Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression

Nan Cui; Wen-Ting Yang; Peng-Sheng Zheng

doi:10.18632/oncotarget.8434

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Research Papers:

Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression

Nan Cui, Wen-Ting Yang and Peng-Sheng Zheng _

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Oncotarget. 2016; 7:26152-26167. https://doi.org/10.18632/oncotarget.8434

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Abstract

Nan Cui1,2, Wen-Ting Yang1,3, Peng-Sheng Zheng1,3

1Department of Reproductive Medicine, First Affiliated Hospital, Xi’an Jiaotong University Medical School, Xi’an, The People’s Republic of China

2Department of Biochemistry and Molecular Biology, Xi’an Jiaotong University Medical School, Xi’an, The People’s Republic of China

3Section of Cancer Stem Cell Research, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of The People's Republic of China, Xi'an, The People's Republic of China

Correspondence to:

Peng-Sheng Zheng, email: [email protected]

Keywords: Slug, Akt1, Wnt/β-catenin, cervical cancer, proliferation

Received: January 05, 2016 Accepted: March 14, 2016 Published: March 28, 2016

ABSTRACT

Slug (Snai2) has been demonstrated to act as an oncogene or tumor suppressor in different human cancers, but the function of Slug in cervical cancer remains poorly understood. In this study, we demonstrated that Slug could suppress the proliferation of cervical cancer cells in vitro and tumor formation in vivo. Further experiments found that Slug could trans-suppress the expression of Akt1/p-Akt1 by binding to E-box motifs in the promoter of the Akt1 gene and then inhibit the cell proliferation and tumor formation of cervical cancer cells by up-regulating p21/p27 and/or down-regulating the activity of the Wnt/β-catenin signaling pathway. Therefore, Slug acts as a tumor suppressor during cervical carcinogenesis.

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Research Papers:

Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression

Abstract