Association of variant in the ADIPOQ gene and functional study for its role in atherosclerosis

Xinzhong Chen; Yanhong Yuan; Yufeng Gao; Qin Wang; Fei Xie; Dongsheng Xia; Yutao Wei; Ting Xie

doi:10.18632/oncotarget.21232

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Research Papers:

Association of variant in the ADIPOQ gene and functional study for its role in atherosclerosis

Xinzhong Chen _, Yanhong Yuan, Yufeng Gao, Qin Wang, Fei Xie, Dongsheng Xia, Yutao Wei and Ting Xie

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Oncotarget. 2017; 8:86527-86534. https://doi.org/10.18632/oncotarget.21232

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Abstract

Xinzhong Chen1, Yanhong Yuan1, Yufeng Gao2, Qin Wang1, Fei Xie1, Dongsheng Xia3, Yutao Wei1 and Ting Xie4

1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

2Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

3Department of Cardiovascular Surgery, Henan Provincial People’s Hospital, Zhengzhou, 450003, China

4Department of Cardiac Surgery, Hainan Provincial People’s Hospital, Hainan 570311, China

Correspondence to:

Xinzhong Chen, email: [email protected]

Keywords: ADIPOQ, adiponectin, atherosclerosis, polymorphism

Received: June 13, 2017 Accepted: August 04, 2017 Published: September 23, 2017

ABSTRACT

The burden of atherosclerosis is heritable and associated with elevated risk of developing CVDs. Here, we evaluated genetic variants of adiponectin (ADIPOQ) gene, which has important role in anti- atherosclerosis, with risk of atherosclerosis among a large Chinese population. Our results show that rs74577862 was significantly associated with risk of atherosclerosis (OR=2.08; 95%CI=1.48-2.91; P=2.2×10^-5). When stratified by atherosclerosis site, rs74577862 was associated with increased risk of both carotid atherosclerosis (OR=2.03; 95%CI=1.35-3.06; P=6.3×10-4) and coronary atherosclerosis (OR=2.11; 95%CI=1.44-3.09; P=1.1×10-4). In addition, we also carried out site-directed mutagenesis and dual-luciferase reporter assay to confirm the positive finding, which presents a significant decrease in luciferase expression for the reconstructed plasmid with rs74577862 A allele in comparison to the one with G allele (P<0.001). Real-time PCR also confirmed the findings above. These results strongly suggest that the functional SNP, ADIPOQ rs74577862 might contribute to atherosclerosis susceptibility.

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Research Papers:

Association of variant in the ADIPOQ gene and functional study for its role in atherosclerosis

Abstract