Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients

Jiayi Wu; Yan Fang; Lin Lin; Xiaochun Fei; Weiqi Gao; Siji Zhu; Yu Zong; Xiaosong Chen; Ou Huang; Jian-Rong He; Li Zhu; Weiguo Chen; Yafen Li; Kunwei Shen

doi:10.18632/oncotarget.16313

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Research Papers:

Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients

Jiayi Wu, Yan Fang, Lin Lin, Xiaochun Fei, Weiqi Gao, Siji Zhu, Yu Zong, Xiaosong Chen, Ou Huang, Jian-Rong He, Li Zhu, Weiguo Chen, Yafen Li and Kunwei Shen _

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Abstract

Jiayi Wu1, Yan Fang1, Lin Lin2, Xiaochun Fei3, Weiqi Gao1, Siji Zhu1, Yu Zong1, Xiaosong Chen1, Ou Huang1, Jian-Rong He1, Li Zhu1, Weiguo Chen1, Yafen Li1 and Kunwei Shen1

1Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

2Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

3Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

Correspondence to:

Kunwei Shen, email: [email protected]

Keywords: breast carcinoma, 21-gene, risk score, clinico-pathologic factors

Received: August 31, 2016 Accepted: January 16, 2017 Published: March 17, 2017

ABSTRACT

Aim: The current study aimed to explore the distribution patterns of 21-gene recurrence score (RS) assay in Chinese early breast cancer patients.

Methods: Nine hundred and eighty consecutive estrogen receptor(ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer patients treated at Ruijin Hospital, Shanghai Jiaotong University, School of Medicine from 2009 to 2016 were retrospectively recruited. Reverse transcriptase-polymerase chain reaction (RT-PCR) assay of 21 genes were conducted in paraffin-embedded tumor tissue to calculate the RS. Co-relations of RS and clinico-pathologic factors were evaluated. Concordances of RT-PCR and immunohistochemistry (IHC) tests were measured. Logistic regression were applied to determine independent variables associated with RS.

Results: The median RS of 980 patients was 23(0~90), and the proportions of patients categorized as having a low, intermediate, or high risk were 26.1%, 49.3% and 24.6%. The distribution of RS varied significantly according to different tumor grade, T stage, progesterone receptor(PR) status, Ki67 index and molecular subtypes (p<0.05). Grade, PR status and Ki67 index were identified as independent variables associated with RS. The concordance rates between RT-PCR and IHC test were 98.8% and 88.3% for ER and PR status, and there were weak to moderate correlation between IHC and RT-PCR tests for ER, PR expression and Ki67 index.

Conclusions: RS correlated significantly with grade, T stage, PR status, Ki67 index and molecular subtypes in Chinese early breast cancer patients. Grade, PR status and Ki67 index could independently predict RS. ER, PR status and Ki67 index between RT-PCR and IHC test had remarkable concordance.

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Research Papers:

Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients

Abstract