Oncotarget

Research Papers:

Comparisons of short-term and survival outcomes of laparoscopy-assisted versus open total gastrectomy for gastric cancer patients

Xin-Zu Chen, Shao-Yong Wang, Yin-Su Wang, Zi-Han Jiang, Wei-Han Zhang, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Meng Qiu, Hong-Feng Gou, Zong-Guang Zhou and Jian-Kun Hu _

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Oncotarget. 2017; 8:52366-52380. https://doi.org/10.18632/oncotarget.17019

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Abstract

Xin-Zu Chen1,2,*, Shao-Yong Wang1,3,*, Yin-Su Wang4, Zi-Han Jiang4, Wei-Han Zhang1,2, Kai Liu1,2, Kun Yang1,2, Xiao-Long Chen1,2, Lin-Yong Zhao1,2, Meng Qiu5, Hong-Feng Gou5, Zong-Guang Zhou1,6 and Jian-Kun Hu1,2

1Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China

2Institute of Gastric Cancer, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

3Department of Gastrointestinal Surgery, Guizhou Provincial People's Hospital, Guiyang, China

4Faculty of Medicine, West China Medical School, Sichuan University, Chengdu, China

5Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

6Institute of Digestive Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

*These authors equally contributed to this work and are co-first authors

Correspondence to:

Jian-Kun Hu, email: hujkwch@126.com

Keywords: gastric cancer, laparoscopy, gastrectomy, survival, surgical oncology

Received: November 14, 2016     Accepted: March 30, 2017     Published: April 10, 2017

ABSTRACT

Objectives: The safety and surgical oncology of laparoscopy-assisted total gastrectomy (LATG) remain inconclusive and challenging. This study aimed to compare the short-term and long-term outcomes between LATG and open total gastrectomy (OTG) procedures.

Results: In the all-included analyses, there were 69 patients in the LATG group and 268 in the OTG group. LATG was as safe as OTG without increasing postoperative morbidity and mortality. Stage imbalance might introduce differences in the numbers of harvested lymph nodes in LATG (34.4 ± 12.0) and OTG (40.9 ± 16.9), whereas 95.7% of patients underwent D2/D2+ dissection during the LATG procedure. After a median 31 months of follow-up, the overall survival outcomes were comparable between the LATG and OTG procedures (HR = 1.16, 95% CI 0.68–1.97). Sensitivity analysis found comparable node retrieval and stage-specific or treatment-specific overall survival.

Materials and Methods: A retrospective case-control study was conducted among gastric cancer patients who underwent either LATG or OTG with curative intention between June 2006 and December 2015. Data retrieval was based on the Surgical Gastric Cancer Patient Registry in the West China Hospital. The primary outcome was overall survival. The secondary outcomes were postoperative complication incidence and severity, operation duration, blood loss, number of harvested lymph nodes, and postoperative hospital stay. Matched pairwise case-control comparisons were performed as a sensitivity analysis.

Conclusions: LATG by experienced surgeons possibly has comparable short-term surgical outcomes and long-term survival outcomes compared with OTG for gastric cancer patients. However, high-quality RCTs are necessary before confirmative judgment and recommendation as an optional treatment in general practice.


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