The Oncosearch | Oncotarget

A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy Case Report

Murtaza Ahmed, Brent K. Larson, Arsen Osipov, Nilofer Azad, Andrew Hendifar

Published Oct 3, 2024 · Vol. 15, No. 1 · pp. 741-747

Keywords: pancreatic cancer, immunotherapy, metastasis

Site of analysis matters - Ongoing complete response to Nivolumab in a patient with HIV/HPV related metastatic anal cancer and MLH1 mutation Research Paper

Melanie Demes, Ursula Pession, Jan Jeroch, Falko Schulze, Katrin Eichler, Daniel Martin, Peter Wild, Oliver Waidmann

Published Sep 8, 2022 · Vol. 13, No. 1 · pp. 1034-1042

Keywords: anal cancer, microsatellite instability, immunotherapy, high-throughput nucleotide sequencing, nivolumab

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

Ilyas Sahin, Andrew George, Shengliang Zhang, Kelsey E. Huntington, Zehra Ordulu, Lanlan Zhou, Wafik S. El-Deiry

Published Sep 24, 2021 · Vol. 12, No. 21 · pp. 2131-2146

Keywords: cancer immunotherapy, immune checkpoint inhibitors, hyperprogressive disease (HPD), hyperprogression (HP), humanized mouse

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

Takehiro Shiraishi, Eiji Shinto, Masato Yamadera, Ken Nagata, Hitoshi Tsuda, Satsuki Mochizuki, Yoshiki Kajiwara, Koichi Okamoto, Takahiro Einama, Yoji Kishi, Hideki Ueno

Published Oct 6, 2020 · Vol. 11, No. 43 · pp. 3807-3817

Keywords: colorectal cancer, mesothelin, endoscopic biopsy specimen, immunohistochemistry, Pathology

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells Research Paper

Nicholas J. Monteleone, Carol S. Lutz

Published May 22, 2020 · Vol. 11, No. 26 · pp. 2464-2483

Keywords: miR-708-5p, miR-708, lung cancer, COX-2, mPGES-1

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? – Somatic mutational profiles vs. ovarian and colorectal carcinomas Research Paper

Noora K. Porkka, Alisa Olkinuora, Teijo Kuopio, Maarit Ahtiainen, Samuli Eldfors, Henrikki Almusa, Jukka-Pekka Mecklin, Päivi Peltomäki

Published Apr 7, 2020 · Vol. 11, No. 14 · pp. 1244-1256

Keywords: Lynch syndrome, breast carcinoma, MSI, DNA mismatch repair, somatic mutation

MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric inflammation and cancer development: critical importance of miR-155 Research Perspective

Christian Prinz, David Weber

Published Mar 10, 2020 · Vol. 11, No. 10 · pp. 894-904

Keywords: Helicobacter pylori, gastric inflammation, gastric cancer, microRNA, miR-155

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Richard K. Yang, Yun Qing, Fatima Zahra Jelloul, Mark J. Routbort, Peng Wang, Kenna Shaw, Jiexin Zhang, Jack Lee, L. Jeffrey Medeiros, Scott Kopetz, Michael T. Tetzlaff, Russell R. Broaddus

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 600-618

Keywords: biomarkers, immunotherapy, mutations, TMB, histology

Prognostic value of a three-scale grading system based on combining molecular imaging with ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper

Ioannis Karfis, Gwennaëlle Marin, Hugo Levillain, Stylianos Drisis, Raoul Muteganya, Gabriela Critchi, Loubna Taraji-Schiltz, Carlos Artigas Guix, Leila Shaza, Meriem Elbachiri, Laura Mans, Godelieve Machiels, Alain Hendlisz, Patrick Flamen

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 589-599

Keywords: gastroenteropancreatic neuroendocrine neoplasias, molecular imaging, prognostic biomarkers, ⁶⁸Ga-DOTATATE PET/CT, ¹⁸F-FDG PET/CT

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Antonio Marchetti, Alessia Di Lorito, Lara Felicioni, Fiamma Buttitta

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6957-6968

Keywords: tumor-agnostic treatments, microsatellite instability (MSI), neurotrophic receptor tyrosine kinase (NRTK), tissue microarrays (TMAs), tissue slice arrays (TSAs)

Germline mutations in cancer-predisposition genes in patients with biliary tract cancer Research Paper

Takeshi Terashima, Kumiko Umemoto, Hideaki Takahashi, Hiroko Hosoi, Erina Takai, Shunsuke Kondo, Yasunari Sakamoto, Shuichi Mitsunaga, Izumi Ohno, Yusuke Hashimoto, Mitsuhito Sasaki, Masafumi Ikeda, Kazuaki Shimada, Shuichi Kaneko, Shinichi Yachida, Kokichi Sugano, Takuji Okusaka, Chigusa Morizane

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5949-5957

Keywords: germline mutations, biliary tract cancer, hereditary breast cancer syndrome, hereditary ovarian cancer syndrome, cancer-predisposition genes

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Esmee Koedoot, Liesanne Wolters, Bob van de Water, Sylvia E. Le Dévédec

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 6021-6037

Keywords: hallmarks of cancer, breast cancer, alternative splicing, splice factors, RNA sequencing

Driver genes exome sequencing reveals distinct variants in African Americans with colorectal neoplasia Research Paper

Hassan Ashktorab, Hamed Azimi, Sudhir Varma, Edward L. Lee, Adeyinka O. Laiyemo, Michael L. Nickerson, Hassan Brim

Published Apr 5, 2019 · Vol. 10, No. 27 · pp. 2607-2624

Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells Research Paper

Tadayoshi Yamaura, Hiroyuki Miyoshi, Hisatsugu Maekawa, Tomonori Morimoto, Takehito Yamamoto, Fumihiko Kakizaki, Koichiro Higasa, Kenji Kawada, Fumihiko Matsuda, Yoshiharu Sakai, M. Mark Taketo

Published Dec 25, 2018 · Vol. 9, No. 101 · pp. 37534-37548

Epithelial insulin receptor expression â€“ prognostic relevance in colorectal cancer Research Paper

Steffen M. Heckl, Marie Pellinghaus, Sandra KrÃ¼ger, Clara Bosselmann, Franziska Wilhelm, Hans-Michael Behrens, Stefan Schreiber, Christoph RÃ¶cken

Published Dec 25, 2018 · Vol. 9, No. 101 · pp. 37497-37508

Heterogeneity in the lymphocytic infiltration of deficient DNA mismatch repair colon cancers Editorial

Harry H. Yoon, Frank A. Sinicrope

Published Nov 20, 2018 · Vol. 9, No. 95 · pp. 36722-36723

Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer Research Paper

Elena Fountzilas, Vassiliki Kotoula, Ioannis Tikas, Kyriaki Manousou, Kyriaki Papadopoulou, Christos Poulios, Vasilios Karavasilis, Ioannis Efstratiou, Dimitrios Pectasides, Kleo Papaparaskeva, Ioannis Varthalitis, Christos Christodoulou, George Papatsibas, Sofia Chrisafi, Georgios K. Glantzounis, Amanda Psyrri, Gerasimos Aravantinos, Georgia-Angeliki Koliou, George K. Koukoulis, George E. Pentheroudakis, George Fountzilas

Published Nov 2, 2018 · Vol. 9, No. 86 · pp. 35623-35638

Constitutional mismatch repair-deficiency: current problems and emerging therapeutic strategies Review

Malak Abedalthagafi

Published Oct 23, 2018 · Vol. 9, No. 83 · pp. 35458-35469

Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2 Research Paper

Fumie Tanaka, Shohei Yoshimoto, Kazuhiko Okamura, Tetsuro Ikebe, Shuichi Hashimoto

Published Sep 18, 2018 · Vol. 9, No. 73 · pp. 33745-33761

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A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy Case Report

Site of analysis matters - Ongoing complete response to Nivolumab in a patient with HIV/HPV related metastatic anal cancer and MLH1 mutation Research Paper

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells Research Paper

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? – Somatic mutational profiles vs. ovarian and colorectal carcinomas Research Paper

MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric inflammation and cancer development: critical importance of miR-155 Research Perspective

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Prognostic value of a three-scale grading system based on combining molecular imaging with ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Germline mutations in cancer-predisposition genes in patients with biliary tract cancer Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Driver genes exome sequencing reveals distinct variants in African Americans with colorectal neoplasia Research Paper

Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells Research Paper

Epithelial insulin receptor expression â€“ prognostic relevance in colorectal cancer Research Paper

Heterogeneity in the lymphocytic infiltration of deficient DNA mismatch repair colon cancers Editorial

Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer Research Paper

Constitutional mismatch repair-deficiency: current problems and emerging therapeutic strategies Review

Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2 Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy Case Report

Site of analysis matters - Ongoing complete response to Nivolumab in a patient with HIV/HPV related metastatic anal cancer and MLH1 mutation Research Paper

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells Research Paper

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? – Somatic mutational profiles vs. ovarian and colorectal carcinomas Research Paper

MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric inflammation and cancer development: critical importance of miR-155 Research Perspective

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Prognostic value of a three-scale grading system based on combining molecular imaging with 68Ga-DOTATATE and 18F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Germline mutations in cancer-predisposition genes in patients with biliary tract cancer Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Driver genes exome sequencing reveals distinct variants in African Americans with colorectal neoplasia Research Paper

Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells Research Paper

Epithelial insulin receptor expression â€“ prognostic relevance in colorectal cancer Research Paper

Heterogeneity in the lymphocytic infiltration of deficient DNA mismatch repair colon cancers Editorial

Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer Research Paper

Constitutional mismatch repair-deficiency: current problems and emerging therapeutic strategies Review

Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2 Research Paper

Prognostic value of a three-scale grading system based on combining molecular imaging with ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper