Targeting microRNAs: a new action mechanism of natural compounds

Qian Lin; Leina Ma; Zhantao Liu; Zhihong Yang; Jin Wang; Jia Liu; Guohui Jiang

doi:10.18632/oncotarget.14392

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Targeting microRNAs: a new action mechanism of natural compounds

Qian Lin, Leina Ma, Zhantao Liu, Zhihong Yang, Jin Wang, Jia Liu _ and Guohui Jiang

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Oncotarget. 2017; 8:15961-15970. https://doi.org/10.18632/oncotarget.14392

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Abstract

Qian Lin1, Leina Ma2, Zhantao Liu1, Zhihong Yang1, Jin Wang1, Jia Liu1 and Guohui Jiang1

1 College of Medicine, Qingdao University, Qingdao, China

2 The Department of Oncology, The First Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China

Correspondence to:

Jia Liu, email:

Guohui Jiang, email:

Keywords: natural compounds; miRNAs; cancer

Received: September 20, 2016 Accepted: December 01, 2016 Published: December 30, 2016

Abstract

Unlike genetics, epigenetics involves the modification of genome without changes in DNA sequences, including DNA methylation, histone modification, chromatin remodeling and noncoding RNA regulation. MicroRNA (miRNA), a member of noncoding RNAs superfamily, participates in RNA interference through a unique mechanism. Currently, microRNAs have been found to be regulated by some natural compounds. Through altering the expression of miRNAs and influencing the downstream signaling pathways or target genes, several natural compounds exhibit its bioactivity in the prevention, diagnosis, therapy, prognosis and drug resistance of human diseases, such as cancer. In this review, several natural compounds and their studies about miRNA-related action mechanism were summarized. These studies provide a new insight into action mechanism by which natural compound exerts its bioactivity and a novel treatment strategy, demonstrating natural compound a promising remedy for clinical treatments.

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Targeting microRNAs: a new action mechanism of natural compounds

Abstract