 inhibits the proliferation of rat mesangial cells induced by high glucose via DDIT4 Research Paper

Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations Research Paper

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells Priority Research Paper

Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells Research Paper

Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development Research Paper

Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next-generation sequencing panel Research Paper

BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity Research Paper

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R Priority Research Paper

NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinoma Research Paper

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper

Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer Research Paper

Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis Research Paper

Mouse genetic background influences whether Hras^G12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma Research Paper

1,25-Dihydroxyvitamin D₃ inhibits the proliferation of rat mesangial cells induced by high glucose via DDIT4 Research Paper

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2^+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper