The Oncosearch | Oncotarget

Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine Research Paper

Ashley C. Dodd, Nitin R. Wadhwani, Alison Lehane, Rom Brown, Kyle L. MacQuarrie, Seth D. Goldstein, Timothy B. Lautz

Published Oct 13, 2025 · Vol. 16, No. 1 · pp. 759-767

Keywords: folate receptor, fluorescent-guided surgery, pediatric tumors, pafolacianine, RNA sequencing

Correction: YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Correction

Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Yasemin Saygideğer-Kont, Haydar Çelik, Kristina M. Mueller, Idil Temel, Metin Özdemirli, Heinrich Kovar, Hayriye Verda Erkizan, Jeffrey Toretsky, Lukas Kenner, Richard Moriggl, Aykut Üren

Published Sep 29, 2023 · Vol. 15, No. 1 · pp. 143-143

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas Research Paper

Chandni Desai, Jon Thomason, Jordan L. Kohlmeyer, Anna C. Reisetter, Parmanand Ahirwar, Khadijeh Jahanseir, Mariah Leidinger, Georgina Ofori-Amanfo, Karen Fritchie, Sadanandan E. Velu, Patrick Breheny, Dawn E. Quelle, Munir R. Tanas

Published Mar 21, 2021 · Vol. 12, No. 8 · pp. 740-755

Keywords: sarcoma, YAP, TAZ, p53-MDM2, RABL6A

KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma Research Paper

Tyler S. McCann, Janet K. Parrish, Joseph Hsieh, Marybeth Sechler, Lays M. Sobral, Chelsea Self, Kenneth L. Jones, Andrew Goodspeed, James C. Costello, Paul Jedlicka

Published Aug 29, 2020 · Vol. 11, No. 43 · pp. 3818-3831

Keywords: Ewing sarcoma, metastasis, epigenetics, Jumonji-domain histone demethylase

Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma through miR-210 delivery Research Paper

Matthew J. Kling, Nagendra K. Chaturvedi, Varun Kesherwani, Don W. Coulter, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi

Published Jul 30, 2020 · Vol. 11, No. 40 · pp. 3633-3645

Keywords: exosomes, hypoxia, Ewing’s sarcoma, stemness, miR-210

Ewing sarcoma family of tumors-derived small extracellular vesicle proteomics identify potential clinical biomarkers Research Paper

Glenson Samuel, Jennifer Crow, Jon B. Klein, Michael L. Merchant, Emily Nissen, Devin C. Koestler, Kris Laurence, Xiaobo Liang, Kathleen Neville, Vincent Staggs, Atif Ahmed, Safinur Atay, Andrew K. Godwin

Published Jul 7, 2020 · Vol. 11, No. 31 · pp. 2995-3012

Keywords: Ewing sarcoma, EWS-ETS, biomarkers, extracellular vesicles, exosomes

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma Research Paper

Priyal O. Patel, Kathleen I. Pishas, Cenny Taslim, Julia Selich-Anderson, Emily R. Theisen, Stephen L. Lessnick

Published Jun 11, 2019 · Vol. 10, No. 39 · pp. 3865-3878

Keywords: LSD2/KDM1B, Ewing sarcoma, SP-2509, LSD1/KDM1A

EWS-FLI1 low Ewing sarcoma cells demonstrate decreased susceptibility to T-cell-mediated tumor cell apoptosis Research Paper

Kelly M. Bailey, Claire M. Julian, Ariel N. Klinghoffer, Heather Bernard, Peter C. Lucas, Linda M. McAllister-Lucas

Published May 21, 2019 · Vol. 10, No. 36 · pp. 3385-3399

Keywords: EWS-FLI1, Ewing sarcoma, T-cell, interferon, apoptosis

The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth Research Paper

Janet K. Parrish, Tyler S. McCann, Marybeth Sechler, Lays M. Sobral, Wen Hua Ren, Kenneth L. Jones, Aik Choon Tan, Paul Jedlicka

Published Sep 4, 2018 · Vol. 9, No. 69 · pp. 33110-33123

The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma Research Paper

Daniel Jose GarcÃa-DomÃnguez, Lourdes Hontecillas-Prieto, Pablo RodrÃguez-NÃºÃ±ez, Guillem Pascual-Pasto, Monica Vila-Ubach, Rosa GarcÃa-MejÃas, MarÃa JosÃ© Robles, Oscar M. Tirado, Jaume Mora, Angel M. Carcaboso, Enrique de Ãlava

Published Jul 31, 2018 · Vol. 9, No. 59 · pp. 31397-31410

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers Research Paper

Kalliopi Tsafou, Anna Maria Katschnig, Branka Radic-Sarikas, Cornelia NoÃ«lle Mutz, Kristiina Iljin, Raphaela Schwentner, Maximilian O. Kauer, Karin MÃ¼hlbacher, Dave N.T. Aryee, David Westergaard, Saija Haapa-Paananen, Vidal Fey, Giulio Superti-Furga, Jeffrey Toretsky, SÃ¸ren Brunak, Heinrich Kovar

Published Jul 24, 2018 · Vol. 9, No. 57 · pp. 31018-31031

IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma Research Paper

Yu Tanabe, Yoshiyuki Suehara, Shinji Kohsaka, Takuo Hayashi, Keisuke Akaike, Kenta Mukaihara, Taisei Kurihara, Youngji Kim, Taketo Okubo, Midori Ishii, Saiko Kazuno, Kazuo Kaneko, Tsuyoshi Saito

Published Mar 6, 2018 · Vol. 9, No. 18 · pp. 14428-14443

T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G Research Paper

Christian Spurny, Sareetha Kailayangir, Bianca Altvater, Silke Jamitzky, Wolfgang Hartmann, Eva Wardelmann, Andreas Ranft, Uta Dirksen, Susanne Amler, Jendrik Hardes, Maike Fluegge, Jutta Meltzer, Nicole Farwick, Lea Greune, Claudia Rossig

Published Dec 22, 2017 · Vol. 9, No. 5 · pp. 6536-6549

EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma Research Paper

Wenjing Sun, Yesenia Rojas, Hao Wang, Yang Yu, Yongfeng Wang, Zhenghu Chen, Kimal Rajapakshe, Xin Xu, Wei Huang, Saurabh Agarwal, Roma H. Patel, Sarah Woodfield, Yanling Zhao, Jingling Jin, Hong Zhang, Angela Major, M. John Hicks, Jason M. Shohet, Sanjeev A. Vasudevan, Cristian Coarfa, Jianhua Yang, Jed G. Nuchtern

Published Oct 19, 2017 · Vol. 8, No. 55 · pp. 94780-94792

Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2 Research Paper

Britta Vormoor, Yvonne T. Schlosser, Helen Blair, Abhishek Sharma, Sarah Wilkinson, David R. Newell, Nicola Curtin

Published Sep 28, 2017 · Vol. 8, No. 69 · pp. 113418-113430

Targeting pediatric sarcoma with a bispecific ligand immunotoxin targeting urokinase and epidermal growth factor receptors Research Paper

Kristy Pilbeam, Hongbo Wang, Elizabeth Taras, Rachel J. Bergerson, Brianna Ettestad, Todd DeFor, Antonella Borgatti, Daniel A. Vallera, Michael R. Verneris

Published Sep 23, 2017 · Vol. 9, No. 15 · pp. 11938-11947

Size-based detection of sarcoma circulating tumor cells and cell clusters Research Paper

Masanori Hayashi, Peixuan Zhu, Gregory McCarty, Christian F. Meyer, Christine A. Pratilas, Adam Levin, Carol D. Morris, Catherine M. Albert, Kyle W. Jackson, Cha-Mei Tang, David M. Loeb

Published Aug 24, 2017 · Vol. 8, No. 45 · pp. 78965-78977

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties Research Paper

Atreyi Dasgupta, Matteo Trucco, Nino Rainusso, Ronald J. Bernardi, Ryan Shuck, Lyazat Kurenbekova, David M. Loeb, Jason T. Yustein

Published Aug 24, 2017 · Vol. 8, No. 44 · pp. 77292-77308

Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine Research Paper

Kelli L. Goss, Stacia L. Koppenhafer, Kathryn M. Harmoney, William W. Terry, David J. Gordon

Published Jun 28, 2017 · Vol. 8, No. 50 · pp. 87016-87032

EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells Research Paper

Cornelia N. Mutz, Raphaela Schwentner, Dave N.T. Aryee, Eric D.J. Bouchard, Edgard M. Mejia, Grant M. Hatch, Maximilian O. Kauer, Anna M. Katschnig, Jozef Ban, Antje Garten, Javier Alonso, Versha Banerji, Heinrich Kovar

Published Feb 1, 2017 · Vol. 8, No. 15 · pp. 24679-24693

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Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine Research Paper

Correction: YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Correction

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas Research Paper

KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma Research Paper

Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma through miR-210 delivery Research Paper

Ewing sarcoma family of tumors-derived small extracellular vesicle proteomics identify potential clinical biomarkers Research Paper

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma Research Paper

EWS-FLI1 low Ewing sarcoma cells demonstrate decreased susceptibility to T-cell-mediated tumor cell apoptosis Research Paper

The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth Research Paper

The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma Research Paper

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers Research Paper

IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma Research Paper

T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G Research Paper

EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma Research Paper

Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2 Research Paper

Targeting pediatric sarcoma with a bispecific ligand immunotoxin targeting urokinase and epidermal growth factor receptors Research Paper

Size-based detection of sarcoma circulating tumor cells and cell clusters Research Paper

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties Research Paper

Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine Research Paper

EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine Research Paper

Correction: YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Correction

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas Research Paper

KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma Research Paper

Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma through miR-210 delivery Research Paper

Ewing sarcoma family of tumors-derived small extracellular vesicle proteomics identify potential clinical biomarkers Research Paper

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma Research Paper

EWS-FLI1 low Ewing sarcoma cells demonstrate decreased susceptibility to T-cell-mediated tumor cell apoptosis Research Paper

The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth Research Paper

The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma Research Paper

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers Research Paper

IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma Research Paper

T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G Research Paper

EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma Research Paper

Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2 Research Paper

Targeting pediatric sarcoma with a bispecific ligand immunotoxin targeting urokinase and epidermal growth factor receptors Research Paper

Size-based detection of sarcoma circulating tumor cells and cell clusters Research Paper

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties Research Paper

Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine Research Paper

EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells Research Paper