Research Papers:

Identification and characterization of novel enhanced cell penetrating peptides for anti-cancer cargo delivery

Xiguang Zhang, Jean Yves Brossas, Christophe Parizot, Jean Marc Zini and Angelita Rebollo _

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Oncotarget. 2018; 9:5944-5957. https://doi.org/10.18632/oncotarget.23179

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Xiguang Zhang1, Jean Yves Brossas1,2, Christophe Parizot2, Jean Marc Zini3 and Angelita Rebollo1

1CIMI Paris, Inserm 1135, UPMC, 75013 Paris, France

2Hôpital Pitié Salpêtrière, AP-HP, Department of Immunology, 75013 Paris, France

3Hôpital Saint Louis, AP HP, 75010 Paris, France

Correspondence to:

Angelita Rebollo, email: [email protected]

Keywords: cell penetrating peptides; peptide internalization; peptide stablity

Received: September 24, 2017     Accepted: November 16, 2017     Published: December 11, 2017


Cell penetrating peptides (CPP) are able cross the membrane and to transport cargos, presenting a great potential in drug delivery and diagnosis. In this paper, we have identified novel natural or synthetic CPPs. We have validated their rapid and efficient time and dose-dependent penetration, the absence of toxicity, the intracellular localization and the stability to proteases degradation, one of the main bottlenecks of peptides. Moreover, we have associate a cargo (an interfering peptide blocking the association of the serine/threonine phosphatase PP2A to its inhibitor, the oncogene SET) to the new generated shuttles and showed that they new bi-functional peptides keep the original properties of the shuttle and, in addition, are able to induce apoptosis due to the properties of the cargo. The CPPs identified in this study have promising perspectives for future anti-cancer drug delivery.

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