S100A7 promotes the migration, invasion and metastasis of human cervical cancer cells through epithelial–mesenchymal transition

Tian Tian; Xukun Li; Zhen Hua; Jianlin Ma; Xiaowei Wu; Zhihua Liu; Hongyan Chen; Zhumei Cui

doi:10.18632/oncotarget.15329

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Research Papers:

S100A7 promotes the migration, invasion and metastasis of human cervical cancer cells through epithelial–mesenchymal transition

Tian Tian, Xukun Li, Zhen Hua, Jianlin Ma, Xiaowei Wu, Zhihua Liu, Hongyan Chen _ and Zhumei Cui

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Oncotarget. 2017; 8:24964-24977. https://doi.org/10.18632/oncotarget.15329

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Abstract

Tian Tian1,*, Xukun Li2,*, Zhen Hua3,*, Jianlin Ma2, Xiaowei Wu2, Zhihua Liu2, Hongyan Chen2, Zhumei Cui1

1Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266061, People’s Republic of China

2State Key Lab of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People’s Republic of China

3Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao 266061, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Hongyan Chen, email: [email protected]

Zhumei Cui, email: [email protected]

Keywords: S100A7, cervical cancer, invasion, metastasis, EMT

Received: June 09, 2016 Accepted: January 23, 2017 Published: February 15, 2017

ABSTRACT

S100A7 is an EF-hand calcium-binding protein that has been suggested to be implicated in cell proliferation, migration, invasion and tumor metastasis. However, its role in cervical cancer has not yet been fully clarified. The present study used immunohistochemistry analysis of S100A7 in clinical specimens of cervical cancer to show that S100A7 expression was significantly upregulated in cervical cancer tissues compared with normal cervical tissues and S100A7 expression in high grade cervical intraepithelial neoplasm (CIN) was significantly higher than cervical cancer. Statistical analysis showed that S100A7 expression was associated with tumor grade (P <0.01) and lymph node metastasis (P <0.05). Functional studies showed that overexpression of S100A7 in cervical cancer cells promoted migration, invasion and metastasis of cervical cancer cells without influencing cell proliferation. Furthermore, S100A7 was found to be secreted into the conditioned media and extracellular S100A7 enhanced cell migration and invasion. Mechanistically, S100A7 bound to RAGE and activated ERK signaling pathway. And S100A7 enhanced cell mesenchymal properties and induced epithelial–mesenchymal transition. In summary, these data reveal a crucial role for S100A7 in regulating cell migration, invasion, metastasis and EMT of cervical cancer and suggest that targeting S100A7 may offer a new targeted strategy for cervical cancer.

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Research Papers:

S100A7 promotes the migration, invasion and metastasis of human cervical cancer cells through epithelial–mesenchymal transition

Abstract