Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer

Yuan Yang; Wenjing Wang; Liangcai Zhang; Shihua Zhang; Guiyou Liu; Yingcui Yu; Mingzhi Liao

doi:10.18632/oncotarget.8186

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer

Yuan Yang _, Wenjing Wang, Liangcai Zhang, Shihua Zhang, Guiyou Liu, Yingcui Yu and Mingzhi Liao

PDF | HTML | How to cite

Oncotarget. 2016; 7:25528-25534. https://doi.org/10.18632/oncotarget.8186

Metrics: PDF 1759 views | HTML 1754 views | ?

Abstract

Yuan Yang1,2, Wenjing Wang1,3, Liangcai Zhang4, Shihua Zhang5, Guiyou Liu6, Yingcui Yu7, Mingzhi Liao1

1College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China

2School of Life Sciences, Fudan University, Shanghai, China

3Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China

4Department of Statistics, Rice University, Houston, TX, USA

5Department of Biostatistics, School of Science, Anhui Agricultural University, Hefei, China

6Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

7College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, China

Correspondence to:

Mingzhi Liao, e-mail: [email protected]

Yingcui Yu, e-mail: [email protected]

Keywords: prostate cancer, rs6983267, meta-analysis, risk, association

Received: January 10, 2016 Accepted: March 04, 2016 Published: March 18, 2016

ABSTRACT

Many studies have investigated the association between single nucleotide polymorphism (SNP) rs6983267 and the risk of prostate cancer. However, results of these studies are inconsistent. Therefore, we summarised available data and performed a meta-analysis to determine this association. Relevant articles were identified by searching the PubMed, Web of Science and Embase database. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random effects model. We used dominant model (GG + TG vs TT), recessive model (GG vs TG + TT) and additive model (GG +TT vs TG) to determine the association between the rs6983267 polymorphism and risk of prostate cancer. Summary, 9 studies involving 8726 participants were included in this meta-analysis. Overall, though no association was observed between the rs6983267 polymorphism and risk of prostate cancer, subgroup analysis according to ethnicity showed a significant association between the rs6983267 polymorphism and risk of prostate cancer among white European men [recessive model: GG vs TG + TT, OR=1.21, (95% CI: 1.03, 1.42), P=0.02]. Our results indicate that the GG genotype of the rs6983267 polymorphism will increase individual susceptibility to prostate cancer in white European men.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 8186

Publication Alerts

Research Papers:

Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer

Abstract