Oncotarget

Research Papers:

This article has been corrected. Correction in: Oncotarget. 2018; 9:36816.

Cutaneous melanoma primary site is linked to nevus density

Alejandro Martin-Gorgojo, Marta Llinares, Amaya Virós, Celia Requena, Zaida Garcia-Casado, Víctor Traves, Rajiv Kumar and Eduardo Nagore _

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Oncotarget. 2017; 8:98876-98886. https://doi.org/10.18632/oncotarget.22016

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Abstract

Alejandro Martin-Gorgojo1,*, Marta Llinares2,*, Amaya Virós3,4,*, Celia Requena2, Zaida Garcia-Casado5, Víctor Traves6, Rajiv Kumar7 and Eduardo Nagore2,8

1Escuela de Doctorado, Universidad Católica de Valencia “San Vicente Mártir”, Valencia, Spain

2Department of Dermatology, Instituto Valenciano de Oncologia (IVO), Valencia, Spain

3Skin Cancer and Ageing Laboratory, CRUK Manchester Institute, Manchester, UK

4Salford Royal NHS Foundation Trust, Manchester, UK

5Department of Molecular Biology, Instituto Valenciano de Oncologia (IVO), Valencia, Spain

6Department of Pathology, Instituto Valenciano de Oncologia (IVO), Valencia, Spain

7Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany

8Dermatology Department, School of Medicine, Universidad Católica de València “San Vicente Mártir”, Valencia, Spain

*These authors have contributed equally to this work

Correspondence to:

Eduardo Nagore, email: [email protected]

Keywords: melanoma; nevus; risk; sunburn; solar elastosis

Received: July 20, 2017    Accepted: September 23, 2017    Published: October 24, 2017

ABSTRACT

There are at least two pathways driving cutaneous melanoma; one is linked to an inherent melanoma susceptibility to nevi development and the second to environmental cumulative ultraviolet light exposure. In this study, we examined the relation between nevus density, accrued sun damage and the site of primary melanoma excision.

In a series of 888 consecutive cutaneous melanoma patients, melanomas appearing in skin areas with a high relative nevus density were most prominent in men, with an elevated nevus count, at sites without solar elastosis, but with an epidemiological history of previous sunburn.

The present study associates melanoma development to sites with high nevus density. Our study supports more careful surveillance of body areas with increased nevus density in patients with high total body number of nevi, especially when they report a history of sunburns at these sites.


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PII: 22016