The role of MicroRNAs expression in laryngeal cancer

Xin Yu; Zheng Li

doi:10.18632/oncotarget.4195

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The role of MicroRNAs expression in laryngeal cancer

Xin Yu _ and Zheng Li

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Oncotarget. 2015; 6:23297-23305. https://doi.org/10.18632/oncotarget.4195

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Abstract

Xin Yu1,*, Zheng Li1,*

1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Zheng Li, e-mail: [email protected]

Keywords: laryngeal cancer, miRNAs, oncogene, tumor suppressor gene

Received: April 10, 2015 Accepted: May 23, 2015 Published: June 05, 2015

ABSTRACT

MicroRNAs (miRs, miRs) is a class of small non-coding RNAs, which posttranscriptionally regulate gene expression. Deregulated miRs are frequently obseved in patients with laryngeal cancer. In addition, numerous studies have showed miRs play significant roles in the pathogenesis of laryngeal cancer through regulating tumor cell proliferation, metastasis, invasion and apoptosis. miR can play either an oncogenic or tumor suppressive role in laryngeal cancer. In our review, we summarize the recent researches on laryngeal cancer-associated miRs, focusing on their role in the pathogenesis of laryngeal cancer. As changes in the levels of specific miRs in tissues or serum associate with diagnosis and prognosis of patients, we will also discuss the potential use of miRs in laryngeal cancer diagnosis and prognosis. Furthermore, supplementation of oncomiRs or inhibition of tumor suppressive miRs in vivo may be future therapeutic strategy for laryngeal cancer.

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Reviews:

The role of MicroRNAs expression in laryngeal cancer

Abstract