Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

Wenhong Zhou; Junfeng Zhao; Xiaohua Pan; Yongjie Sun; Hao Xu; Peng Shi; Chong Geng; Ling Gao; Xingsong Tian

doi:10.18632/oncotarget.14598

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This article has been retracted. Retraction in: Oncotarget. 2023; 14:943-943.

Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

Wenhong Zhou _, Junfeng Zhao, Xiaohua Pan, Yongjie Sun, Hao Xu, Peng Shi, Chong Geng, Ling Gao and Xingsong Tian

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Oncotarget. 2017; 8:11621-11628. https://doi.org/10.18632/oncotarget.14598

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Abstract

Guojun Wu1,*, Wenhong Zhou2,*, Junfeng Zhao3, Xiaohua Pan1, Yongjie Sun1, Hao Xu1, Peng Shi1, Chong Geng1, Ling Gao4, Xingsong Tian1

1Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China

2Department of Nursing, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China

3Traffic Police Department, Jinan Public Security Bureau, Jinan 250021, Shandong, P. R. China

4Scientific Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China

*These authors contributed equally to this work

Correspondence to:

Ling Gao, email: [email protected]

Xingsong Tian, email: [email protected]

Keywords: matrine, inflammation, oxidative stress, CCR7, LPS

Received: December 10, 2016 Accepted: December 27, 2016 Published: January 11, 2017

ABSTRACT

The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal.

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Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

Abstract