The Oncosearch | Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Tayo A. Adeyika, Anju Datturgi, Yehnara Ettinoffe, Somiranjan Ghosh, Christopher Albanese, Bernard Kwabi-Addo

Published Apr 1, 2026 · Vol. 17, No. 1 · pp. 157-172

Keywords: PDX1, DNA methylation prostate cancer, shRNA knockdown, over-expression, glucose

LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas Research Paper

Marlene Happe, Saskia Kuhl, Lukas Görtz, Roland Goldbrunner, Marco Timmer

Published Oct 27, 2025 · Vol. 16, No. 1 · pp. 793-807

Keywords: glioma, glioblastoma, LRIG1, LRIG2, LRIG3

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Valeriy Domenyuk, Kasey Benson, Peggy Carter, Daniel Magee, Jian Zhang, Nitin Bhardwaj, Hongseok Tae, James Wacker, Foram Rathi, Siobhan Miick, Aastha Kohli, Joshua Carroll, Lori Cuyugan, Evelyn Perez, Wayeesha Zhang, John Collins, Patrick Kennedy, Jeremy Ellis, Adam Stark, Andrey Loskutov, Brittany Cuttone, Blake Taylor, Rebecca Feldman, Jeff Swenson, David Bryant, Robert Hahn-Lowry, Raunaq Kaushal, Jennifer R. Ribeiro, Jim Abraham, Milan Radovich, George W. Sledge, Matthew Oberley, David Spetzler

Published Aug 6, 2025 · Vol. 16, No. 1 · pp. 642-659

Keywords: companion diagnostic, molecular profiling, solid tumors, precision oncology, next-generation sequencing

Comprehensive genomic profiling of over 10,000 advanced solid tumors Research Paper

Jean-Paul De La O, Jess R. Hoag, Angela K. Deem, Min Wang, Arthur Starodynov, Sameer S. Udhane, Janine R. LoBello, Nishitha Therala, David W. Hall, Gargi D. Basu, Frederick L. Baehner

Published Jul 19, 2025 · Vol. 16, No. 1 · pp. 587-603

Keywords: solid tumors, comprehensive genomic profiling, matched therapy, gene fusions, limit of detection

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Helen Qian, Heba Ali, Vivekanudeep Karri, Justin T. Low, David M. Ashley, Amy B. Heimberger, Lucy A. Godley, Adam M. Sonabend, Crismita Dmello

Published Jun 5, 2025 · Vol. 16, No. 1 · pp. 445-453

Keywords: CHEK2, immune checkpoint inhibitors, immunomodulation

Immune-mediated adverse events following atezolizumab and bevacizumab in a multinational Latin American cohort of unresectable hepatocellular carcinoma Research Paper

Leonardo Gomes da Fonseca, Federico Piñero, Margarita Anders, Carla Bermudez, Ezequiel Demirdjian, Adriana Varón, Daniela Perez, Jorge Rodriguez, Oscar Beltrán, Ezequiel Ridruejo, Pablo Caballini, Alexandre Araujo, Juan Diego Torres Florez, Juan Ignacio Marín, Marina Villa, Federico Orozco, Jaime Poniachik, Sebastián Marciano, Fernando Bessone, Manuel Mendizabal

Published May 8, 2025 · Vol. 16, No. 1 · pp. 348-360

Keywords: liver cancer, immunotherapy, adverse events, immunology, real-world

PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region Research Paper

Humberto Carvalho Carneiro, Rodrigo de Andrade Natal, José Vassallo, Fernando Augusto Soares

Published Apr 21, 2025 · Vol. 16, No. 1 · pp. 277-290

Keywords: HPV, high-grade intraepithelial lesion, immune evasion, PD-L1, FOXP3

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Lanlan Zhou, Leiqing Zhang, Jun Zhang, Laura Jinxuan Wu, Shengliang Zhang, Andrew George, Marina Hahn, Howard P. Safran, Clark C. Chen, Attila A. Seyhan, Eric T. Wong, Wafik S. El-Deiry

Published Mar 20, 2025 · Vol. 16, No. 1 · pp. 230-248

Keywords: glioblastoma multiforme, IDH, ONC201, ONC206, MGMT, temozolomide, radiotherapy

Signaling pathway dysregulation in breast cancer Review

Dinara Ryspayeva, Attila A. Seyhan, William J. MacDonald, Connor Purcell, Tyler J. Roady, Maryam Ghandali, Nataliia Verovkina, Wafik S. El-Deiry, Martin S. Taylor, Stephanie L. Graff

Published Mar 7, 2025 · Vol. 16, No. 1 · pp. 168-201

Keywords: breast cancer, oncogenic pathways, signal dysregulation in cancer, therapeutic approaches, clinical trials

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Whitney L. Hensing, Emily L. Podany, James J. Sears, Shaili Tapiavala, Andrew A. Davis

Published Jan 9, 2025 · Vol. 16, No. 1 · pp. 11-27

Keywords: breast cancer, HER2-low, genomics

Correction: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation Correction

Christophe Le Clorennec, Yassamine Lazrek, Olivier Dubreuil, Christel Larbouret, Marie-Alix Poul, Philippe Mondon, Gerry Melino, André Pèlegrin, Thierry Chardès

Published Oct 11, 2024 · Vol. 15, No. 1 · pp. 748-749

Initiation of tumor dormancy by the lymphovascular embolus Research Paper

Yin Ye, Justin Wang, Michael G. Izban, Billy R. Ballard, Sanford H. Barsky

Published Oct 2, 2024 · Vol. 15, No. 1 · pp. 726-740

Keywords: dormancy, lymphovascular embolus, mTOR, E-cadherin proteolysis

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, Peter M. Glazer

Published Sep 20, 2024 · Vol. 15, No. 1 · pp. 699-713

Keywords: 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Zhen Li, Mohammed A. Alshagawi, Rebecca A. Oot, Mariam K. Alamoudi, Kevin Su, Wenhui Li, Michael P. Collins, Stephan Wilkens, Michael Forgac

Published Aug 5, 2024 · Vol. 15, No. 1 · pp. 575-587

Keywords: vacuolar ATPase, breast cancer, invasion, tumor metastasis, tumor growth

Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics Research Paper

Xiaobing Tian, Wafik S. El-Deiry

Published Jul 26, 2024 · Vol. 15, No. 1 · pp. 614-633

Keywords: mutant p53, integrated stress response (ISR), ATF4, HRI, ClpP

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival Research Paper

Saif Zaman, Fred S. Gorelick, Andrea Chrobrutskiy, Boris I. Chobrutskiy, Gary V. Desir, George Blanck

Published Jul 20, 2024 · Vol. 15, No. 1 · pp. 550-561

Keywords: RNLS, melanoma, T-cell receptor CDR3s, chemical complementarity

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, Borje S. Andersson

Published May 25, 2024 · Vol. 15, No. 1 · pp. 361-373

Keywords: decitabine, HDAC inhibitors, pancreatic cancer, PARP inhibitors, synergistic cytotoxicity

Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer Research Paper

Haven R. Garber, Sreyashi Basu, Sonali Jindal, Zhong He, Khoi Chu, Akshara Singareeka Raghavendra, Clinton Yam, Lumarie Santiago, Beatriz E. Adrada, Padmanee Sharma, Elizabeth A. Mittendorf, Jennifer K. Litton

Published Mar 2, 2024 · Vol. 15, No. 1 · pp. 238-247

Keywords: breast cancer, ER positive, immunotherapy, neoadjuvant chemotherapy, tumor microenvironment

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Thomas M. Cardillo, Maria B. Zalath, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Chien-Hsing Chang, David M. Goldenberg

Published Jan 30, 2024 · Vol. 15, No. 1 · pp. 144-158

Keywords: sacituzumab govitecan, Trop-2, SN-38, carboplatin, cisplatin

Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and record linkage study from Finland Research Paper

Wei Zhang, Arndt A. Schmitz, Roosa E. Kallionpää, Merja Perälä, Niina Pitkänen, Mikko Tukiainen, Erika Alanne, Korinna Jöhrens, Renate Schulze-Rath, Bahman Farahmand, Jihong Zong

Published Jan 12, 2024 · Vol. 15, No. 1 · pp. 106-116

Keywords: NTRK gene fusion, papillary thyroid cancer, clinicogenomic, epidemiology, biobank

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Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas Research Paper

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Comprehensive genomic profiling of over 10,000 advanced solid tumors Research Paper

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Immune-mediated adverse events following atezolizumab and bevacizumab in a multinational Latin American cohort of unresectable hepatocellular carcinoma Research Paper

PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region Research Paper

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Signaling pathway dysregulation in breast cancer Review

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Correction: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation Correction

Initiation of tumor dormancy by the lymphovascular embolus Research Paper

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics Research Paper

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival Research Paper

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and record linkage study from Finland Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas Research Paper

Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper

Comprehensive genomic profiling of over 10,000 advanced solid tumors Research Paper

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Immune-mediated adverse events following atezolizumab and bevacizumab in a multinational Latin American cohort of unresectable hepatocellular carcinoma Research Paper

PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region Research Paper

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Signaling pathway dysregulation in breast cancer Review

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review

Correction: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation Correction

Initiation of tumor dormancy by the lymphovascular embolus Research Paper

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics Research Paper

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival Research Paper

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and record linkage study from Finland Research Paper

Clinical and analytical validation of MI Cancer Seek^®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper