Transport stress induces weight loss and heart injury in chicks: disruption of ionic homeostasis via modulating ion transporting ATPases

Zhao-Yang Li; Jia Lin; Feng Sun; Hui Li; Jun Xia; Xue-Nan Li; Jing Ge; Cong Zhang; Jin-Long Li

doi:10.18632/oncotarget.15903

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Research Papers: Pathology:

Transport stress induces weight loss and heart injury in chicks: disruption of ionic homeostasis via modulating ion transporting ATPases

Zhao-Yang Li, Jia Lin, Feng Sun, Hui Li, Jun Xia, Xue-Nan Li, Jing Ge, Cong Zhang and Jin-Long Li _

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Oncotarget. 2017; 8:24142-24153. https://doi.org/10.18632/oncotarget.15903

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Abstract

Zhao-Yang Li1,*, Jia Lin1,*, Feng Sun1,*, Hui Li1,2,*, Jun Xia1,3, Xue-Nan Li1,4, Jing Ge1,4, Cong Zhang1,3 and Jin-Long Li1,3,4

1 College of Veterinary Medicine, Northeast Agricultural University, Harbin, P. R. China

2 Harbin Sport University, Harbin, P. R. China

3 Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Key Laboratory of the Provincial Education Northeast Agricultural University, Harbin, P. R. China

4 Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, P. R. China

* These authors have contributed equally to this work

Correspondence to:

Jin-Long Li, email:

Keywords: transport stress; weight loss; heart injury; ionic disorder; ATPase; Pathology Section

Received: January 13, 2017 Accepted: February 24, 2017 Published: March 04, 2017

Abstract

Transportation is inevitable in the poultry industry, and it can induce stress to chicks in varying degrees, such as mild discomfort, sometimes even death. However, the research about the effects of transport stress on the weight loss and heart injury of chicks is lacking. To elucidate the underlying mechanism of transport stress-induced effects, chicks were transported for 2h, 4h and 8h. The creatinine kinase (CK) activities, the ionic contents, the ATPases activities and the transcription of the ATPase associated subunits in chick heart were detected. The results showed that transport stress increased the weight loss and the CK activity, disturbed the ionic (K+, Ca2+, Mg2+) homeostasis and inhibited the ATPase (Na+-K+-ATPase, Ca2+-ATPase, Mg2+-ATPase and Ca2+-Mg2+-ATPase) activities, increased the ATP content and downregulated the gene expression levels of the ATPase associated subunits in heart. In conclusion, transport stress disturbed the ionic homeostasis via modulating ion transporting ATPases and the transcriptions of the associated subunits, and ultimately induced weight loss and heart injury in chicks.

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Research Papers: Pathology:

Transport stress induces weight loss and heart injury in chicks: disruption of ionic homeostasis via modulating ion transporting ATPases

Abstract