The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy

Xiaojing Yang; Hanru Ren; Yi Sun; Lihua Zhang; Xinmiao Yang; Hongling Li; Yuhui Shao; Jie Fu

doi:10.18632/oncotarget.15805

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Research Papers:

The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy

Xiaojing Yang _, Hanru Ren, Yi Sun, Lihua Zhang, Xinmiao Yang, Hongling Li, Yuhui Shao and Jie Fu

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Oncotarget. 2017; 8:25279-25288. https://doi.org/10.18632/oncotarget.15805

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Abstract

Xiaojing Yang1,*, Hanru Ren2,*, Yi Sun1, Lihua Zhang1, Xinmiao Yang1, Hongling Li1, Yuhui Shao1, Jie Fu1

1Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

2Department of Orthopaedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Xiaojing Yang, email: [email protected]

Keywords: D-dimer, endometrial cancer, prognosis, intensity-modulated radiation therapy

Received: November 04, 2016 Accepted: February 08, 2017 Published: February 28, 2017

ABSTRACT

Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for endometrial cancer. The D-dimer levels of forty patients with endometrial cancer were assessed before (D1) and after (D2) intensity-modulated radiation therapy (IMRT), respectively. The D-dimer level changes (ΔD) were defined as D2 minus D1. Cox regression and log-rank tests were used to evaluate the D-dimer levels in relation to progression free survival (PFS) and overall survival (OS). The OS and PFS of patients with a low D1 were significantly longer than those with a high D1 (P< 0.001, P< 0.001). We saw the similar correlation between D2, PFS and OS (P< 0.001, P< 0.001). Multivariate survival analyses showed that D-dimer was independently associated with OS and PFS in patients with endometrial cancer. The ΔD level was not related to the OS and PFS in endometrial cancer patients. The levels of D-dimer may be considered as an important predictor of PFS and OS in endometrial cancer patients treated with IMRT.

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Research Papers:

The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy

Abstract