PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis

Guiling Wang; Yanyan Song; Tong Liu; Chunyu Wang; Qing Zhang; Furong Liu; Xinze Cai; Zhifeng Miao; Hongde Xu; Huimian Xu; Liu Cao; Feng Li

doi:10.18632/oncotarget.3185

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis

Guiling Wang, Yanyan Song, Tong Liu, Chunyu Wang, Qing Zhang, Furong Liu, Xinze Cai, Zhifeng Miao, Hongde Xu, Huimian Xu, Liu Cao and Feng Li _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2015; 6:9877-9886. https://doi.org/10.18632/oncotarget.3185

Metrics: PDF 2836 views | HTML 3214 views | ?

Abstract

Guiling Wang1, Yanyan Song1, Tong Liu1, Chunyu Wang1, Qing Zhang1, Furong Liu1, Xinze Cai1, Zhifeng Miao2, Hongde Xu1, Huimian Xu2, Liu Cao1, Feng Li1

1Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

2Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, China

Correspondence to:

Feng Li, e-mail: [email protected]

Guiling Wang, e-mail: [email protected]

Keywords: MORC2, phosphorylation, P21-activated kinase 1(PAK1), gastric cancer

Received: November 23, 2014 Accepted: January 23, 2015 Published: March 21, 2015

ABSTRACT

To date, microrchidia (MORC) family CW-type zinc-finger 2 (MORC2), has been found to be involved in p21-activated kinase1 (PAK1) pathway to maintain genomic integrity. Here, we explore its novel role in cancer. We demonstrate that PAK1-mediated MORC2 phosphorylation promotes cell cycle progression, defective phosphorylation of MORC2-S677A results in attenuated cell proliferation and tumorigenicity of gastric cancer cells, which is significantly enhanced in overexpression of phospho-mimic MORC2-S677E form, suggesting the importance of MORC2 phosphorylation in tumorigenesis. More importantly, phosphorylation of MORC2 correlates positively with PAK1 expression in clinical gastric cancer. Furthermore, high expression of PAK1 and phosphorylation of MORC2 appear to be associated with poor prognosis of clinical gastric cancer. Collectively, these findings revealed a novel function of MORC2 phosphorylation in promoting gastric cell proliferation in vitro and tumorigenesis in vivo, suggesting that blocking PAK1-mediated MORC2 phosphorylation might be a potential therapeutic strategy for gastric tumorigenesis.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 3185

Publication Alerts

Research Papers:

PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis

Abstract