ALV-J infection induces chicken monocyte death accompanied with the production of IL-1β and IL-18

Manman Dai; Min Feng; Tingting Xie; Yuanfang Li; Zhuohao Ruan; Meiqing Shi; Ming Liao; Xiquan Zhang

doi:10.18632/oncotarget.21906

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Research Papers:

ALV-J infection induces chicken monocyte death accompanied with the production of IL-1β and IL-18

Manman Dai, Min Feng, Tingting Xie, Yuanfang Li, Zhuohao Ruan, Meiqing Shi, Ming Liao _ and Xiquan Zhang

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Oncotarget. 2017; 8:99889-99900. https://doi.org/10.18632/oncotarget.21906

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Abstract

Manman Dai1,*, Min Feng2,3,*, Tingting Xie2,3, Yuanfang Li2,3, Zhuohao Ruan2,3, Meiqing Shi4, Ming Liao1 and Xiquan Zhang2,3

1College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

2Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China

3Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, Guangdong, China

4Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

*These authors contributed equally to this work

Correspondence to:

Ming Liao, email: [email protected]

Xiquan Zhang, email: [email protected]

Keywords: ALV-J, monocyte, pyroptosis, immunosuppression, chicken macrophage

Received: July 12, 2017 Accepted: September 23, 2017 Published: October 13, 2017

ABSTRACT

Immunosuppression induced by avian leukosis virus subgroup J (ALV-J) causes serious reproduction problems and secondary infections in chickens. Given that monocytes are important precursors of immune cells including macrophages and dendritic cells, we investigated the fate of chicken monocytes after ALV-J infection. Our results indicated that most monocytes infected with ALV-J including field or laboratory strains could not successfully differentiate into macrophages due to cells death. And cells death was dependent upon viral titer and accompanied with increased IL-1β and IL-18 mRNA levels. In addition, ALV-J infection up-regulated caspase-1 and caspase-3 activity in monocytes. Collectively, we found that ALV-J could cause cell death in chicken monocytes, especially pyroptosis, which may be a significant reason for ALV-J induced immunosuppression.

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Research Papers:

ALV-J infection induces chicken monocyte death accompanied with the production of IL-1β and IL-18

Abstract