The Oncosearch | Oncotarget

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

Noor Kazim, Wang Peng, Jianbo Yue, Andrew Yen

Published Mar 14, 2025 · Vol. 16, No. 1 · pp. 202-218

Keywords: cancer biology and cell cycle regulation, retinoic acid(RA), FGR Src-family-kinase, cancer differentiation-therapy, leukemia

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

Fusheng Zhou, Lili Tang, Siyuan Le, Mei Ge, Dragan Cicic, Fubo Xie, Jinmin Ren, Jiong Lan, Qiang Lu

Published Dec 9, 2023 · Vol. 14, No. 1 · pp. 997-1008

Keywords: GFH009, CDK9, cancer, leukemia, cell cycle

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Hirofumi Tsuzuki, Tatsuya Kawase, Taisuke Nakazawa, Masamichi Mori, Taku Yoshida

Published Dec 13, 2022 · Vol. 13, No. 1 · pp. 1359-1368

Keywords: acute myeloid leukemia (AML), ASP1235, antibody drug conjugate (ADC), venetoclax, azacitidine

Trends in oligomannosylation and α1,2-mannosidase expression in human cancers Research Paper

Sayantani Chatterjee, Julian Ugonotti, Ling Y. Lee, Arun Everest-Dass, Rebeca Kawahara, Morten Thaysen-Andersen

Published Aug 24, 2021 · Vol. 12, No. 21 · pp. 2188-2205

Keywords: oligomannose, α1,2-mannosidase, cancer, glycomics, mass spectrometry

High expression of Myosin 1g in pediatric acute lymphoblastic leukemia Research Paper

Laura A. Estrada-Abreo, Leonor Rodríguez-Cruz, Yanelly Garfias-Gómez, Janeth E. Araujo-Cardenas, Gabriela Antonio-Andrés, Alfonso R. Salgado-Aguayo, Darío Orozco-Ruiz, José Refugio Torres-Nava, Juan D. Díaz-Valencia, Sara Huerta-Yépez, Genaro Patiño-López

Published Aug 18, 2021 · Vol. 12, No. 19 · pp. 1937-1945

Keywords: Myosin 1g, acute lymphoblastic leukemia, high risk, biomarker, pediatric

Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells Research Paper

Noor Kazim, Andrew Yen

Published May 11, 2021 · Vol. 12, No. 12 · pp. 1147-1164

Keywords: retinoic acid(RA), FGR, Numb, non-APL AML, cell differentiation

Obinutuzumab (GA101) vs. rituximab significantly enhances cell death, antibody-dependent cytotoxicity and improves overall survival against CD20+ primary mediastinal B-cell lymphoma (PMBL) in a xenograft NOD-scid IL2Rgnull (NSG) mouse model: a potential targeted agent in the treatment of PMBL Research Paper

Yaya Chu, Aradhana Awasthi, Sanghoon Lee, Dina Edani, Changhong Yin, Jessica Hochberg, Tishi Shah, Tae-Hoon Chung, Janet Ayello, Carmella van de Ven, Christian Klein, Dean Lee, Mitchell S. Cairo

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3035-3047

Keywords: Obinutuzumab, rituximab, survival, primary mediastinal large B-cell lymphoma, antibody-dependent cellular cytotoxicity

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

Stefan Nagel, Claudia Pommerenke, Roderick A.F. MacLeod, Corinna Meyer, Maren Kaufmann, Hans G. Drexler

Published Jul 15, 2020 · Vol. 11, No. 34 · pp. 3208-3226

Keywords: homeobox, NKL-code, T-ALL, LL-100, Th17

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit Research Paper

Hee-Don Chae, Ritika Dutta, Bruce Tiu, Fieke W. Hoff, Benedetta Accordi, Valentina Serafin, Minyoung Youn, Min Huang, Nathan Sumarsono, Kara L. Davis, Norman J. Lacayo, Martina Pigazzi, Terzah M. Horton, Steven M. Kornblau, Kathleen M. Sakamoto

Published May 26, 2020 · Vol. 11, No. 25 · pp. 2387-2403

Keywords: acute myeloid leukemia, BI-D1870, RSK, vincristine, spindle assembly checkpoint

Phase I study of vemurafenib in children with recurrent or progressive BRAF^V600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002) Research Paper

Theodore Nicolaides, Kellie J. Nazemi, John Crawford, Lindsay Kilburn, Jane Minturn, Amar Gajjar, Karen Gauvain, Sarah Leary, Girish Dhall, Mariam Aboian, Giles Robinson, Janel Long-Boyle, Hechuan Wang, Annette M. Molinaro, Sabine Mueller, Michael Prados

Published May 5, 2020 · Vol. 11, No. 21 · pp. 1942-1952

Keywords: BRAF^V600E, pediatric glioma, vemurafenib, clinical trial

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation Research Paper

Asif Rashid, Xin Duan, Feng Gao, Mengsu Yang, Andrew Yen

Published Mar 24, 2020 · Vol. 11, No. 12 · pp. 1017-1036

Keywords: ATRA, roscovitine, APL, HL-60, Lyn

Correction: Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of p18 through claudin7 Correction

Hong Liu, Feifei Jiang, Xinshan Jia, Jing Lan, Hao Guo, Erran Li, Aihui Yan, Yan Wang

Published Dec 11, 2019 · Vol. 12, No. 19 · pp. 1966-1969

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Nikhil Gupta, Jung Eun Park, Wilford Tse, Jee Keem Low, Oi Lian Kon, Neil McCarthy, Siu Kwan Sze

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5970-5982

Keywords: pancreatic cancer, hypoxia tumor, ERO1α, SILAC, proteomics

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Jyotsna Kailashiya, Vineeta Gupta, Debabrata Dash

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5835-5846

Keywords: cancer targeting, drug-delivery vector, doxorubicin, leukemia, platelet-derived microparticles

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

El-Habib Dakir, Faustino Mollinedo

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5313-5331

Keywords: miRNA, miR-125a-5p, miR-17-92, neutrophil differentiation, human

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Piyush More, Ute Goedtel-Armbrust, Viral Shah, Marianne Mathaes, Thomas Kindler, Miguel A. Andrade-Navarro, Leszek Wojnowski

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5298-5312

Keywords: topoisomerase II poisons, DNA damage, gene expression, combination therapy, cancer essentiality

NKL homeobox gene NKX2-2 is aberrantly expressed in Hodgkin lymphoma Research Paper

Stefan Nagel, Roderick A.F. MacLeod, Claudia Pommerenke, Corinna Meyer, Maren Kaufmann, Hans G. Drexler

Published Dec 25, 2018 · Vol. 9, No. 101 · pp. 37480-37496

Predicting clinically significant prostate cancer using DCE-MRI habitat descriptors Research Paper

N. Andres Parra, Hong Lu, Qian Li, Radka Stoyanova, Alan Pollack, Sanoj Punnen, Jung Choi, Mahmoud Abdalah, Christopher Lopez, Kenneth Gage, Jong Y. Park, Yamoah Kosj, Julio M. Pow-Sang, Robert J. Gillies, Yoganand Balagurunathan

Published Dec 14, 2018 · Vol. 9, No. 98 · pp. 37125-37136

Impact of histologic subtypes and treatment modality among patients with primary central nervous system lymphoma: a SEER database analysis Research Paper

Dai Chihara, Nathan H. Fowler, Yasuhiro Oki, Michelle A. Fanale, Loretta J. Nastoupil, Jason R. Westin, Luis E. Fayad, Sattva S. Neelapu, Chan Yoon Cheah

Published Jun 22, 2018 · Vol. 9, No. 48 · pp. 28897-28902

Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib Research Paper

Rocio I.R. Macias, Anabel SÃ¡nchez-MartÃn, Gabriela RodrÃguez-MacÃas, Luis I. SÃ¡nchez-Abarca, Elisa Lozano, Elisa Herraez, Maria D. Odero, JosÃ© L. DÃez- MartÃn, Jose J.G. Marin, Oscar Briz

Published Jun 19, 2018 · Vol. 9, No. 47 · pp. 28474-28485

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FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Trends in oligomannosylation and α1,2-mannosidase expression in human cancers Research Paper

High expression of Myosin 1g in pediatric acute lymphoblastic leukemia Research Paper

Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells Research Paper

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit Research Paper

Phase I study of vemurafenib in children with recurrent or progressive BRAF^V600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002) Research Paper

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation Research Paper

Correction: Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of p18 through claudin7 Correction

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

NKL homeobox gene NKX2-2 is aberrantly expressed in Hodgkin lymphoma Research Paper

Predicting clinically significant prostate cancer using DCE-MRI habitat descriptors Research Paper

Impact of histologic subtypes and treatment modality among patients with primary central nervous system lymphoma: a SEER database analysis Research Paper

Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Trends in oligomannosylation and α1,2-mannosidase expression in human cancers Research Paper

High expression of Myosin 1g in pediatric acute lymphoblastic leukemia Research Paper

Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells Research Paper

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit Research Paper

Phase I study of vemurafenib in children with recurrent or progressive BRAFV600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002) Research Paper

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation Research Paper

Correction: Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of p18 through claudin7 Correction

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

NKL homeobox gene NKX2-2 is aberrantly expressed in Hodgkin lymphoma Research Paper

Predicting clinically significant prostate cancer using DCE-MRI habitat descriptors Research Paper

Impact of histologic subtypes and treatment modality among patients with primary central nervous system lymphoma: a SEER database analysis Research Paper

Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib Research Paper

Phase I study of vemurafenib in children with recurrent or progressive BRAF^V600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002) Research Paper