Non-coding RNAs as emerging regulators of epithelial to mesenchymal transition in non-small cell lung cancer

Ying Chen; Lu Lu; Bing Feng; Siqi Han; Shiyun Cui; Xiaoyuan Chu; Longbang Chen; Rui Wang

doi:10.18632/oncotarget.16375

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Non-coding RNAs as emerging regulators of epithelial to mesenchymal transition in non-small cell lung cancer

Ying Chen, Lu Lu, Bing Feng, Siqi Han, Shiyun Cui, Xiaoyuan Chu, Longbang Chen and Rui Wang _

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Oncotarget. 2017; 8:36787-36799. https://doi.org/10.18632/oncotarget.16375

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Abstract

Ying Chen1, Lu Lu1, Bing Feng1, Siqi Han1, Shiyun Cui1, Xiaoyuan Chu1, Longbang Chen1 and Rui Wang1

1 Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, PR China

Correspondence to:

Rui Wang, email:

Keywords: non-coding RNA; non-small cell lung cancer; microRNA; long-coding RNA; epithelial-mesenchymal transition

Received: December 14, 2016 Accepted: February 28, 2017 Published: March 18, 2017

Abstract

Non-small cell lung cancer (NSCLC) remains a major health problem that patients suffer from around the world. The epithelial to mesenchymal transition (EMT) has attractive roles in increasing malignant potential and reducing sensitivity to conventional therapeutics in NSCLC cells. Meanwhile, it is now evident that non-coding RNAs (ncRNAs), primarily microRNAs and long non-coding RNAs contribute to tumorigenesis partially via regulating EMT. This article briefly summarizes current researches about EMT-related ncRNAs in NSCLC and discusses their crucial roles in the complex regulatory network. Also, the authors will show the evidence that ncRNAs not only contribute to cancer cells migration and invasion, but also take charge of the resistance of chemotherapy, radiotherapy and EGFR-TIKs. Then, we will further discuss the potential of inhibition of EMT via manipulating relevant ncRNAs to change our current treatment of NSCLC patients.

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Non-coding RNAs as emerging regulators of epithelial to mesenchymal transition in non-small cell lung cancer

Abstract