Serum fetuin A level is associated with nonalcoholic fatty liver disease in Chinese population

Zhengsen Cui; Rong Xuan; Yunmei Yang

doi:10.18632/oncotarget.22361

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Serum fetuin A level is associated with nonalcoholic fatty liver disease in Chinese population

Zhengsen Cui, Rong Xuan and Yunmei Yang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:107149-107156. https://doi.org/10.18632/oncotarget.22361

Metrics: PDF 1294 views | HTML 1998 views | ?

Abstract

Zhengsen Cui1,*, Rong Xuan2,* and Yunmei Yang1

1Department of Geratology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China

2Department of Endocrine, The Third Hospital of Hangzhou, Hangzhou, 310000, China

*These authors have contributed equally to the work

Correspondence to:

Yunmei Yang, email: [email protected]

Keywords: fetuin A; non-alcoholic fatty liver disease; metabolic disorder; insulin resistance; serum biomarker

Received: July 14, 2017 Accepted: September 23, 2017 Published: November 10, 2017

ABSTRACT

Objective: To investigate the association between serum fetuin A concentration and non-alcoholic fatty liver disease (NAFLD) in Chinese population.

Methods: This case-control study enrolled 79 NAFLD cases and 79 non-NAFLD controls. All subjects were selected from Chinese population who received annual health examination in the First Affiliated Hospital of Zhejiang University in 2016. NAFLD was diagnosed mainly based on abdominal ultrasonography. The severity of NAFLD was categorized by serum level of alanine aminotransferase. Serum fetuin A was measured by ELISA.

Results: Serum fetuin A level in NAFLD patients was significantly lower than that in controls (0.27±0.17 vs. 0.32±0.12g/L, P < 0.05). Compared with controls, mild NAFLD (0.24±0.16 g/L, P < 0.05) and moderate NAFLD (0.25±0.17 g/L, P < 0.05) had significantly lower concentration of fetuin A, while fetuin A level tended to slightly increase with the severity of NAFLD. The prevalence rate of NAFLD decreased (75 %, 40 %, and 36 %), as fetuin A level elevated. ROC curve of fetuin A was developed to predict the presence of NAFLD. Area under ROC was 0.656.

Conclusion: Serum level of fetuin A was lower in NAFLD patients than controls, while fetuin A level increased with the severity of NAFLD, indicating a potential predicting role of fetuin A in the development of NAFLD.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 22361

Publication Alerts

Research Papers:

Serum fetuin A level is associated with nonalcoholic fatty liver disease in Chinese population

Abstract