Smoking and risk of cholangiocarcinoma: a systematic review and meta-analysis

Yuenan Huang; Liuping You; Weimin Xie; Li Ning; Jinghe Lang

doi:10.18632/oncotarget.20141

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Meta-Analysis:

Smoking and risk of cholangiocarcinoma: a systematic review and meta-analysis

Yuenan Huang _, Liuping You, Weimin Xie, Li Ning and Jinghe Lang

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Oncotarget. 2017; 8:100570-100581. https://doi.org/10.18632/oncotarget.20141

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Abstract

Yuenan Huang1,*, Liuping You1,*, Weimin Xie2,*, Li Ning2,* and Jinghe Lang2

1Department of General Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China

2Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

*These authors contributed equally to this work

Correspondence to:

Yuenan Huang, email: [email protected]

Keywords: smoking, cholangiocarcinoma, risk, meta-analysis

Received: May 01, 2017 Accepted: July 30, 2017 Published: August 10, 2017

ABSTRACT

Previous studies evaluating the association between smoking and risk of cholangiocarcinoma (CCA) have yielded controversial results. We conducted a meta-analysis to evaluate the association based on available evidence. We searched the databases of Embase, PubMed and Cochrane Central Register of Controlled Trials from inception to April 11, 2017. Studies that investigated the association between smoking and risk of CCA were included. Pooled odds ratio (OR) estimates and 95% confidence intervals (CIs) were calculated using either a random-effects or a fixed-effects model. A total of 22 studies involving 324,333 participants were identified. The summary OR of CCA was 1.31 (95% CI, 1.15 to 1.51) for smokers versus nonsmokers. The increased risk was independent of diabetes mellitus, bilious tract stone disease, and liver cirrhosis. Smokers also had increased risk of intrahepatic CCA (12 studies; OR, 1.31; 95% CI, 1.06 to 1.63) and extrahepatic CCA (12 studies; OR, 1.32; 95% CI, 1.10 to 1.59) compared with nonsmokers. The results of our meta-analysis support the hypothesis that there is a moderate association between cigarette smoking and risk of CCA.

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Meta-Analysis:

Smoking and risk of cholangiocarcinoma: a systematic review and meta-analysis

Abstract