The Oncosearch | Oncotarget

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Aiden Deacon, Ava Gustafson, Allison Makovec, Ella Boytim, Gabriella von Dohlen, David Moline, Elin Kairies, Sam Kellen, Khalid Ishani, Megan L. Ludwig, Emily John, Alexis Anike, Hai Dang Nguyen, Scott M. Dehm, Justin M. Drake, Emmanuel S. Antonarakis, Justin Hwang

Published Jul 19, 2025 · Vol. 16, No. 1 · pp. 606-620

Keywords: RSPO2, prostate cancer, Wnt signaling, genomics, therapeutics

Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer Research Paper

Sneha Tripathi, Ekta Gupta, Rutika Naik, Satyajeet Khare, Rafeeq Mir, Siddhesh Kamat, Sanjeev Galande

Published Jul 12, 2025 · Vol. 16, No. 1 · pp. 562-581

Keywords: colorectal cancer, statins, SATB1, Wnt/β-catenin signaling, tumor-suppressive phenotype

Deep learning-based uncertainty quantification for quality assurance in hepatobiliary imaging-based techniques Editorial

Yashbir Singh, Jesper B. Andersen, Quincy Hathaway, Sudhakar K. Venkatesh, Gregory J. Gores, Bradley Erickson

Published Mar 30, 2025 · Vol. 16, No. 1 · pp. 249-255

Keywords: deep learning, uncertainty quantification, radiology, hepatobiliary imaging

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Lanlan Zhou, Leiqing Zhang, Jun Zhang, Laura Jinxuan Wu, Shengliang Zhang, Andrew George, Marina Hahn, Howard P. Safran, Clark C. Chen, Attila A. Seyhan, Eric T. Wong, Wafik S. El-Deiry

Published Mar 20, 2025 · Vol. 16, No. 1 · pp. 230-248

Keywords: glioblastoma multiforme, IDH, ONC201, ONC206, MGMT, temozolomide, radiotherapy

Initiation of tumor dormancy by the lymphovascular embolus Research Paper

Yin Ye, Justin Wang, Michael G. Izban, Billy R. Ballard, Sanford H. Barsky

Published Oct 2, 2024 · Vol. 15, No. 1 · pp. 726-740

Keywords: dormancy, lymphovascular embolus, mTOR, E-cadherin proteolysis

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

Md Maksudul Alam, Janmaris Marin Fermin, Mark Knackstedt, Mackenzie J. Noonan, Taylor Powell, Landon Goodreau, Emily K. Daniel, Xiaohua Rong, Tara Moore-Medlin, Alok R. Khandelwal, Cherie-Ann O. Nathan

Published Jan 27, 2023 · Vol. 14, No. 1 · pp. 85-95

Keywords: TP53 mutant, HNSCC, angiogenesis, everolimus, mTOR

Correction: miR-144-3p, a tumor suppressive microRNA targeting ETS-1 in laryngeal squamous cell carcinoma Correction

Si-Yi Zhang, Zhong-Ming Lu, Ye-Feng Lin, Liang-Si Chen, Xiao-Ning Luo, Xin-Han Song, Shao-Hua Chen, Yi-Long Wu

Published Aug 16, 2022

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

Elham Khosrowabadi, Tomasz Wenta, Salla Keskitalo, Aki Manninen, Sakari Kellokumpu

Published Dec 22, 2021 · Vol. 13, No. 1 · pp. 73-89

Keywords: cancer, invasion, glycosylation, glycocode, terminal GalNAc, Helix Pomatia agglutinin (HPA)

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

Monica Sharma, Isabel Castro-Piedras, Fahmida Rasha, Sabarish Ramachandran, Souad R. Sennoune, Kathryn Furr, Sharilyn Almodovar, Vadivel Ganapathy, Matthew B. Grisham, Rakhshanda Layeequr Rahman, Kevin Pruitt

Published Sep 28, 2021 · Vol. 12, No. 22 · pp. 2234-2251

Keywords: dishevelled (DVL), post-translational modification, lysine residue, gene expression, chromatin immunoprecipitation (ChIP)

Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells Research Paper

Jan A. Kaczmarczyk, Rhonda R. Roberts, Brian T. Luke, King C. Chan, Carly M. Van Wagoner, Robin A. Felder, Richard G. Saul, Colantonio Simona, Josip Blonder

Published Sep 3, 2021 · Vol. 12, No. 20 · pp. 2022-2038

Keywords: lung cancer, proteomics, 2D vs. 3D cultured cells, preclinical testing model, drug target discovery

Nanoparticle T cell engagers for the treatment of acute myeloid leukemia Research Paper

Kinan Alhallak, Jennifer Sun, Barbara Muz, Amanda Jeske, Jessica Yavner, Hannah Bash, Chaelee Park, Berit Lubben, Ola Adebayo, Samuel Achilefu, John F. DiPersio, Abdel Kareem Azab

Published Aug 18, 2021 · Vol. 12, No. 19 · pp. 1878-1885

Keywords: acute myeloid leukemia, T cell engagers, nanoparticles, 3D tissue culture model

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target Research Paper

Natsumi Hayashi, Akitaka Yamasaki, Shiho Ueda, Shogo Okazaki, Yoshiya Ohno, Toshiyuki Tanaka, Yuichi Endo, Yoshihisa Tomioka, Kazue Masuko, Takashi Masuko, Reiko Sugiura

Published May 29, 2021 · Vol. 12, No. 13 · pp. 1256-1270

Keywords: CD98, LAT1, monoclonal antibody, NIH/3T3, oncogenicity

Deep learning with deep convolutional neural network using FDG-PET/CT for malignant pleural mesothelioma diagnosis Research Paper

Kazuhiro Kitajima, Hidetoshi Matsuo, Atsushi Kono, Kozo Kuribayashi, Takashi Kijima, Masaki Hashimoto, Seiki Hasegawa, Takamichi Murakami, Koichiro Yamakado

Published May 21, 2021 · Vol. 12, No. 12 · pp. 1187-1196

Keywords: mesothelioma, artificial intelligence, deep learning, FDG (fluorodeoxyglucose), PET-CT (positron emission tomography-computed tomography)

Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network Research Paper

Shweta Kishor Sonawane, Subashchandrabose Chinnathambi

Published May 7, 2021 · Vol. 12, No. 11 · pp. 1083-1099

Keywords: Alzheimer’s disease, Tau protein, Tau PTMs, Tau glycation, Tau glycation inhibition

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Juan Pablo Cerapio, Agnès Marchio, Luis Cano, Ignacio López, Jean-Jacques Fournié, Béatrice Régnault, Sandro Casavilca-Zambrano, Eloy Ruiz, Anne Dejean, Stéphane Bertani, Pascal Pineau

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 475-492

Keywords: hepatitis B virus, indigenous people, integrative genomics, liver cancer

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Harish Potu, Malathi Kandarpa, Luke F. Peterson, Alison Durham, Nicholas J. Donato, Moshe Talpaz

Published Jan 12, 2021 · Vol. 12, No. 3 · pp. 160-172

Keywords: melanoma, deubiquitinase (DUB) enzyme, transcription factors, USP9X, DUB inhibitor

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment Research Paper

Juyeon Ko, April N. Meyer, Martin Haas, Daniel J. Donoghue

Published Dec 23, 2020 · Vol. 12, No. 1 · pp. 22-36

Keywords: metastatic castrate-resistant prostate cancer, spheroid culture, tyrosine kinase inhibitor

MicroRNA-based regulation of Aurora A kinase in breast cancer Research Paper

Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Abram Madimabe Madiehe, Mervin Meyer

Published Nov 6, 2020 · Vol. 11, No. 46 · pp. 4306-4324

Keywords: AURKA, breast cancer therapy, regulatory microRNA, human argonaute, gene expression

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

Rikio Suzuki, Yuka Kitamura, Yoshihiko Nakamura, Hibiki Akashi, Yoshiaki Ogawa, Hiroshi Kawada, Kiyoshi Ando

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 3984-3997

Keywords: pan-RAF inhibitor, Bim, FOXO3a, bortezomib, lenalidomide

MEK is a promising target in the basal subtype of bladder cancer Research Paper

Nathan M. Merrill, Nathalie M. Vandecan, Kathleen C. Day, Phillip L. Palmbos, Mark L. Day, Aaron M. Udager, Sofia D. Merajver, Matthew B. Soellner

Published Oct 3, 2020 · Vol. 11, No. 44 · pp. 3921-3932

Keywords: bladder cancer, drug screen, 3D culture, basal bladder cancer, MEK inhibition

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Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer Research Paper

Deep learning-based uncertainty quantification for quality assurance in hepatobiliary imaging-based techniques Editorial

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Initiation of tumor dormancy by the lymphovascular embolus Research Paper

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

Correction: miR-144-3p, a tumor suppressive microRNA targeting ETS-1 in laryngeal squamous cell carcinoma Correction

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells Research Paper

Nanoparticle T cell engagers for the treatment of acute myeloid leukemia Research Paper

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target Research Paper

Deep learning with deep convolutional neural network using FDG-PET/CT for malignant pleural mesothelioma diagnosis Research Paper

Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment Research Paper

MicroRNA-based regulation of Aurora A kinase in breast cancer Research Paper

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

MEK is a promising target in the basal subtype of bladder cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer Research Paper

Deep learning-based uncertainty quantification for quality assurance in hepatobiliary imaging-based techniques Editorial

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Initiation of tumor dormancy by the lymphovascular embolus Research Paper

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

Correction: miR-144-3p, a tumor suppressive microRNA targeting ETS-1 in laryngeal squamous cell carcinoma Correction

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype Research Paper

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells Research Paper

Nanoparticle T cell engagers for the treatment of acute myeloid leukemia Research Paper

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target Research Paper

Deep learning with deep convolutional neural network using FDG-PET/CT for malignant pleural mesothelioma diagnosis Research Paper

Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment Research Paper

MicroRNA-based regulation of Aurora A kinase in breast cancer Research Paper

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

MEK is a promising target in the basal subtype of bladder cancer Research Paper