The Oncosearch | Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, Susan E. Waltz

Published Jun 16, 2025 · Vol. 16, No. 1 · pp. 508-530

Keywords: EGFR, RTKs, breast cancer, head and neck cancer, resistance mechanisms

Correction: Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Correction

Gaurav S. Choudhary, Trinh T. Tat, Saurav Misra, Brian T. Hill, Mitchell R. Smith, Alexandru Almasan, Suparna Mazumder

Published Jun 11, 2024 · Vol. 15, No. 1 · pp. 468-469

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Lulzim Shkreta, Johanne Toutant, Aurélie Delannoy, David Durantel, Anna Salvetti, Sophie Ehresmann, Martin Sauvageau, Julien A. Delbrouck, Alice Gravel-Trudeau, Christian Comeau, Caroline Huard, Jasmin Coulombe-Huntington, Mike Tyers, David Grierson, Pierre-Luc Boudreault, Benoit Chabot

Published May 9, 2024 · Vol. 15, No. 1 · pp. 313-325

Keywords: CLK kinases inhibitors, EMT, antiviral immune response, microtubules, metastasis

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

Michael R. Booth, Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 124-133

Keywords: autophagy, ER stress, GZ17-6.02, bexarotene, vorinostat

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

Fusheng Zhou, Lili Tang, Siyuan Le, Mei Ge, Dragan Cicic, Fubo Xie, Jinmin Ren, Jiong Lan, Qiang Lu

Published Dec 9, 2023 · Vol. 14, No. 1 · pp. 997-1008

Keywords: GFH009, CDK9, cancer, leukemia, cell cycle

CDK9 INHIBITORS: a promising combination partner in the treatment of hematological malignancies Research Perspective

Daniel Morillo, Gala Vega, Victor Moreno

Published Jun 29, 2023 · Vol. 14, No. 1 · pp. 749-752

Keywords: cyclin-dependent kinases (CDK), CDK9, hematological malignancies

Deciphering the mechanisms of action of progesterone in breast cancer Research Perspective

Gaurav Chakravorty, Suhail Ahmad, Mukul S. Godbole, Sudeep Gupta, Rajendra A. Badwe, Amit Dutt

Published Jun 5, 2023 · Vol. 14, No. 1 · pp. 660-667

Keywords: breast cancer, progesterone, DSCAM-AS1, endocrine therapy

Therapy drives genomic evolution in metastatic cancer Editorial

Ditte S. Christensen, Nicolai J. Birkbak

Published Mar 2, 2023 · Vol. 14, No. 1 · pp. 216-218

Keywords: cancer evolution, metastatic cancer mutations, treatment-induced mutations, GENIE

The role of Kras and canonical Wnt pathways for tumorigenesis of extrahepatic biliary system Editorial

Munemasa Nagao, Akihisa Fukuda, Hiroshi Seno

Published Jan 17, 2023 · Vol. 14, No. 1 · pp. 54-56

Keywords: ICPN, BilIN, biliary cancer, Kras, Wnt

Correction: MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Correction

David King, Xiao Dun Li, Gilberto S. Almeida, Colin Kwok, Polly Gravells, Daniel Harrison, Saoirse Burke, Albert Hallsworth, Yann Jamin, Sally George, Simon P. Robinson, Christopher J. Lord, Evon Poon, Daniel Yeomanson, Louis Chesler, Helen E. Bryant

Published Dec 20, 2022 · Vol. 14, No. 1 · pp. 21-22

Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD) Research Paper

Mamoun Younes, Lin Zhang, Baharan Fekry, Kristin Eckel-Mahan

Published Nov 26, 2022 · Vol. 13, No. 1 · pp. 1308-1313

Keywords: hepatocyte nuclear factor four alpha, steatohepatitis, immunohistochemistry, hepatocellular carcinoma, isoform

Genomic alterations predictive of poor clinical outcomes in pan-cancer Research Paper

Crystal S. Seldon, Karthik Meiyappan, Hannah Hoffman, Jimmy A. Guo, Neha Goel, William L. Hwang, Paul L. Nguyen, Brandon A. Mahal, Mohammed Alshalalfa

Published Sep 20, 2022 · Vol. 13, No. 1 · pp. 1069-1077

Keywords: genomic alterations, TP53, TCGA, poor prognosis

A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis Research Paper

Arvand Asghari, Katherine Wall, Michael Gill, Natascha Del Vecchio, Farnaz Allahbakhsh, Jacky Wu, Nan Deng, W. Jim Zheng, Hulin Wu, Michihisa Umetani, Vahed Maroufy

Published Mar 29, 2022 · Vol. 13, No. 1 · pp. 600-613

Keywords: breast cancer, triple negative breast cancer, gene expression profiling, endocrine resistance, gene clustering

Correction: PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation Correction

Weiwei Yang, Xue Wang, Jia Liu, Chunli Duan, Ge Gao, Lingling Lu, Shun Yu, Hui Yang

Published Mar 8, 2022

Transplantation of autologous bone marrow pre-loaded ex vivo with oncolytic myxoma virus is efficacious against drug-resistant Vk*MYC mouse myeloma Research Paper

Nancy Y. Villa, Masmudur M. Rahman, Joseph Mamola, Meaghen E. Sharik, Ana Lemos de Matos, Jacquelyn Kilbourne, Kenneth Lowe, Juliane Daggett-Vondras, Julia D'Isabella, Elizabeth Goras, Marta Chesi, P. Leif Bergsagel, Grant McFadden

Published Feb 21, 2022 · Vol. 13, No. 1 · pp. 490-504

Keywords: myxoma virus, multiple myeloma, combination therapy, autologous transplantation, oncolytic virus

Correction: HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation Correction

Yue-Mei Xu, Hong-Jiang Wang, Fang Chen, Wan-Hua Guo, Yan-Yang Wang, Hang-Yu Li, Jin-Hai Tang, Ying Ding, Ya-Chen Shen, Min Li, Wen-Ying Xuan, Lin-Hui Liu, Jia Wang, Xue-Rong Wang, Ze-Jun Gao, Xiu-Bin Liang, Dong-Ming Su

Published Jan 25, 2022

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma Research Paper

Rachael A. Clark, Jingbo Qiao, Jillian C. Jacobson, Dai H. Chung

Published Dec 22, 2021 · Vol. 13, No. 1 · pp. 32-45

Keywords: neuroblastoma, serine hydroxymethyltransferase 2 (SHMT2), tumorigenesis, serine metabolism, one-carbon metabolism

RASAL2 suppresses the proliferative and invasive ability of PC3 prostate cancer cells Research Paper

Krishma Tailor, Joseph Paul, Somiranjan Ghosh, Namita Kumari, Bernard Kwabi-Addo

Published Dec 15, 2021 · Vol. 12, No. 26 · pp. 2489-2499

Keywords: RASAL2, Ras-protooncogene, prostate cancer, TNFα signal, DNA methylation

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

Monica Sharma, Isabel Castro-Piedras, Fahmida Rasha, Sabarish Ramachandran, Souad R. Sennoune, Kathryn Furr, Sharilyn Almodovar, Vadivel Ganapathy, Matthew B. Grisham, Rakhshanda Layeequr Rahman, Kevin Pruitt

Published Sep 28, 2021 · Vol. 12, No. 22 · pp. 2234-2251

Keywords: dishevelled (DVL), post-translational modification, lysine residue, gene expression, chromatin immunoprecipitation (ChIP)

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase Priority Research Paper

Shuai Zhao, Wafik S. El-Deiry

Published Sep 15, 2021 · Vol. 12, No. 20 · pp. 1970-1979

Keywords: Smurf2, CDK4/6 inhibition, HIF1alpha, hypoxia, cancer therapy

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Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Correction

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

CDK9 INHIBITORS: a promising combination partner in the treatment of hematological malignancies Research Perspective

Deciphering the mechanisms of action of progesterone in breast cancer Research Perspective

Therapy drives genomic evolution in metastatic cancer Editorial

The role of Kras and canonical Wnt pathways for tumorigenesis of extrahepatic biliary system Editorial

Correction: MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Correction

Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD) Research Paper

Genomic alterations predictive of poor clinical outcomes in pan-cancer Research Paper

A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis Research Paper

Correction: PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation Correction

Transplantation of autologous bone marrow pre-loaded ex vivo with oncolytic myxoma virus is efficacious against drug-resistant Vk*MYC mouse myeloma Research Paper

Correction: HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation Correction

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma Research Paper

RASAL2 suppresses the proliferative and invasive ability of PC3 prostate cancer cells Research Paper

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase Priority Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Correction

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

CDK9 INHIBITORS: a promising combination partner in the treatment of hematological malignancies Research Perspective

Deciphering the mechanisms of action of progesterone in breast cancer Research Perspective

Therapy drives genomic evolution in metastatic cancer Editorial

The role of Kras and canonical Wnt pathways for tumorigenesis of extrahepatic biliary system Editorial

Correction: MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Correction

Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD) Research Paper

Genomic alterations predictive of poor clinical outcomes in pan-cancer Research Paper

A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis Research Paper

Correction: PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation Correction

Transplantation of autologous bone marrow pre-loaded ex vivo with oncolytic myxoma virus is efficacious against drug-resistant Vk*MYC mouse myeloma Research Paper

Correction: HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation Correction

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma Research Paper

RASAL2 suppresses the proliferative and invasive ability of PC3 prostate cancer cells Research Paper

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase Priority Research Paper