Genetic characterization and antiretroviral resistance mutations among treatment-naive HIV-infected individuals in Jiaxing, China

Jinlei Guo; Yong Yan; Jiafeng Zhang; Jimei Ji; Zhijian Ge; Rui Ge; Xiaofei Zhang; Henghui Wang; Zhongwen Chen; Jianyong Luo

doi:10.18632/oncotarget.15382

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Research Papers:

Genetic characterization and antiretroviral resistance mutations among treatment-naive HIV-infected individuals in Jiaxing, China

Jinlei Guo, Yong Yan, Jiafeng Zhang, Jimei Ji, Zhijian Ge, Rui Ge, Xiaofei Zhang, Henghui Wang, Zhongwen Chen and Jianyong Luo _

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Oncotarget. 2017; 8:18271-18279. https://doi.org/10.18632/oncotarget.15382

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Abstract

Jinlei Guo1,*, Yong Yan1,*, Jiafeng Zhang2,*, Jimei Ji1, Zhijian Ge1, Rui Ge1, Xiaofei Zhang1, Henghui Wang1, Zhongwen Chen1, Jianyong Luo1

1Jiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Municipal Center for Disease Control and Prevention, Jiaxing 314001, PR China

2Institute of AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, PR China

*These authors have contributed equally in this study

Correspondence to:

Jianyong Luo, email: [email protected]

Keywords: HIV-1, treatment-naive, genotype, drug resistance, genetic diversity

Received: November 20, 2016 Accepted: January 11, 2017 Published: February 16, 2017

ABSTRACT

The aim of this study was to characterize HIV-1 genotypes and antiretroviral resistance mutations among treatment-naive HIV-infected individuals in Jiaxing, China. The HIV-1 partial polymerase (pol) genes in 93 of the 99 plasma samples were successfully amplified and analyzed. Phylogenetic analysis revealed the existence of five HIV-1 genotypes, of which the most prevalent genotype was CRF01_AE (38.7%), followed by CRF07_BC (34.4%), CRF08_BC (16.1%), subtype B/B’ (5.4%), and CRF55_01B (2.1%). Besides, three types of unique recombination forms (URFs) were also observed, including C/F2/A1, CRF01_AE/B, and CRF08_BC/CRF07_BC. Among 93 amplicons, 46.2% had drug resistance-associated mutations, including 23.7% for protease inhibitors (PIs) mutations, 1.1% for nucleoside reverse transcriptase inhibitors (NRTIs) mutations, and 20.4% for non-nucleoside reverse transcriptase inhibitors (NNRTIs) mutations. Six (6.5%) out of 93 treatment-naive subjects were identified to be resistant to one or more NNRTIs, while resistance to NRTIs or PIs was not observed. Our study showed the genetic diversity of HIV-1 strains circulating in Jiaxing and a relative high proportion of antiretroviral resistance mutations among treatment-naive patients, indicating a serious challenge for HIV prevention and treatment program.

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Research Papers:

Genetic characterization and antiretroviral resistance mutations among treatment-naive HIV-infected individuals in Jiaxing, China

Abstract