Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Hong-Jian Wei; Rong Zeng; Jui-Hua Lu; Wen-Fu T. Lai; Wei-Hong Chen; Hen-Yu Liu; Ya-Ting Chang; Win-Ping Deng

doi:10.18632/oncotarget.3481

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Hong-Jian Wei, Rong Zeng, Jui-Hua Lu, Wen-Fu T. Lai, Wei-Hong Chen, Hen-Yu Liu, Ya-Ting Chang and Win-Ping Deng _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2015; 6:7713-7726. https://doi.org/10.18632/oncotarget.3481

Metrics: PDF 2937 views | HTML 3076 views | ?

Abstract

Hong-Jian Wei1,2, Rong Zeng3, Jui-Hua Lu1, Wen-Fu T. Lai4, Wei-Hong Chen2, Hen-Yu Liu2, Ya-Ting Chang1 and Win-Ping Deng1,2,3

1 Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan

2 Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan

3 Department of Orthopedic Surgery, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, China

4 Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan

Correspondence to:

Win-Ping Deng, email:

Keywords: Adipose-derived stem cells, Tumor initiation, Cancer stem cell, Breast cancer, Colon cancer

Received: October 20, 2015 Accepted: February 03, 2015 Published: March 08, 2015

Abstract

Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 3481

Publication Alerts

Research Papers:

Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Abstract