The Oncosearch | Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, Susan E. Waltz

Published Jun 16, 2025 · Vol. 16, No. 1 · pp. 508-530

Keywords: EGFR, RTKs, breast cancer, head and neck cancer, resistance mechanisms

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Yan Luo, Lei Liu, Yang Wu, Karnika Singh, Bing Su, Nan Zhang, Xiaowei Liu, Yangmei Shen, Shile Huang

Published Jun 10, 2025 · Vol. 16, No. 1 · pp. 425-426

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang, Qian Li

Published Mar 13, 2025 · Vol. 16, No. 1 · pp. 167-167

Retraction: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma Retraction

Chuanzong Zhao, Qian Wang, Ben Wang, Qi Sun, Zhaobin He, Jianguo Hong, Florian Kuehn, Enyu Liu, Zongli Zhang

Published Mar 27, 2024 · Vol. 15, No. 1 · pp. 549-549

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Fatma Alqutami, Mahmood Hachim, Charlie Hodgman, William Atiomo

Published Sep 17, 2023 · Vol. 14, No. 1 · pp. 825-835

Keywords: polycystic ovary syndrome, endometrial cancer, transcriptomics, IGF1, in-silico

Retraction: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer Retraction

Hong Wang, Chunlei Wang, Wenling Tian, Yanfen Yao

Published May 10, 2023 · Vol. 15, No. 1 · pp. 573-573

Correction: IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Correction

Rehanna Mansor, Jeff Holly, Rachel Barker, Kalina Biernacka, Hanna Zielinska, Anthony Koupparis, Edward Rowe, Jon Oxley, Alex Sewell, Richard M. Martin, Athene Lane, Lucy Hackshaw-McGeagh, Claire Perks

Published Jan 7, 2023 · Vol. 14, No. 1 · pp. 44-46

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang, Qian Li

Published Dec 14, 2022

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Alice Augenlicht, Manuel Saiselet, Myriam Decaussin-Petrucci, Guy Andry, Jacques E. Dumont, Carine Maenhaut

Published Jul 17, 2021 · Vol. 12, No. 16 · pp. 1587-1599

Keywords: miRNA, papillary thyroid carcinoma, IRS2, MAPK, PI3K

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

Yehia I. Mohamed, Sunyoung Lee, Lianchun Xiao, Manal M. Hassan, Aliya Qayyum, Rikita Hiatia, Roberto Carmagnani Pestana, Abedul Haque, Bhawana George, Asif Rashid, Dan G. Duda, Hesham Elghazaly, Robert A. Wolff, Jeffrey S. Morris, James Yao, Hesham M. Amin, Ahmed O. Kaseb

Published Mar 13, 2021 · Vol. 12, No. 8 · pp. 756-766

Keywords: IGF-1, Child-Pugh, sorafenib, liver reserve, hepatocellular carcinoma

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Jackie Bader, Meredith Carson, Reilly Enos, Kandy Velazquez, Alexander Sougiannis, Udai Singh, William Becker, Mitzi Nagarkatti, Daping Fan, Angela Murphy

Published Nov 24, 2020 · Vol. 11, No. 49 · pp. 4554-4569

Keywords: colorectal cancer, obesity, metabolism, macrophage, inflammation

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Rehanna Mansor, Jeff Holly, Rachel Barker, Kalina Biernacka, Hanna Zielinska, Anthony Koupparis, Edward Rowe, Jon Oxley, Alex Sewell, Richard M. Martin, Athene Lane, Lucy Hackshaw-McGeagh, Claire Perks

Published Jun 11, 2020 · Vol. 11, No. 26 · pp. 2543-2559

Keywords: hyperglycaemia, prostate cancer, FOXA1, IGFBP-2, EMT

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Rive Sarfstein, Haim Werner

Published Jun 9, 2020 · Vol. 11, No. 25 · pp. 2424-2437

Keywords: insulin, insulin-like growth factor-1 (IGF1), insulin receptor, IGF1 receptor, p53

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Mai Ahmed Shafei, Thomas Forshaw, Jasmine Davis, Arwa Flemban, David Qualtrough, Sarah Dean, Claire Perks, Ming Dong, Robert Newman, Myra Elizabeth Conway

Published May 8, 2020 · Vol. 11, No. 21 · pp. 1971-1987

Keywords: BCAT, PI3K-AKT, ERK, breast cancer

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

Tali Sinai-Livne, Metsada Pasmanik-Chor, Zoya Cohen, Ilan Tsarfaty, Haim Werner, Raanan Berger

Published Apr 13, 2020 · Vol. 11, No. 17 · pp. 1515-1530

Keywords: insulin-like growth factor-1 (IGF1), IGF1 receptor (IGF1R), targeted therapy, breast cancer, proteomic analysis

A phase II randomized clinical trial using aglycone isoflavones to treat patients with localized prostate cancer in the pre-surgical period prior to radical prostatectomy Research Paper

Nagi B. Kumar, Julio Pow-Sang, Philippe Spiess, Shohreh Dickinson, Michael J. Schell

Published Apr 7, 2020 · Vol. 11, No. 14 · pp. 1218-1234

Keywords: isoflavones, chemoprevention, prostate cancer, African American men, Caucasian men

Correction: Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway Correction

Yang Sun, Yue Zhao, Xiaoping Wang, Li Zhao, Wenjun Li, Youxiang Ding, Lingyi Kong, Qinglong Guo, Na Lu

Published Dec 3, 2019

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer Research Paper

Laris Achlaug, Rive Sarfstein, Karthik Nagaraj, Lena Lapkina-Gendler, Ilan Bruchim, Manisha Dixit, Zvi Laron, Shoshana Yakar, Haim Werner

Published Jul 9, 2019 · Vol. 10, No. 43 · pp. 4437-4448

Keywords: insulin-like growth factor-1 (IGF1), IGF1 receptor, ZYG11A, p53, endometrial cancer

Correction: Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Correction

Junjie Gao, Tak Sum Cheng, An Qin, Nathan J. Pavlos, Tao Wang, Kai Song, Yan Wang, Lianzhi Chen, Lin Zhou, Qing Jiang, Hiroshi Takayanagi, Sheng Yan, Minghao Zheng

Published Jun 12, 2019 · Vol. 10, No. 40 · pp. 4079-4079

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Shan-Ju Yeh, Chien-An Chang, Cheng-Wei Li, Lily Hui-Ching Wang, Bor-Sen Chen

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3760-3806

Keywords: lung adenocarcinoma, lung squamous cell carcinoma, NSCLC, genetic and epigenetic network, potential drug target

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Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Retraction: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma Retraction

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Retraction: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer Retraction

Correction: IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

A phase II randomized clinical trial using aglycone isoflavones to treat patients with localized prostate cancer in the pre-surgical period prior to radical prostatectomy Research Paper

Correction: Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway Correction

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer Research Paper

Correction: Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Correction

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Retraction: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma Retraction

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Retraction: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer Retraction

Correction: IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

A phase II randomized clinical trial using aglycone isoflavones to treat patients with localized prostate cancer in the pre-surgical period prior to radical prostatectomy Research Paper

Correction: Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway Correction

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer Research Paper

Correction: Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Correction

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper