Oncotarget

Meta-Analysis:

Long non-coding RNAs for osteosarcoma in the mouse: a meta-analysis

Shaopu Hu, Junli Chang, Yimian Li, Wenyi Wang, Edward C. Zou, Mengyao Guo, Qi Shi, Yongjun Wang and Yanping Yang _

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Oncotarget. 2017; 8:100533-100544. https://doi.org/10.18632/oncotarget.20128

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Abstract

Shaopu Hu1,2,*, Junli Chang1,2,*, Yimian Li1,2, Wenyi Wang1,2, Edward C. Zou3, Mengyao Guo1,2, Qi Shi1,2, Yongjun Wang1,2,4 and Yanping Yang1,2

1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China

2Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, 200032, China

3Consulting Engagement Management, Cerner, Kansas City, MO 64117, USA

4School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

*These authors contributed equally to this work

Correspondence to:

Yanping Yang, email: [email protected]

Keywords: lncRNA, osteosarcoma, meta-analysis, mice

Received: April 21, 2017     Accepted: July 30, 2017     Published: August 10, 2017

ABSTRACT

Osteosarcoma, one of the most common primary bone malignances, is a leading cause of cancer death among children and adolescents. Recently, growing studies have found that long non-coding RNAs (lncRNAs) can interfere with the expression of various genes, and participate in the occurrence and development of malignancies. The purpose of this study is to evaluate the potential functions of lncRNAs as diagnostic biomarkers and therapeutic targets for osteosarcoma in mice, thus to direct the strict design for the future preclinical experiments and clinical trials. We systematically searched PubMed, Web of Science, Embase, China Knowledge Resource Integrated Database, VIP, Chinese BioMedical and Wan Fang Database from their initiation date to June 20, 2017. Two researchers independently screened the literatures and withdrew the data, which used the tumor volume and tumor weight as the outcome measures. A total of 10 studies were included, and the results of this meta-analysis revealed that lncRNAs could serve as the diagnostic biomarkers and therapeutic targets for osteosarcoma; and progression of osteosarcoma in mice could be inhibited via rescuing the abnormally expressed lncRNAs. It is necessary to carry out more rigorous basic experiments before lncRNAs can be further investigated in the clinical trials and used in future clinical practices.


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