Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization

Honghui Yang; Yan Chen; Chuanyu Gao

doi:10.18632/oncotarget.20111

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Research Papers:

Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization

Honghui Yang _, Yan Chen and Chuanyu Gao

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Oncotarget. 2017; 8:99495-99503. https://doi.org/10.18632/oncotarget.20111

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Abstract

Honghui Yang1, Yan Chen1 and Chuanyu Gao1

1Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou 450001, China

Correspondence to:

Honghui Yang, email: [email protected]

Keywords: IL-13, viral myocarditis, macrophage polarization

Received: July 02, 2017 Accepted: July 26, 2017 Published: August 10, 2017

ABSTRACT

Viral myocarditis is one of the major causes of congestive heart failure and dilated cardiomyopathy. Recent reports have demonstrated an essential role of cytokines, like interleukin-13 (IL-13), in the pathogenesis of viral myocarditis, while the underlying mechanisms remain poorly defined. Here, using a coxsackie virus B3 (CVB3)-infection model in BALB/C mice, we showed that IL-13 protected mouse heart function in viral myocarditis, seemingly through reduction in T lymphocyte immunity and induction of M2 macrophage polarization. Adoptive transfer to M2 macrophages mimicked the effects of IL-13 on protection from myocarditis, suggesting that the effects of IL-13 may be primarily through regulation of macrophage polarization. Together, our data suggest that application of IL-13 treatment may reduce cardiac Injury and protect heart function in viral myocarditis via enhanced M2 macrophage polarization.

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Research Papers:

Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization

Abstract