What influences preneoplastic colorectal lesion recurrence?

Giulia De Maio; Elisa Zama; Claudia Rengucci; Daniele Calistri

doi:10.18632/oncotarget.13628

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

What influences preneoplastic colorectal lesion recurrence?

Giulia De Maio _, Elisa Zama, Claudia Rengucci and Daniele Calistri

PDF | HTML | How to cite

Oncotarget. 2017; 8:12406-12416. https://doi.org/10.18632/oncotarget.13628

Metrics: PDF 2176 views | HTML 1868 views | ?

Abstract

Giulia De Maio1, Elisa Zama1, Claudia Rengucci1, Daniele Calistri1

1Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC), Italy

Correspondence to:

Daniele Calistri, email: [email protected]

Keywords: recurrence, preneoplastic lesions, suppressor and serrated pathway, microbiota

Received: August 02, 2016 Accepted: November 15, 2016 Published: November 25, 2016

ABSTRACT

The hypothesis of the local recurrence of preneoplastic lesions was first put forward in the 1950s. Disease recurrence may result from an inherent imbalance in cell proliferation that promotes carcinogenesis in apparently normal mucosa. Our review sheds light on how early preneoplastic lesions could be used to diagnose relapsed preneoplastic and, developing neoplastic lesions. We focus in detail on the clinical-pathological and molecular features of adenoma subtypes and their role in relapsed adenoma and their development into colorectal carcinoma. Moreover, we include the data available on microbiota and its metabolites and their role in recurrence. We strongly believe that a significant improvement could be achieved in colorectal screening by introducing personalized endoscopic surveillance for polyp-bearing patients on the basis of the presence of molecular markers that are predictive of recurrence.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13628

Publication Alerts

Reviews:

What influences preneoplastic colorectal lesion recurrence?

Abstract