18 F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma

Ping Huang; Xiang Zhao; Weiyuan Xiao; Yuqi Dong; Guangyu Hu

doi:10.18632/oncotarget.17377

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Research Papers:

¹⁸F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma

Ping Huang, Xiang Zhao, Weiyuan Xiao, Yuqi Dong and Guangyu Hu _

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Oncotarget. 2017; 8:39618-39626. https://doi.org/10.18632/oncotarget.17377

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Abstract

Ping Huang1,*, Xiang Zhao1,*, Weiyuan Xiao1, Yuqi Dong1 and Guangyu Hu1

1Department of Orthopaedics, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Guangyu Hu, email: [email protected]

Yuqi Dong, email: [email protected]

Keywords: lung adenocarcinomas, PKM2, glycolysis, ¹⁸F-FDG uptake

Received: November 01, 2016 Accepted: March 29, 2017 Published: April 24, 2017

ABSTRACT

Positron emission tomography (PET) with ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) is widely used in the management of lung adenocarcinoma. Pyruvate kinase M2 (PKM2) plays a key role in glycolysis. We therefore investigated whether PKM2 expression affects ¹⁸F-FDG uptake in a retrospective analysis of 76 patients who underwent ¹⁸F-FDG PET/computed tomography (CT) scans for staging before surgical resection. We found that PKM2 expression was higher in tumors than peritumoral tissue (p < 0.05). Patients with high PKM2 expression had reduced overall (p < 0.05) and disease-free (p < 0.05) survival as compared to those with low PKM2 expression. Comparison of the primary tumor maximum standardized uptake value (SUVmax) between patients with high and low PKM2 expression revealed that the SUVmax was higher in primary tumors with high PKM2 expression than low PKM2 expression (p < 0.05). Multivariate analysis confirmed the association between SUVmax and PKM2 expression (p < 0.05). PKM2 status was predicted with 81.6% accuracy when the SUVmax cutoff value of 6.4. Thus,¹⁸F-FDG PET/CT is predictive of the PKM2 status in lung adenocarcinoma patients and could aid in determining therapeutic strategies.

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Research Papers:

18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma

Abstract

¹⁸F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma