The Oncosearch | Oncotarget

Retraction: JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer Retraction

Haifeng Qiu, Jing Li, Leslie H. Clark, Amanda L. Jackson, Lu Zhang, Hui Guo, Joshua E. Kilgore, Paola A. Gehrig, Chunxiao Zhou, Victoria L. Bae-Jump

Published Apr 24, 2026 · Vol. 17, No. 1 · pp. 206-206

Retraction: Lycium barbarum polysaccharides inhibit proliferation and migration of bladder cancer cell lines BIU87 by suppressing Pi3K/AKT pathway Retraction

Xian-Jun Zhang, Hong-Yuan Yu, Yong-Jian Cai, Mang Ke

Published Apr 24, 2026 · Vol. 17, No. 1 · pp. 193-194

Retraction: Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury Retraction

Jian-Rong Guo, Huan Wang, Xiao-Ju Jin, Dong-Lin Jia, Xun Zhou, Qiang Tao

Published Apr 17, 2026 · Vol. 17, No. 1 · pp. 187-187

Retraction: Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway Retraction

Kai Yin, Linjun Wang, Xuan Zhang, Zhongyuan He, Yiwen Xia, Jianghao Xu, Song Wei, Bowen Li, Zheng Li, Guangli Sun, Qing Li, Hao Xu, Zekuan Xu

Published Dec 17, 2025 · Vol. 16, No. 1 · pp. 878-878

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

Jassy Mary S. Lazarte, Kweku Ofosu-Asante, Syreeta L. Tilghman, Nazarius S. Lamango

Published Jul 22, 2025 · Vol. 16, No. 1 · pp. 621-641

Keywords: PCAIs, ROS, MAPK, PI3K/AKT, LTLT-Ca cells

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, Susan E. Waltz

Published Jun 16, 2025 · Vol. 16, No. 1 · pp. 508-530

Keywords: EGFR, RTKs, breast cancer, head and neck cancer, resistance mechanisms

Correction: Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression Correction

María Laura Polo, Marina Riggio, María May, María Jimena Rodríguez, María Cecilia Perrone, Melody Stallings-Mann, Diego Kaen, Marlene Frost, Matthew Goetz, Judy Boughey, Claudia Lanari, Derek Radisky, Virginia Novaro

Published May 20, 2025 · Vol. 16, No. 1 · pp. 379-381

Signaling pathway dysregulation in breast cancer Review

Dinara Ryspayeva, Attila A. Seyhan, William J. MacDonald, Connor Purcell, Tyler J. Roady, Maryam Ghandali, Nataliia Verovkina, Wafik S. El-Deiry, Martin S. Taylor, Stephanie L. Graff

Published Mar 7, 2025 · Vol. 16, No. 1 · pp. 168-201

Keywords: breast cancer, oncogenic pathways, signal dysregulation in cancer, therapeutic approaches, clinical trials

Retraction: Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses Retraction

Yinfeng Kang, Runyu Yuan, Xiaqiong Zhao, Bin Xiang, Shimin Gao, Pei Gao, Xu Dai, Minsha Feng, Yanling Li, Peng Xie, Yulian Li, Xiaoyi Gao, Tao Ren

Published Jan 20, 2025 · Vol. 16, No. 1 · pp. 10-10

Correction: FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma Correction

Jinhua Wang, Li Li, Shiwei Liu, Ying Zhao, Lin Wang, Guanhua Du

Published Jun 3, 2024 · Vol. 15, No. 1 · pp. 379-380

Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling Retraction

Kai Liu, Changcun Fang, Yuwen Shen, Zhengqin Liu, Min Zhang, Bingbing Ma, Xinyan Pang

Published Mar 27, 2024 · Vol. 15, No. 1 · pp. 402-402

Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling Retraction

Kai Liu, Changcun Fang, Yuwen Shen, Zhengqin Liu, Min Zhang, Bingbing Ma, Xinyan Pang

Published Mar 27, 2024

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

Mark Lee, Luc GT Morris

Published Dec 15, 2023 · Vol. 15, No. 1 · pp. 36-48

Keywords: thyroid cancer, drug resistance, anaplastic transformation, BRAF inhibitors, PIK3CA

Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells Research Paper

Astha Lamichhane, Gary D. Luker, Seema Agarwal, Hossein Tavana

Published Sep 25, 2023 · Vol. 14, No. 1 · pp. 879-889

Keywords: drug resistance, cancer stem cells, patient-derived tumor model, colorectal cancer, combination treatment

UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology Review

Meghan J. Price, Annee D. Nguyen, Jovita K. Byemerwa, Jasmine Flowers, César D. Baëta, C. Rory Goodwin

Published Sep 19, 2023 · Vol. 14, No. 1 · pp. 843-857

Keywords: UDP-6 glucose dehydrogenase, UGDH, cancer, oncology, cancer biology

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Fatma Alqutami, Mahmood Hachim, Charlie Hodgman, William Atiomo

Published Sep 17, 2023 · Vol. 14, No. 1 · pp. 825-835

Keywords: polycystic ovary syndrome, endometrial cancer, transcriptomics, IGF1, in-silico

Therapeutic potentials and challenges of cytostatic persister cancer cells Editorial

Paul Y. Kim, Cheuk T. Leung

Published Aug 14, 2023 · Vol. 14, No. 1 · pp. 944-945

Keywords: persister cancer cells, cytostatic therapy, cancer recurrence, PTEN/PI3K/AKT, proteasome inhibitor

ACSL4: biomarker, mediator and target in quadruple negative breast cancer Review

Marie E. Monaco

Published Jun 5, 2023 · Vol. 14, No. 1 · pp. 563-575

Keywords: ACSL4, breast cancer, ferroptosis, molecular subtype, quadruple negative breast cancer

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer Research Paper

Romana Moench, Martin Gasser, Karol Nawalaniec, Tanja Grimmig, Amrendra K. Ajay, Larissa Camila Ribeiro de Souza, Minghua Cao, Yueming Luo, Petra Hoegger, Carmen M. Ribas, Jurandir M. Ribas-Filho, Osvaldo Malafaia, Reinhard Lissner, Li-Li Hsiao, Ana Maria Waaga-Gasser

Published Oct 6, 2022 · Vol. 13, No. 1 · pp. 1140-1152

Keywords: PDGF, VEGFR, EGFR, bypassed signaling, colorectal cancer

Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors Research Paper

Andliena Tahiri, Katarina Puco, Faris Naji, Vessela N. Kristensen, Glenny Cecilie Alfsen, Lorant Farkas, Frode S. Nilsen, Stig Müller, Jan Oldenburg, Jürgen Geisler

Published Jul 8, 2022 · Vol. 13, No. 1 · pp. 970-981

Keywords: kidney cancer, kinase activity, tyrosine kinase inhibitors, renal cell carcinoma, tyrosine kinase

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Retraction: JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer Retraction

Retraction: Lycium barbarum polysaccharides inhibit proliferation and migration of bladder cancer cell lines BIU87 by suppressing Pi3K/AKT pathway Retraction

Retraction: Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury Retraction

Retraction: Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway Retraction

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression Correction

Signaling pathway dysregulation in breast cancer Review

Retraction: Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses Retraction

Correction: FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma Correction

Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling Retraction

Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling Retraction

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells Research Paper

UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology Review

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Therapeutic potentials and challenges of cytostatic persister cancer cells Editorial

ACSL4: biomarker, mediator and target in quadruple negative breast cancer Review

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer Research Paper

Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Retraction: JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer Retraction

Retraction: Lycium barbarum polysaccharides inhibit proliferation and migration of bladder cancer cell lines BIU87 by suppressing Pi3K/AKT pathway Retraction

Retraction: Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury Retraction

Retraction: Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway Retraction

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression Correction

Signaling pathway dysregulation in breast cancer Review

Retraction: Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses Retraction

Correction: FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma Correction

Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling Retraction

Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling Retraction

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells Research Paper

UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology Review

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Therapeutic potentials and challenges of cytostatic persister cancer cells Editorial

ACSL4: biomarker, mediator and target in quadruple negative breast cancer Review

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer Research Paper

Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors Research Paper