Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia

Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds

Efficacy of ATR inhibitors as single agents in Ewing sarcoma

Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer’s disease

Repetitive transcranial magnetic stimulation (rTMS) improves behavioral and biochemical deficits in levodopa-induced dyskinetic rats model

Boar seminal plasma exosomes maintain sperm function by infiltrating into the sperm membrane

Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling

Anaplastic lymphoma kinase aberrations correlate with metastatic features in pediatric rhabdomyosarcoma

Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells

Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway

The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent

Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis

PreImplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies

Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation

VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease

Tobacco smoking and methylation of genes related to lung cancer development

A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis

Comparison of small biopsy specimens and surgical specimens for the detection of EGFR mutations and EML4-ALK in non-small-cell lung cancer

Molecular characteristics of circulating tumor cells resemble the liver metastasis more closely than the primary tumor in metastatic colorectal cancer

The microRNA signature of patients with sunitinib failure: regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma

Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer

Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases

Single-strand DNA library preparation improves sequencing of formalin-fixed and paraffin-embedded (FFPE) cancer DNA

Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia

Loss of ZFP36 expression in colorectal cancer correlates to wnt/ β-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1

PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas

Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells

Prediction and diagnosis of renal cell carcinoma using nuclear magnetic resonance-based serum metabolomics and self-organizing maps

Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells

Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas

Xanthine oxidoreductase is required for genotoxic stress-induced NKG2D ligand expression and gemcitabine-mediated antitumor activity

Apatinib inhibits cellular invasion and migration by fusion kinase KIF5B-RET via suppressing RET/Src signaling pathway

FOXM1 confers resistance to gefitinib in lung adenocarcinoma via a MET/AKT-dependent positive feedback loop

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia

Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia

MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2

Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage

Positive nuclear BAP1 immunostaining helps differentiate non-small cell lung carcinomas from malignant mesothelioma

Preclinical activity of melflufen (J1) in ovarian cancer

Establishment of a large panel of patient-derived preclinical models of human renal cell carcinoma

Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells

XB130 is overexpressed in prostate cancer and involved in cell growth and invasion

HDAC10 promotes lung cancer proliferation via AKT phosphorylation

Novel miR-122 delivery system based on MS2 virus like particle surface displaying cell-penetrating peptide TAT for hepatocellular carcinoma

A general strategy to optimize immunogenicity of HLA-B*0702 restricted cryptic peptides from tumor associated antigens: Design of universal neo-antigen like tumor vaccines for HLA-B*0702 positive patients

IL-1β-stimulated β-catenin up-regulation promotes angiogenesis in human lung-derived mesenchymal stromal cells through a NF-κB-dependent microRNA-433 induction

TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: a potential novel approach to the treatment of metastatic colorectal cancer

Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells

A novel anti-PSMA human scFv has the potential to be used as a diagnostic tool in prostate cancer

Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in Apc^Min/+ mice

Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells

The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis

hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett’s esophagus and can be exploited for a novel endoscopic surveillance

Metformin use and cervical cancer risk in female patients with type 2 diabetes

Long non-coding RNA stabilizes the Y-box-binding protein 1 and regulates the epidermal growth factor receptor to promote lung carcinogenesis

Oleandrin induces DNA damage responses in cancer cells by suppressing the expression of Rad51

Association of lncRNA H19 rs217727 polymorphism and cancer risk in the Chinese population: a meta-analysis

Ago-RIP-Seq identifies Polycomb repressive complex I member CBX7 as a major target of miR-375 in prostate cancer progression

Large intergenic non-coding RNA-ROR reverses gemcitabine-induced autophagy and apoptosis in breast cancer cells

Statins dose-dependently exert a chemopreventive effect against lung cancer in COPD patients: a population-based cohort study

A nomogram composed of clinicopathologic features and preoperative serum tumor markers to predict lymph node metastasis in early gastric cancer patients

High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer

Interleukin-11 promotes epithelial-mesenchymal transition in anaplastic thyroid carcinoma cells through PI3K/Akt/GSK3β signaling pathway activation

Plasma miR-324-3p and miR-1285 as diagnostic and prognostic biomarkers for early stage lung squamous cell carcinoma

Dysregulated long intergenic non-coding RNA modules contribute to heart failure

Dihydromyricetin promotes autophagy and apoptosis through ROS-STAT3 signaling in head and neck squamous cell carcinoma

IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens

miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1

Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation

The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese population

Chemo-immunotherapy induces tumor regression in a mouse model of spontaneous mammary carcinogenesis

Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells

Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide

Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells

Dichloroacetate potentiates tamoxifen-induced cell death in breast cancer cells via downregulation of the epidermal growth factor receptor

Improved survival of patients with hepatocellular carcinoma and disparities by age, race, and socioeconomic status by decade, 1983–2012

The 3′UTR signature defines a highly metastatic subgroup of triple-negative breast cancer

MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells

Simultaneous targeting of Eph receptors in glioblastoma

Combined cell surface carbonic anhydrase 9 and CD147 antigens enable high-efficiency capture of circulating tumor cells in clear cell renal cell carcinoma patients

Blood concentration of cyclosporine during early post-transplant period may have influence on the occurrence of chronic graft versus host disease in patients who received allogeneic hematopoietic stem cell transplantation

Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes

Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation

MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells

Whether regional lymph nodes evaluation should be equally required for both right and left colon cancer

Endoplasmic reticulum stress induces secretion of high-mobility group proteins and is associated with tumor-infiltrating lymphocytes in triple-negative breast cancer

A lupus anti-DNA autoantibody mediates autocatalytic, targeted delivery of nanoparticles to tumors

PD-L1 expression in EBV-negative diffuse large B-cell lymphoma: clinicopathologic features and prognostic implications

MALDI imaging reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis

The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation

Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients

Nucleophosmin/B23 is a negative regulator of estrogen receptor α expression via AP2γ in endometrial cancer cells

Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis

Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia

RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy

Short term ex-vivo expansion of circulating head and neck tumour cells

The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling

Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells

The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA

Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC

Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640

Site-specific associations between miRNA expression and survival in colorectal cancer cases

Involvement of urokinase receptor in the cross-talk between human hematopoietic stem cells and bone marrow microenvironment

DNA aneuploidy and breast cancer: a meta-analysis of 141,163 cases

MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway

Sensitivity to PRIMA-1^MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status

Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics

Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway

MiR-155 and its functional variant rs767649 contribute to the susceptibility and survival of hepatocellular carcinoma

Wnt signalling is a bi-directional vulnerability of cancer cells

Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer

Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis

Acetylation of FOXM1 is essential for its transactivation and tumor growth stimulation

Spatial distribution of FoxP3+ and CD8+ tumour infiltrating T cells reflects their functional activity

Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings

Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER−/Her2+ breast cancer

Smoking, second-hand smoke exposure and smoking cessation in relation to leukocyte telomere length and mortality

Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells

Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APC^Min/+ mice

IL-2 augments the therapeutic efficacy of adoptively transferred B cells which directly kill tumor cells via the CXCR4/CXCL12 and perforin pathways

A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts

An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells

Identification of androgen-responsive lncRNAs as diagnostic and prognostic markers for prostate cancer

USP9X destabilizes pVHL and promotes cell proliferation

Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system

Evaluation of DNMT3A genetic polymorphisms as outcome predictors in AML patients

Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells

Downregulation of homeobox gene Barx2 increases gastric cancer proliferation and metastasis and predicts poor patient outcomes

Activated platelets inhibit hepatocellular carcinoma cell differentiation and promote tumor progression via platelet-tumor cell binding

CD151-mediated adhesion is crucial to osteosarcoma pulmonary metastasis

Better pathologic complete response and relapse-free survival after carboplatin plus paclitaxel compared with epirubicin plus paclitaxel as neoadjuvant chemotherapy for locally advanced triple-negative breast cancer: a randomized phase 2 trial

Increased expression of αTubulin is associated with poor prognosis in patients with pancreatic cancer after surgical resection

Treatment of primary intracranial germ cell tumors: Single center experience with 42 clinically diagnosed cases

Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women

Microenvironment drug resistance in multiple myeloma: emerging new players

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway

Role of micro-RNAs in drug resistance of multiple myeloma

The functions and clinical applications of tumor-derived exosomes

Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?