The lifecycle of the Ebola virus in host cells

Dong-Shan Yu; Tian-Hao Weng; Xiao-Xin Wu; Frederick X.C. Wang; Xiang-Yun Lu; Hai-Bo Wu; Nan-Ping Wu; Lan-Juan Li; Hang-Ping Yao

doi:10.18632/oncotarget.18498

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The lifecycle of the Ebola virus in host cells

Dong-Shan Yu, Tian-Hao Weng, Xiao-Xin Wu, Frederick X.C. Wang, Xiang-Yun Lu, Hai-Bo Wu, Nan-Ping Wu, Lan-Juan Li and Hang-Ping Yao _

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Oncotarget. 2017; 8:55750-55759. https://doi.org/10.18632/oncotarget.18498

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Abstract

Dong-Shan Yu1,2,*, Tian-Hao Weng1,2,*, Xiao-Xin Wu1,2, Frederick X.C. Wang3, Xiang-Yun Lu1,2, Hai-Bo Wu1,2, Nan-Ping Wu1,2, Lan-Juan Li1,2 and Hang-Ping Yao1,2

1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China

3Department of Bioengineering, Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Dallas, TX, USA

*These authors contributed equally to this work

Correspondence to:

Hang-Ping Yao, email: [email protected]

Lan-Juan Li, email: [email protected]

Keywords: Ebola virus, EBOV proteins, EBOV lifecycle

Received: April 21, 2017 Accepted: May 29, 2017 Published: June 15, 2017

ABSTRACT

Ebola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle. Furthermore, the review outlines the aspects remain unclear that urgently need to be solved in future research.

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The lifecycle of the Ebola virus in host cells

Abstract