Protein salvador homolog 1 acts as a tumor suppressor and is modulated by hypermethylation in pancreatic ductal adenocarcinoma

Lei Wang; Mei Wang; Chenxi Hu; Pengping Li; Yun Qiao; Youyou Xia; Liang Liu; Xiaodong Jiang

doi:10.18632/oncotarget.17972

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Research Papers:

Protein salvador homolog 1 acts as a tumor suppressor and is modulated by hypermethylation in pancreatic ductal adenocarcinoma

Lei Wang, Mei Wang, Chenxi Hu, Pengping Li, Yun Qiao, Youyou Xia, Liang Liu and Xiaodong Jiang _

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Oncotarget. 2017; 8:62953-62961. https://doi.org/10.18632/oncotarget.17972

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Abstract

Lei Wang1,*, Mei Wang2,*, Chenxi Hu2,*, Pengping Li3, Yun Qiao1, Youyou Xia1, Liang Liu1 and Xiaodong Jiang4

1Department of Radiation Oncology, Lianyungang First People’s Hospital, Jiangsu, People’s Republic of China

2Tumor Laboratory, Department of Radiation Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Jiangsu, People’s Republic of China

3Department of Bioinformatics, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, People’s Republic of China

4Department of Radiation Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Jiangsu, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Xiaodong Jiang, email: [email protected]

Keywords: SAV1, tumor suppressor, pancreatic ductal adenocarcinoma, hypermethylation

Received: January 13, 2017 Accepted: April 11, 2017 Published: May 18, 2017

ABSTRACT

Salvador (SAV) is a gene product that contains two protein-protein interaction modules known as WW domains and is believed to act as a scaffolding protein for Hippo and Warts. SAV1 is the human homolog of Salvador, which is the most well characterized upstream signaling component of Hippo pathway. Although its role in some tumors is known, SAV1 function in other types of tumors, including pancreatic tumor, is still obscure. Here, we determined the role of SAV1 in pancreatic ductal adenocarcinoma (PDAC) development and progression. Our results revealed that SAV1 suppressed expression promoted PDAC invasion and migration, and repressed pancreatic cancer cells apoptosis. Moreover, SAV1 was silenced by hypermethylation. Thus, SAV1 worked as a cancer suppressor and it might be considered as a target for pancreatic cancer therapy.

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Research Papers:

Protein salvador homolog 1 acts as a tumor suppressor and is modulated by hypermethylation in pancreatic ductal adenocarcinoma

Abstract