The Oncosearch | Oncotarget

Inhibitory effects of Tomivosertib in acute myeloid leukemia Research Paper

Milagros Suarez, Gavin T. Blyth, Alain A. Mina, Ewa M. Kosciuczuk, Blazej Dolniak, Shira Dinner, Jessica K. Altman, Elizabeth A. Eklund, Diana Saleiro, Elspeth M. Beauchamp, Leonidas C. Platanias

Published Apr 24, 2021 · Vol. 12, No. 10 · pp. 955-966

Keywords: MNK, Tomivosertib, acute myeloid leukemia, eIF4E

IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer Research Paper

Mahasin A. Osman, William James Antonisamy, Evgeny Yakirevich

Published May 24, 2020 · Vol. 11, No. 26 · pp. 2493-2511

Keywords: IQGAP1, BRCA1, β-catenin, MNK1, triple negative breast cancer

Inhibitory effects of SEL201 in acute myeloid leukemia Research Paper

Ewa M. Kosciuczuk, Aroop K. Kar, Gavin T. Blyth, Mariafausta Fischietti, Sameem Abedin, Alain A. Mina, Rebekah Siliezar, Tomasz Rzymski, Krzysztof Brzozka, Elizabeth A. Eklund, Elspeth M. Beauchamp, Frank Eckerdt, Diana Saleiro, Leonidas C. Platanias

Published Dec 24, 2019 · Vol. 10, No. 67 · pp. 7112-7121

Keywords: acute myeloid leukemia, MNK, eIF4E, kinase inhibitor, SEL201

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

Osamu Ichiyanagi, Hiromi Ito, Sei Naito, Takanobu Kabasawa, Hidenori Kanno, Takafumi Narisawa, Masaki Ushijima, Yuta Kurota, Michinobu Ozawa, Toshihiko Sakurai, Hayato Nishida, Tomoyuki Kato, Mitsunori Yamakawa, Norihiko Tsuchiya

Published Jun 18, 2019 · Vol. 10, No. 40 · pp. 4053-4068

Keywords: renal cell carcinoma, phospho-eIF4E (p-eIF4E), MNK (MAPK-interacting kinase), recurrence-free, epithelial−mesenchymal transition

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells Research Paper

Ella Lineham, Graham J. Tizzard, Simon J. Coles, John Spencer, Simon J. Morley

Published Mar 6, 2018 · Vol. 9, No. 18 · pp. 14148-14159

Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer Research Paper

Celia Pinto-DÃez, Eva M. GarcÃa-Recio, M. Isabel PÃ©rez-Morgado, Marta GarcÃa-HernÃ¡ndez, Lara Sanz-Criado, Silvia SacristÃ¡n, M. Val Toledo-Lobo, BelÃ©n PÃ©rez-Mies, Isabel Esteban-RodrÃguez, Alejandro Pascual, Mercedes Garcia-Villanueva, Noelia MartÃnez-JaÃ±ez, VÃctor M. GonzÃ¡lez, M. Elena MartÃn

Published Feb 5, 2018 · Vol. 9, No. 17 · pp. 13501-13516

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1 Research Paper

Shuye Tian, Xuemin Wang, Christopher G. Proud

Published May 2, 2017 · Vol. 8, No. 28 · pp. 46121-46135

miR-551b regulates epithelial-mesenchymal transition and metastasis of gastric cancer by inhibiting ERBB4 expression Research Paper

Guangyuan Song, Hongcheng Zhang, Chenlin Chen, Lijie Gong, Biao Chen, Shaoyun Zhao, Ji Shi, Ji Xu, Zaiyuan Ye

Published Apr 24, 2017 · Vol. 8, No. 28 · pp. 45725-45735

Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice Research Paper

Andrew K. Kwegyir-Afful, Francis N. Murigi, Puranik Purushottamachar, Vidya P. Ramamurthy, Marlena S. Martin, Vincent C.O. Njar

Published Dec 24, 2016 · Vol. 8, No. 32 · pp. 52381-52402

Inhibiting the MNK-eIF4E-Î²-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy Research Paper

Zhiqiang Li, Yang Sun, Miao Qu, Hongxing Wan, Fang Cai, Peng Zhang

Published Dec 1, 2016 · Vol. 8, No. 2 · pp. 2906-2915

PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-α expression levels Research Paper

Yabing Zheng, Gang Zhao, Bing Xu, Chunyan Liu, Chang Li, Xiaoqian Zhang, Xiaotian Chang

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 62159-62176

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells Research Paper

Peng Li, Sarah Diab, Mingfeng Yu, Julian Adams, Saiful Islam, Sunita K.C. Basnet, Hugo Albrecht, Robert Milne, Shudong Wang

Published Jul 23, 2016 · Vol. 7, No. 35 · pp. 56811-56825

CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway Research Paper

Qiuyuan Wen, Weiyuan Wang, Jiadi Luo, Shuzhou Chu, Lingjiao Chen, Lina Xu, Hongjing Zang, Mohannad Ma Alnemah, Jian Ma, Songqing Fan

Published Mar 30, 2016 · Vol. 7, No. 19 · pp. 27787-27801

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines Research Paper

Vidya P. Ramamurthy, Senthilmurugan Ramalingam, Lalji Gediya, Andrew K. Kwegyir-Afful, Vincent C.O. Njar

Published Dec 26, 2014 · Vol. 6, No. 5 · pp. 3195-3210

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Frank Eckerdt, Elspeth Beauchamp, Jonathan Bell, Asneha Iqbal, Bing Su, Rikiro Fukunaga, Rishi R. Lulla, Stewart Goldman, Leonidas C. Platanias

Published Aug 6, 2014 · Vol. 5, No. 18 · pp. 8442-8451

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73 Research Paper

Frankie Lam, Abdullahi Y. Abbas, Hao Shao, Theodosia Teo, Julian Adams, Peng Li, Tracey D. Bradshaw, Peter M. Fischer, Elisabeth Walsby, Chris Pepper, Yi Chen, Jian Ding, Shudong Wang

Published Jul 31, 2014 · Vol. 5, No. 17 · pp. 7691-7704

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Senthilmurugan Ramalingam, Lalji Gediya, Andrew K. Kwegyir-Afful, Vidya P. Ramamurthy, Puranik Purushottamachar, Hannah Mbatia, Vincent C.O. Njar

Published Jan 25, 2014 · Vol. 5, No. 2 · pp. 530-543

Keywords: Breast cancer, RAMBA retinamides, eukaryotic initiation factor 4E, Mnk1/2

Targeting Mnks for Cancer Therapy Review

Jinqiang Hou, Frankie Kam, Christopher G Proud, Shudong Wang

Published Mar 3, 2012 · Vol. 3, No. 2 · pp. 118-131

Keywords: eIF4E, Mnk, Ras, Raf, MAPK, Akt, PI3K, mTOR, Targeted Cancer Therapy, Structure based drug design, Mnk Inhibitors

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Inhibitory effects of Tomivosertib in acute myeloid leukemia Research Paper

IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer Research Paper

Inhibitory effects of SEL201 in acute myeloid leukemia Research Paper

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells Research Paper

Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer Research Paper

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1 Research Paper

miR-551b regulates epithelial-mesenchymal transition and metastasis of gastric cancer by inhibiting ERBB4 expression Research Paper

Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice Research Paper

Inhibiting the MNK-eIF4E-Î²-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy Research Paper

PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-α expression levels Research Paper

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells Research Paper

CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway Research Paper

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines Research Paper

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73 Research Paper

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Targeting Mnks for Cancer Therapy Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Inhibitory effects of Tomivosertib in acute myeloid leukemia Research Paper

IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer Research Paper

Inhibitory effects of SEL201 in acute myeloid leukemia Research Paper

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells Research Paper

Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer Research Paper

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1 Research Paper

miR-551b regulates epithelial-mesenchymal transition and metastasis of gastric cancer by inhibiting ERBB4 expression Research Paper

Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice Research Paper

Inhibiting the MNK-eIF4E-Î²-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy Research Paper

PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-α expression levels Research Paper

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells Research Paper

CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway Research Paper

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines Research Paper

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73 Research Paper

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Targeting Mnks for Cancer Therapy Review