G-T haplotype established by rs3785889-rs16941382 in  GOSR2  gene is associated with coronary artery disease in Chinese Han population

Shuo Pan; Gong-Chang Guan; Ying Lv; Zhong-Wei Liu; Fu-Qiang Liu; Yong Zhang; Shun-Ming Zhu; Rong-Huai Zhang; Na Zhao; Shuang Shi; Tomohiro Nakayama; Jun-Kui Wang

doi:10.18632/oncotarget.19280

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Research Papers:

G-T haplotype established by rs3785889-rs16941382 in GOSR2 gene is associated with coronary artery disease in Chinese Han population

Shuo Pan, Gong-Chang Guan, Ying Lv, Zhong-Wei Liu, Fu-Qiang Liu, Yong Zhang, Shun-Ming Zhu, Rong-Huai Zhang, Na Zhao, Shuang Shi, Tomohiro Nakayama and Jun-Kui Wang _

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Oncotarget. 2017; 8:82165-82173. https://doi.org/10.18632/oncotarget.19280

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Abstract

Shuo Pan1,*, Gong-Chang Guan1,*, Ying Lv1,*, Zhong-Wei Liu1, Fu-Qiang Liu1, Yong Zhang1, Shun-Ming Zhu1, Rong-Huai Zhang1, Na Zhao1, Shuang Shi1, Tomohiro Nakayama2 and Jun-Kui Wang1

1First Department of Cardiology, People’s Hospital of Shaanxi Province, Xi’an, People’s Republic of China

2Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan

*These authors have contributed equally to this work

Correspondence to:

Jun-Kui Wang, email: [email protected]

Keywords: coronary artery disease, GOSR2, single nucleotide polymorphism, haplotype, genetic

Received: March 06, 2017 Accepted: June 18, 2017 Published: July 17, 2017

ABSTRACT

Objectives: The aim of the present study is to assess the association between the human GOSR2 gene and coronary artery disease using a haplotype-based case-control study in Chinese Han population.

Methods: A total of 283 coronary artery disease patients and 280 controls were genotyped for the human GOSR2 gene (rs197932, rs3785889, rs197922, rs17608766, and rs16941382). Data were analyzed for three separate groups: the total subjects, men, and women.

Results: For the total subjects, the frequency of the G-T haplotype established by rs3785889-rs16941382 was significantly higher in the coronary artery disease patients as compared to the control subjects (P=0.009). Multiple logistic regression analysis also confirmed that the subjects with G-T haplotype established by rs3785889-rs16941382 (homozygote) were found having significantly higher chance suffering from coronary artery disease than the ones without this haplotype (OR=1.887, P=0.007).

Conclusions: The G-T haplotype established by rs3785889-rs16941382 may be a risk genetic marker for coronary artery disease patients in Chinese Han population.

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Research Papers:

G-T haplotype established by rs3785889-rs16941382 in GOSR2 gene is associated with coronary artery disease in Chinese Han population

Abstract