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Signaling pathway dysregulation in breast cancer Review

Dinara Ryspayeva, Attila A. Seyhan, William J. MacDonald, Connor Purcell, Tyler J. Roady, Maryam Ghandali, Nataliia Verovkina, Wafik S. El-Deiry, Martin S. Taylor, Stephanie L. Graff

Published Mar 7, 2025 · Vol. 16, No. 1 · pp. 168-201

Keywords: breast cancer, oncogenic pathways, signal dysregulation in cancer, therapeutic approaches, clinical trials

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

Mark Lee, Luc GT Morris

Published Dec 15, 2023 · Vol. 15, No. 1 · pp. 36-48

Keywords: thyroid cancer, drug resistance, anaplastic transformation, BRAF inhibitors, PIK3CA

TP53 mutations determined by targeted NGS in breast cancer: a case-control study Research Paper

Angeliki Andrikopoulou, Evangelos Terpos, Spyridoula Chatzinikolaou, Kleoniki Apostolidou, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Meletios-Athanasios Dimopoulos, Flora Zagouri

Published Sep 2, 2021 · Vol. 12, No. 21 · pp. 2206-2214

Keywords: TP53 mutations, next-generation sequencing, biomarker, prognosis, breast cancer

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Sukhmani K. Padda, Yesim Gökmen-Polar, Jessica A. Hellyer, Sunil S. Badve, Neeraj K. Singh, Sumanth M. Vasista, Kabya Basu, Ansu Kumar, Heather A. Wakelee

Published May 21, 2021 · Vol. 12, No. 12 · pp. 1178-1186

Keywords: thymic epithelial tumor, thymoma, genomics, clustering, computational analysis

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

Duna H. Barakeh, Rasha Aljelaify, Yara Bashawri, Amal Almutairi, Fatimah Alqubaishi, Mohammed Alnamnakani, Latifa Almubarak, Abdulrahman Al Naeem, Fatema Almushawah, May Alrashed, Malak Abedalthagafi

Published Feb 27, 2021 · Vol. 12, No. 7 · pp. 686-697

Keywords: breast cancer, PIK3CA, BCa, Saudi Arabia, BRCA

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Charles R. Schutt, Hua Sun, Jaya Sarin Pradhan, Yvonne Saenger, Jessica Ley, Douglas Adkins, Matthew Ingham, Li Ding, Brian A. Van Tine

Published Feb 21, 2021 · Vol. 12, No. 6 · pp. 534-548

Keywords: head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Asim Joshi, Rohit Mishra, Sanket Desai, Pratik Chandrani, Hitesh Kore, Roma Sunder, Supriya Hait, Prajish Iyer, Vaishakhi Trivedi, Anuradha Choughule, Vanita Noronha, Amit Joshi, Vijay Patil, Nandini Menon, Rajiv Kumar, Kumar Prabhash, Amit Dutt

Published Feb 19, 2021 · Vol. 12, No. 6 · pp. 578-588

Keywords: lung squamous carcinoma, genetic alterations, druggable mutations, whole exome sequencing, mass spectrometry

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

Christina Walter, Andreas Hartkopf, Andre Koch, Marion Klaumünzer, Martin Schulze, Eva-Maria Grischke, Florin-Andrei Taran, Sara Brucker, Florian Battke, Saskia Biskup

Published Aug 1, 2020 · Vol. 11, No. 35 · pp. 3279-3285

Keywords: breast cancer, genetics, next-generation sequencing, actionable mutations

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Takeyuki Suzuki, Tetsutaro Suzuki, Yukino Yoshimura, Mitsunori Yahata, Poh Yin Yew, Tetsuya Nakamura, Yusuke Nakamura, Jae-Hyun Park, Ryota Matsuo

Published Jul 15, 2020 · Vol. 11, No. 34 · pp. 3198-3207

Keywords: ctDNA, early detection, liquid biopsy, mutation, recurrence

Blood-based next-generation sequencing analysis of neuroendocrine neoplasms Research Paper

Katerina Zakka, Rebecca Nagy, Leylah Drusbosky, Mehmet Akce, Christina Wu, Olatunji B. Alese, Bassel F. El-Rayes, Pashtoon Murtaza Kasi, Kabir Mody, Jason Starr, Walid L. Shaib

Published Apr 26, 2020 · Vol. 11, No. 19 · pp. 1749-1757

Keywords: neuroendocrine neoplasm, neuroendocrine tumor, neuroendocrine carcinoma, next-generation sequencing, circulating tumor DNA

A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies Research Paper

Matthew H. Taylor, Ajjai S. Alva, Timothy Larson, Sebastian Szpakowski, Das Purkaystha, Alpesh Amin, Linda Karpiak, Sarina A. Piha-Paul

Published Apr 7, 2020 · Vol. 11, No. 14 · pp. 1235-1243

Keywords: advanced malignancies, basket trial, dovitinib, histology-agnostic, mutation-specific

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Lacey M. Litchfield, Karsten Boehnke, Manisha Brahmachary, Cecilia Mur, Chen Bi, Jennifer R. Stephens, J. Michael Sauder, Sonia M. Gutiérrez, Ann M. McNulty, Xiang S. Ye, Wenjuan Wu, María José Lallena, Xueqian Gong, Farhana F. Merzoug, Valerie M. Jansen, Sean G. Buchanan

Published Mar 23, 2020 · Vol. 11, No. 17 · pp. 1478-1492

Keywords: abemaciclib, CDK4/6, PIM, mTOR, S6

Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment Research Paper

Fiamma Buttitta, Lara Felicioni, Alessia Di Lorito, Alessio Cortellini, Luciana Irtelli, Davide Brocco, Pietro Di Marino, Donatella Traisci, Nicola D’Ostilio, Alessandra Di Paolo, Francesco Malorgio, Pasquale Assalone, Sonia Di Felice, Francesca Fabbri, Giovanni Cianci, Michele De Tursi, Antonio Marchetti

Published Mar 17, 2020 · Vol. 11, No. 11 · pp. 982-991

Keywords: epidermal growth factor receptor (EGFR), tyrosine-kinase Inhibitors, circulating tumor-DNA (ct-DNA), massive parallel sequencing (MPS), resistance-inducing mutation

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Richard K. Yang, Yun Qing, Fatima Zahra Jelloul, Mark J. Routbort, Peng Wang, Kenna Shaw, Jiexin Zhang, Jack Lee, L. Jeffrey Medeiros, Scott Kopetz, Michael T. Tetzlaff, Russell R. Broaddus

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 600-618

Keywords: biomarkers, immunotherapy, mutations, TMB, histology

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Beatrice Aramini, Federico Banchelli, Stefania Bettelli, Samantha Manfredini, Roberto D’Amico, Valentina Masciale, Massimo Pinelli, Margherita Moretti, Alessandro Stefani, Federica Bertolini, Massimo Dominici, Uliano Morandi, Antonino Maiorana

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 550-559

Keywords: somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy

Pathogenic mutations and overall survival in 3,084 patients with cancer: the Hellenic Cooperative Oncology Group Precision Medicine Initiative Research Paper

Elena Fountzilas, Vassiliki Kotoula, Georgia-Angeliki Koliou, Eleni Giannoulatou, Helen Gogas, Christos Papadimitriou, Ioannis Tikas, Jianhua Zhang, Kyriaki Papadopoulou, Flora Zagouri, Christos Christodoulou, Angelos Koutras, Thomas Makatsoris, Sofia Chrisafi, Helena Linardou, Ioannis Varthalitis, George Papatsibas, Evangelia Razis, Pavlos Papakostas, Epaminontas Samantas, Gerasimos Aravantinos, Dimitrios Bafaloukos, Paris Kosmidis, Anna Koumarianou, Amanda Psyrri, Georgios Pentheroudakis, Dimitrios Pectasides, Andrew Futreal, George Fountzilas, Apostolia M. Tsimberidou

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 1-14

Keywords: actionable gene, next-generation sequencing, pathogenic mutation, precision oncology, prognosis

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Thierry M. Nordmann, Olivia Messerli-Odermatt, Larissa Meier, Sara Micaletto, Thomas Coppetti, Mirjam Nägeli, Jivko Kamarachev, Ken Kudura, Sandra N. Freiberger, Tamara Rordorf, Joanna Mangana, Ralph Braun, Reinhard Dummer

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6647-6650

Keywords: ERBB2 protein, Paget disease, extramammary, trastuzumab, lapatinib

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Nicci Owusu-Brackett, Kurt W. Evans, Argun Akcakanat, Erkan Yuca, Coya Tapia, Yasmeen Qamar Rizvi, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5011-5019

Keywords: breast cancer, TAK228, PI3K, PTEN, TNBC

GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer Research Paper

Avaniyapuram Kannan Murugan, Ebtesam Qasem, Hindi Al-Hindi, Ali S. Alzahrani

Published Jun 25, 2019 · Vol. 10, No. 41 · pp. 4107-4124

Keywords: thyroid cancer, mutations, PTEN, oncogene, PIK3CA

Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications Research Paper

Maria-Magdalena Georgescu, Yan Li, Mohammad Zahidul Islam, Christina Notarianni, Hai Sun, Adriana Olar, Gregory N. Fuller

Published Jun 18, 2019 · Vol. 10, No. 40 · pp. 4038-4052

Keywords: epithelioid glioblastoma, SEGA-like, mTOR, MAPK, 4E-BP1

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European Cancer and Oncology Congress

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Signaling pathway dysregulation in breast cancer Review

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

TP53 mutations determined by targeted NGS in breast cancer: a case-control study Research Paper

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Blood-based next-generation sequencing analysis of neuroendocrine neoplasms Research Paper

A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Pathogenic mutations and overall survival in 3,084 patients with cancer: the Hellenic Cooperative Oncology Group Precision Medicine Initiative Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer Research Paper

Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Signaling pathway dysregulation in breast cancer Review

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

TP53 mutations determined by targeted NGS in breast cancer: a case-control study Research Paper

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Blood-based next-generation sequencing analysis of neuroendocrine neoplasms Research Paper

A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Pathogenic mutations and overall survival in 3,084 patients with cancer: the Hellenic Cooperative Oncology Group Precision Medicine Initiative Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2S310F mutated extramammary Paget’s disease Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer Research Paper

Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper